A5044533521- Glioma Diagnosis and Treatment
- Head and Neck Cancer Studies
- Brain Metastases and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Advanced Radiotherapy Techniques
- Lung Cancer Research Studies
- Cancer Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Urinary and Genital Oncology Studies
- Esophageal Cancer Research and Treatment
- Prostate Cancer Treatment and Research
- Bladder and Urothelial Cancer Treatments
- Oral health in cancer treatment
- Head and Neck Surgical Oncology
- Meningioma and schwannoma management
- Prostate Cancer Diagnosis and Treatment
- Cancer-related cognitive impairment studies
- Management of metastatic bone disease
- Tracheal and airway disorders
- Ear and Head Tumors
- Colorectal Cancer Surgical Treatments
- Radiation Therapy and Dosimetry
- Cancer Genomics and Diagnostics
- Cancer survivorship and care
Générale-Beaulieu Clinic
2023-2024
University Hospital of Geneva
2013-2023
Hôpital Beau-Séjour
2013-2019
University of Toronto
2016-2017
Princess Margaret Cancer Centre
2016-2017
Geneva College
2012-2016
University of Geneva
2011
Sapienza University of Rome
2010
Osteoradionecrosis (ORN) of the mandible is a late toxicity affecting patients treated with radiotherapy for head and neck malignancies. To authors' knowledge, ORN has no standardized grading system its reporting based on retrospective findings in heterogeneous patient populations. The rate era intensity-modulated (IMRT) still unknown.The authors report incidence from prospectively collected data regarding 1196 who were diagnosed squamous cell carcinoma oropharynx curative-intent IMRT, or...
BackgroundThe addition of bevacizumab to temozolomide-based chemoradiotherapy (TMZ/RT → TMZ) did not prolong overall survival (OS) in patients with newly diagnosed glioblastoma phase III trials. Elderly and frail are underrepresented clinical trials, but early reports suggested preferential benefit this population.Patients methodsARTE was a 2 : 1 randomized, multi-center, open-label, non-comparative II trial hypofractionated RT (40 Gy 15 fractions) (10 mg/kg×14 days) (arm A, N = 50) or...
To determine the diagnostic performance of FDG-PET/MRI with diffusion-weighted imaging (FDG-PET/DWIMRI) for detection and local staging head neck squamous cell carcinoma (HNSCC) after radio(chemo)therapy. This was a prospective study that included 74 consecutive patients previous radio(chemo)therapy HNSCC in whom tumour recurrence or radiation-induced complications were suspected clinically. The underwent hybrid PET/MRI examinations morphological MRI, DWI FDG-PET. Experienced readers blinded...
Abstract Somatic mutations in the isocitrate dehydrogenase genes IDH1 and IDH2 occur at high frequency several tumour types. Even though these are confined to distinct hotspots, we show that gliomas only type with an exceptionally percentage of R132H mutations. Patients harbouring mutated tumours have lower levels genome-wide DNA-methylation, associated increased gene expression, compared other IDH1/2 (“non-R132H mutations”). This reduced methylation is seen multiple types thus appears...
Abstract Background Modern techniques of radiotherapy are supposed to decrease the incidence osteoradionecrosis mandible (ORNM). The purpose this study was compare ORNM after intensity‐modulated (IMRT) in comparison conventional 3D conformal (conventional RT). Methods We conducted a retrospective consecutive unselected patients treated single institution between 2002 and 2012. To minimize confounding effects, only with oropharyngeal carcinoma without surgery primary site were included....
Stage III N2 non-small cell lung cancer (NSCLC) is a very heterogeneous disease associated with poor prognosis. A number of therapeutic options are available for patients NSCLC, including surgery [with neoadjuvant or adjuvant chemotherapy (CTx)/neoadjuvant chemoradiotherapy (CRT)] CRT potentially followed by immunotherapy. We have no clear evidence demonstrating significant survival benefit either these approaches, the selection between treatments not always straightforward and can come down...
To assess the outcome of patients treated with a dose-adapted salvage radiotherapy (SRT) protocol based on an endorectal magnetic resonance imaging (erMRI) failure definition model after radical prostatectomy (RP).We report 171 relapsing RP who had undergone erMRI before SRT. 64 Gy were prescribed to prostatic bed with, in addition, boost 10 suspected local relapse as detected 131 (76.6%).The 3-year biochemical relapse-free survival (bRFS), survival, distant metastasis-free cancer-specific...
