A5018196704- CRISPR and Genetic Engineering
- Genomics and Chromatin Dynamics
- Chromosomal and Genetic Variations
- RNA Research and Splicing
- International Relations and Foreign Policy
- RNA and protein synthesis mechanisms
- Advanced biosensing and bioanalysis techniques
- Economic Sanctions and International Relations
- Pluripotent Stem Cells Research
- Nuclear Issues and Defense
- Developmental Biology and Gene Regulation
- Renal and related cancers
Max Planck Institute of Immunobiology and Epigenetics
2020-2024
University of Freiburg
2020-2024
The NSL complex is a transcriptional activator. Germline-specific knockdown of subunits NSL1, NSL2, and NSL3 results in reduced piRNA production from subset bidirectional clusters, accompanied by widespread transposon derepression. piRNAs most transcriptionally affected NSL2 NSL1 RNAi map to telomeric clusters. At the chromatin level, these clusters also show decreased levels H3K9me3, HP1a, Rhino after depletion. Using ChIP-seq ovaries, we found that this protein specifically binds promoters...
ABSTRACTFor the first time since end of Cold War, heightened risks a nuclear catastrophe are being seriously felt around world. Over past decade, Nuclear Non-Proliferation Treaty (NPT) – central instrument global non-proliferation regime has been rife with divisions among its members and undermined by failure two consecutive Review Conferences (RevCons) to adopt consensus outcome document. The basic assertion underlying this Special Issue is that there growing criticism or contestation from...