A5024218687- Extracellular vesicles in disease
- Microbial Fuel Cells and Bioremediation
- Anaerobic Digestion and Biogas Production
- Ferroptosis and cancer prognosis
- Plant Parasitism and Resistance
- Bauxite Residue and Utilization
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Plant Molecular Biology Research
- Brain Metastases and Treatment
- Advanced battery technologies research
- Circular RNAs in diseases
- Aluminum Alloys Composites Properties
- Biofuel production and bioconversion
- Methane Hydrates and Related Phenomena
- Electrocatalysts for Energy Conversion
- Lung Cancer Research Studies
- Mine drainage and remediation techniques
- RNA modifications and cancer
- Water Treatment and Disinfection
- Plant nutrient uptake and metabolism
- Supercapacitor Materials and Fabrication
- Membrane-based Ion Separation Techniques
- Phosphorus and nutrient management
- Renal and related cancers
Hebei Medical University
2018-2025
Second Hospital of Hebei Medical University
2018-2025
Qingdao Institute of Bioenergy and Bioprocess Technology
2023-2024
Chinese Research Academy of Environmental Sciences
2019-2024
Chinese Academy of Sciences
2023-2024
China Three Gorges University
2024
Ministry of Education of the People's Republic of China
2024
University of Chinese Academy of Sciences
2024
Tsinghua University
2022-2023
Hospital of Hebei Province
2023
Treatments of glioblastoma (GBM) have not been very effective, largely due to the inefficiency drugs in penetrating blood brain barrier (BBB). In this study, we investigated potential exosome-coated doxorubicin (DOX)-loaded nanoparticles (ENPDOX) BBB penetration, inducing immunogenic cell death (ICD) and promoting survival GBM-bearing mice. DOX-loaded (NPDOX) were coated with exosomes prepared from mouse endothelial bEnd.3 cells. ENPDOX cellular uptake was examined. Penetration through...
SUMMARY Nitrogen (N) is an essential major nutrient for food crops. Although ammonium (NH 4 + ) the primary N source of rice ( Oryza sativa ), nitrate (NO 3 − can also be absorbed and utilized. Rice responds to NO application by altering its root morphology, such as elongation. Strigolactones (SLs) are important modulators length. However, roles SLs their downstream genes in ‐induced elongation remain unclear. Here, levels total SL (4‐deoxyorobanchol) responses seminal (SR) lengths NH were...
In response to the problems of poor degradability and mechanical properties liquid mulch, natural non-toxic polymer compound corn starch sodium alginate were used prepare fully biodegradable mulch. The preparation conditions mulch optimized, changes in microbial community soil with degradation analyzed. corn-starch–sodium-alginate-based film had an optimum performance at a tensile strength 0.145 MPa elongation break 16.05%, which was attained by adding 33.33% alginate, 50% glycerol 22 4%...
Abstract Leptomeningeal metastasis (LM) is a devastating complication of advanced non–small cell lung cancer (NSCLC). Its diagnosis and monitoring can be challenging. Recently, extracellular vesicle (EV) miRNAs have become new noninvasive diagnostic biomarker. The purpose this study was to examine the clinical value role EV in NSCLC-LM. Next-generation sequencing analysis revealed that with differential expression EVs sera patients NSCLC LM non-LM were detected identify biological markers...
Background Central nervous system (CNS) infections pose a fatal risk to patients. However, the limited sample volumes of cerebrospinal fluid (CSF) and low detection efficiency seriously hinder accurate pathogens using conventional methods. Methods We evaluated performance metagenomics next-generation sequencing (mNGS) in diagnosing CNS infections. CSF samples from 390 patients clinically diagnosed with were used for mNGS cell-free DNA (cfDNA) ( n =394) whole-cell (wcDNA) =150). Results The...
Leptomeningeal carcinomatosis (LC) is a severe complication in the advanced stage of lung adenocarcinoma, with an extremely poor prognosis. Currently, diagnosis LC poses challenges. Serum exosomal miRNAs (microRNAs) have been demonstrated to possess potential as viable biomarkers. However, their value remains unclear. In this study, serum samples were collected from adenocarcinoma patients LC. The control groups consisted early-stage and advanced-stage without exosomes isolated for high -...
Background and Objective: Exosomes communicate inter-cellularly miRNAs play critical roles in this scenario. MiR-214-5p was implicated multiple tumors with diverse functions uncovered. However, whether miR-214-5p is mechanistically involved glioblastoma, especially via exosomal pathway, still elusive. Here we sought to comprehensively address the role of glioblastoma (GBM) microenvironment. Methods: The relative expression determined by real-time PCR. Cell viability migration were measured...
Abstract Background Leptomeningeal metastases (LM) were rare in gastric cancer (GC), and GC patients with LM (GCLM) generally suffer from poor prognosis. Nevertheless, the clinical utility of cerebrospinal fluid (CSF) circulating tumor DNA (ctDNA) was underinvestigated GCLM. Methods We retrospectively studied 15 GCLM patients, all had paired primary tissue samples post-LM CSF while 5 also plasma samples. All analyzed using next-generation sequencing (NGS), molecular features correlated...
Ammonia inhibition often occurs during anaerobic digestion (AD) of the protein-rich substrate. Iron-containing substances were proved to be efficient in alleviating ammonia stress. However, mechanisms behind, especially distinct impacts different forms iron materials, are not fully revealed. Here, performances FeCl3 and Fe3O4 on AD systems under stress investigated. Moreover, behind these revealed compared at transcriptional level. Results showed that additions with an equal amount element...
Objective. To investigate the value of neutrophil to lymphocyte ratio (NLR), platelet (PLR), and red blood cell distribution width (RDW) in evaluating prognosis children with severe pneumonia (SP). Methods. A retrospective analysis data 91 SP admitted our hospital from March 2018 2021. According survival status after 28 days treatment, all were divided into group (n = 59) death 32). The clinical laboratory indicators patients recorded. Multivariate logistic regression was used analyze risk...