A5080358278- Optimization and Packing Problems
- Metaheuristic Optimization Algorithms Research
- Genetics and Neurodevelopmental Disorders
- Vehicle Routing Optimization Methods
- Optimization and Search Problems
- Alzheimer's disease research and treatments
- Pharmacological Receptor Mechanisms and Effects
- Neuroinflammation and Neurodegeneration Mechanisms
- Smart Agriculture and AI
- Horticultural and Viticultural Research
- Advanced Manufacturing and Logistics Optimization
- Insect behavior and control techniques
- Biochemical effects in animals
- Greenhouse Technology and Climate Control
- Protein Degradation and Inhibitors
- Quantum-Dot Cellular Automata
- Neurological Disorders and Treatments
- Occupational Health and Safety Research
- Epilepsy research and treatment
- Infrastructure Maintenance and Monitoring
- Plant Gene Expression Analysis
- Bioinformatics and Genomic Networks
- Gut microbiota and health
- Advanced Bandit Algorithms Research
- Ubiquitin and proteasome pathways
University of the Americas
2020-2024
Pontificia Universidad Católica de Valparaíso
2019-2024
Inria Chile
2024
Adolfo Ibáñez University
2017-2018
Dirección de Investigación y Desarrollo
2017-2018
Production Development Corporation
2017
Fraunhofer Chile Research Foundation
2015-2017
University of Chile
2015
Early detection of Lobesia botrana is a primary issue for proper control this insect considered as the major pest in grapevine. In article, we propose novel method L. recognition using image data mining based on clustering segmentation with descriptors which consider gray scale values and gradient each segment. This system allows 95 percent non-fully controlled lighting, zoom, orientation environments. Our capture application currently implemented mobile subsequent processing done cloud.
The progress of metaheuristic techniques, big data, and the Internet things generates opportunities to performance improvements in complex industrial systems. This article explores application Big Data techniques implementation algorithms with purpose applying it decision‐making processes. exploration intends evaluate quality results convergence times algorithm under different conditions number solutions processing capacity. Under what can we obtain acceptable an adequate iterations? In this...
The integration of machine learning techniques and metaheuristic algorithms is an area interest due to the great potential for applications. In particular, using these hybrid solve combinatorial optimization problems (COPs) improve quality solutions convergence times in operations research. this article, db-scan unsupervised technique explored with goal it binarization process continuous swarm intelligence algorithms. contribution operator analyzed systematically through design random...
La producción intensiva de cerdos es un sistema para criar grandes cantidades animales en instalaciones cerradas y controladas maximizar el rendimiento reducir los costos. Sin embargo, este enfoque ha sido criticado debido a preocupaciones sobre bienestar animal, la sostenibilidad ambiental uso excesivo antibióticos. Considerando relevancia último punto, presente revisión tuvo como objetivo evaluar evidencia disponible presencia genes resistencia compuestos antimicrobianos cultivos...
The human gut microbiome is the ecosystem of microorganisms that live in digestive system. Several studies have related variants to metabolic, immune and nervous system disorders. Fragile X syndrome (FXS) a neurodevelopmental disorder considered most common cause inherited intellectual disability leading monogenetic autism. role FXS remains largely unexplored. Here, we report results analysis using mouse model 16S ribosomal RNA gene sequencing. We identified alterations fmr1 KO2 associated...
Alzheimer's disease (AD) is the most common cause of dementia, affecting more than 36 million people worldwide. Octodon degus, a South American rodent, has been found to spontaneously develop neuropathological signs AD, including amyloid-β (Aβ) and tau deposits, as well decline in cognition with age. Firstly, present work introduces novel behavioral assessment for O. degus - burrowing test which appears be useful tool detecting neurodegeneration model AD. Such characterization potentially...
Fragile X syndrome (FXS), a disorder of synaptic development and function, is the most prevalent genetic form intellectual disability autism spectrum disorder. FXS mouse models display clinically-relevant phenotypes, such as increased anxiety hyperactivity. Despite their availability, so far advances in drug have not yielded new treatments. Therefore, testing novel drugs that can ameliorate FXS' cognitive behavioral impairments imperative. ANAVEX2-73 (blarcamesine) sigma-1 receptor (S1R)...
Optimization techniques, specially metaheuristics, are constantly refined in order to decrease execution times, increase the quality of solutions, and address larger target cases. Hybridizing techniques one these strategies that particularly noteworthy due breadth applications. In this article, a hybrid algorithm is proposed integrates k-means generate binary version cuckoo search technique, strengthened by local operator. The applied NP-hard Set-Union Knapsack Problem. This problem has...
Abstract Fragile X syndrome (FXS), an X-chromosome linked intellectual disability, is the leading monogenetic cause of autism spectrum disorder (ASD), a neurodevelopmental condition that currently has no specific drug treatment. Building upon demonstrated therapeutic effects on spatial memory bryostatin-1, relatively activator protein kinase C (PKC)ε, (also PKCα) impaired synaptic plasticity/maturation and learning in FXS mice, we investigated whether bryostatin-1 might affect autistic...
In agricultural production, it is fundamental to characterize the phenological stage of plants ensure a good evaluation development, growth and health crops. Phenological characterization allows for early detection nutritional deficiencies in that diminish productive yield drastically affect quality their fruits. Currently, estimation development grapevine (Vitis vinifera) carried out using four different schemes: Baillod Baggiolini, Extended BBCH, Eichhorn Lorenz, Modified E-L. requires...
DATA REPORT article Front. Aging Neurosci., 20 March 2017Sec. Alzheimer's Disease and Related Dementias Volume 9 - 2017 | https://doi.org/10.3389/fnagi.2017.00064
The degu ( Octodon degus ) is a diurnal long-lived rodent that can spontaneously develop molecular and behavioral changes mirror those seen in human aging. With age some degu, but not all individuals, cognitive decline brain pathology like observed Alzheimer's disease including neuroinflammation, hyperphosphorylated tau amyloid plaques, together with other co-morbidities associated aging such as macular degeneration, cataracts, alterations circadian rhythm, diabetes atherosclerosis. Here we...
Retraction : “Nrf2: a novel therapeutic target in fragile X syndrome is modulated by NNZ2566” R. M. J. Deacon, Hurley, C. Rebolledo, Snape, F. Altimiras, L. Farías, Pino, Biekofsky, Glass and P. Cogram. The above article, from Genes, Brain Behavior, published online on 12th May 2017 Wiley Online Library ( wileyonlinelibrary.com ), has been retracted agreement between the journal Editor Chief, Andrew Holmes John & Sons Ltd. retraction agreed as all authors cannot agree revised author...
The binarization mechanisms of continuous metaheuristics are interest in operational research. This is mainly due to the fact that there a lot combinatorial problems NP-hard. In this article, we exploit concept percentile as mechanism swarm intelligence metaheuristics. To evaluate behavior our binary operator, Multi-verse metaheuristic used and applied solve problem knapsack. algorithm obtained, multi-verse Optimizer (BMVO) shows good performance solving most difficult
Abstract Fragile X syndrome (FXS), a disorder of synaptic development and function, is the most prevalent genetic form intellectual disability autism spectrum disorder. FXS mouse models display clinically-relevant phenotypes, such as increased anxiety hyperactivity. Despite their availability, so far advances in drug have not yielded new treatments. Therefore, testing novel drugs that can ameliorate FXS’ cognitive behavioral impairments imperative. ANAVEX2-73 (blarcamesine) sigma-1 receptor...