A5069815731- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Travel-related health issues
- Liver Diseases and Immunity
- Systemic Lupus Erythematosus Research
- Hepatitis Viruses Studies and Epidemiology
- Liver Disease and Transplantation
- Antibiotic Resistance in Bacteria
- Antimicrobial agents and applications
- Monoclonal and Polyclonal Antibodies Research
- Escherichia coli research studies
- Viral gastroenteritis research and epidemiology
- Salmonella and Campylobacter epidemiology
- Pneumocystis jirovecii pneumonia detection and treatment
- Heparin-Induced Thrombocytopenia and Thrombosis
- Diabetes and associated disorders
- MicroRNA in disease regulation
- Renal Transplantation Outcomes and Treatments
- HIV Research and Treatment
- Antimicrobial Peptides and Activities
- Organ Transplantation Techniques and Outcomes
- Global Health Workforce Issues
- Barrier Structure and Function Studies
- Neurological Disease Mechanisms and Treatments
Universitat de Barcelona
2007-2018
Barcelona Institute for Global Health
2018
Hospital Clínic de Barcelona
2010-2015
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2010-2014
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2010-2014
Barcelona Centre for International Affairs
2013
University Health Network
2013
Kyushu University
2013
Centre de Recerca en Economia Internacional
2008-2011
Georgetown University Medical Center
2011
The antimicrobial susceptibility and mechanisms of resistance 109 Shigella 40 Salmonella isolates from children with diarrhea in southern Mozambique were assessed. to seven agents was tested by disk diffusion, searched PCR or colorimetric method. A high proportion resistant chloramphenicol (Chl) (52%), ampicillin (Amp) (56%), tetracycline (Tet) (66%), trimethoprim-sulfamethoxazole (Sxt) (84%). Sixty-five percent the multidrug resistant. flexneri more than those sonnei Amp (66% versus 0.0%, P...
Liver transplantation (LT) of hepatitis C virus (HCV)-infected grafts into HCV-infected recipients leads to superinfection with two different strains. To characterize the virological outcomes HCV immediately after LT, we performed phylogenetic analysis a fragment NS5B gene in donor and recipient serum samples prospectively collected before starting on day 1. In four six cases, strain finally prevailed, while remaining native overtook quasispecies. Clonal sequence showed that, three expelled...
Abstract Liver transplantation (LT) is a unique model to study hepatitis C virus (HCV) entry into hepatocytes. Recent in vitro studies suggest significant changes the expression of HCV receptors claudin-1 and occludin after infection. Our aims were: (1) characterize grafts from LT recipients (2) explore their potential influence on early kinetics We included 42 HCV-infected 19 uninfected controls. Claudin-1 were detected paraffin-embedded liver biopsies obtained during reperfusion 3 12...
To select rifaximin-resistant mutants of Escherichia coli and to establish the frequency mutation, cross-resistance with other antimicrobial agents stability obtained. Four E. isolates [two enteroaggregative (EAEC) two enterotoxigenic (ETEC)] were used obtain mutants. The mutation in presence rifaximin, rifampicin ciprofloxacin was established by growth on plates containing serial dilutions antibiotic above bacterial MIC. determine rifaximin resistance, 28 selected resistant grown for 20...
Positively-charged amino acids are located at specific positions in the envelope glycoprotein E2 of hepatitis C virus (HCV): two histidines (H) and four arginines (R) conserved WHY one RGERCDLEDRDR motifs, respectively. Additionally, hypervariable region 1 (HVR1) is rich basic acids. To investigate role(s) these residues HCV entry, we subjected to comparative infection sedimentation analysis cell culture-produced (HCVcc, genotype 2a) wild type virus, a panel alanine single-site mutants...
Aims: This study sought to analyze the molecular mechanisms contributing development of rifaximin (Rfx) resistance in vitro Escherichia coli. Twenty-eight Rfx-resistant mutants as well four clinical isolates E. coli were analyzed. The results obtained show that mutations rpoB gene and overexpression Phe-Arg-β-naphthylamide (PAβN)-inhibitible efflux pump implicated Rfx resistance. Results: Amino acid substitutions at position 516 β-subunit RNA polymerases most frequently (53.6% mutants)....
The introduction of the genotype 2a isolate JFH1 was a major breakthrough in field hepatitis C virus (HCV), allowing researchers to study complete life cycle cell culture. However, fully competent culture systems encompassing most therapeutically relevant HCV genotypes are still lacking, especially for highly drug-resistant 1b. For isolated clones, efficient replication cultured hepatoma cells requires replication-enhancing mutations. such mutations may interfere with viral assembly, as...
Neutralizing antibody (nAb) activity during the course of natural infection is believed to be crucial combating virus propagation. The aim this study was measure impact nAb response on HCV early kinetics and genetic evolution in liver transplantation (LT) setting. A cohort 28 patients undergoing LT for HCV-related cirrhosis included study. Viral load, titers hypervariable region 1 (HVR1) sequences were determined serum samples obtained before at different time points after LT. Serum assessed...