Background The dosimetric advantage of prostate-rectum spacers to displace the anterior rectal wall outside high-dose radiation regions has been clearly established in prostate cancer radiotherapy (RT). aim this study was assess impact hydrogel spacer (HS) interfraction motion patients undergoing RT for cancer.Material and methods Twenty implanted with three fiducial markers (FM) (n = 10) or without HS were analyzed. Displacements between isocenter based on FM's position bony anatomy...
To explore a prognostic or predictive role of MRI and O-(2-18F-fluoroethyl)-L-tyrosine (18FET) PET parameters for outcome in the randomized multicenter trial ARTE that compared bevacizumab plus radiotherapy with radiotherpay alone elderly patients glioblastoma.Patients isocitrate dehydrogenase wild-type glioblastoma ages 65 years older were included this post hoc analysis. Tumor volumetric apparent diffusion coefficient (ADC) analyses serial scans from 67 18FET-PET tumor-to-brain intensity...
To assess treatment toxicity and patients' survival/quality of life (QoL) after volumetric modulated arc therapy (VMAT) with simultaneous in-field boost (SIB) for cancer patients 1 - 4 brain metastases (BM) treated or without surgery. Between March December 2010, 29 BM (total volume BM, < 40 cm3) aged 80 years, KPS ≥ 70, RPA III were included in this prospective trial. Whole VMAT (30 Gy) a SIB to the (40 was delivered 10 fraction. Mean age 62.1 ± 8.5 years. Fifteen (51.7%) underwent MMSE...
Background. To assess treatment tolerance by patients treated with a dose-adapted salvage radiotherapy (SRT) protocol based on an multiparametric endorectal magnetic resonance imaging (erMRI) failure definition model after radical prostatectomy (RP). Material and methods. A total of 171 prostate cancer recurring RP undergoing erMRI before SRT were analyzed. median dose 64 Gy was delivered to the prostatic bed (PB) with, in addition, boost 10 suspected relapse as visualized 131 (76.6%)....
Motion management is crucial for optimal stereotactic body radiotherapy (SBRT) of moving targets. We aimed to describe our clinical experience with real-time tracking lung-specific electromagnetic transponders (EMTs) SBRT early stage non-small cell lung cancer in free-breathing (FB) or deep inspiration breath-hold (DIBH).Seven patients were implanted EMTs. Simulation was performed FB and DIBH. prescribed 60 Gy 3, 5 8 fractions the tumor delivered volumetric modulated arcs a 6 MV flattening...
Background and Purpose: Larynx cancer represents one of the most frequently diagnosed head neck malignancies, which is often confined to glottic area. The aim this study was report oncological outcome identify prognostic factors in early-stage squamous cell carcinoma treated with radiotherapy. Material Methods: Patients (n=761) 10 centers between 1990 2015 were retrospectively analyzed. Probabilities loco-regional control (LRC) overall survival (OS) calculated possible analyzed using Cox...
Transurethral resection of bladder tumor (TURBT), radiotherapy, chemotherapy, or combinations can be used in patients with muscle-invasive cancer (MIBC) not undergoing cystectomy. Nevertheless, unfitness for cystectomy is frequently associated other therapeutic modalities. We report the outcome MIBC who did undergo and receive cisplatin-based chemotherapy. Selection criteria study were nonmetastatic MIBC, no cystectomy, Chemotherapy and/or radiotherapy should have been aside from TURBT....
Abstract Background The management of meningiomas is challenging, and the role postoperative radiotherapy not standardized. Methods Radiation oncology experts in Swiss centres were asked to participate this decision-making analysis on use (RT) for meningiomas. Experts from ten agreed provided their treatment algorithms. Their input was converted into decision trees based objective consensus methodology. used as a basis identify discrepancies clinical routine. Results Several criteria RT...
Objectives The aim of the current study was to compare a neoadjuvant regimen containing oxaliplatin with standard preoperative treatment for rectal cancer. Methods From December 2006 2007, 20 patients cancer were treated at our Institution weekly addition (50 mg/m 2 ) radiotherapy (50.4–54.0 Gy in 28–30 daily fractions) and continuous infusion 5-fluorouracil (200 ). results compared historical control group including 21 consecutive previously from 2004 October 2006. Results Both rate...
Rectal cancer typically necessitates a combination of radiotherapy (RT), chemotherapy, and surgery. The associated functional disorders reduction in quality life have led to an increasing interest organ preservation strategies. Response strongly correlates with RT dose, but dose escalation external beam remains limited even modern techniques because toxicity the surrounding tissues. This study reports on use Papillon, endocavitary Radiotherapy device, treatment rectal cancer. device delivers...