A5020343509- Genetic diversity and population structure
- Evolution and Genetic Dynamics
- Plant and animal studies
- Animal Behavior and Reproduction
- Genetic Associations and Epidemiology
- Bioinformatics and Genomic Networks
- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Plant Pathogens and Fungal Diseases
- Genomics and Phylogenetic Studies
- Genetic Mapping and Diversity in Plants and Animals
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Biotin and Related Studies
- Aquaculture disease management and microbiota
- Physiological and biochemical adaptations
- Ecology and Vegetation Dynamics Studies
- Evolution and Paleontology Studies
- Fungal and yeast genetics research
- Identification and Quantification in Food
- Zoonotic diseases and public health
- Protein Structure and Dynamics
- Chromosomal and Genetic Variations
- Plant Taxonomy and Phylogenetics
- Microbial Metabolic Engineering and Bioproduction
University of North Carolina at Chapel Hill
2020-2024
University of Connecticut
2024
The University of Texas at Austin
2016-2022
Trigenic interactions in yeast link bioprocesses To dissect the genotype-phenotype landscape of a cell, it is necessary to understand between genes. Building on digenic protein-protein interaction network, Kuzmin et al. created trigenic by using synthetic genetic array (see Perspective Walhout). Triple-mutant analyses indicated that majority genes with associations functioned within same biological processes. These converged networks identified landscape. Although overall effects were weaker...
The evolution of postzygotic reproductive isolation is an important component speciation. But before complete there sometimes a phase heterosis in which hybrid fitness exceeds that the two parental species. genetics and have typically been studied isolation, precluding development unified theory Here, we develop model incorporates both positive negative gene interactions, accounts for isolation. We parameterize with recent data on effects 10,000 mutations yeast, singly pairwise epistatic...
Recombination often differs markedly between males and females. Here we present the first analysis of sex-specific recombination in Gasterosteus sticklebacks. Using whole-genome sequencing 15 crosses G. aculeatus nipponicus, localized 698 crossovers with a median resolution 2.3 kb. We also used bioinformatic approach to infer historical sex-averaged patterns for both species. is greater females than on all chromosomes, overall map length 1.64 times longer The locations differ strikingly...
With the rise of affordable next-generation sequencing technology, introgression-or exchange genetic materials between taxa-has become widely perceived to be a ubiquitous phenomenon in nature. Although this claim is supported by several keystone studies, no thorough assessment frequency introgression across eukaryotes nature has been performed date. In manuscript, we aim address knowledge gap examining patterns eukaryotes. We collated single statistic, Patterson's D, which can used as test...
Intralocus sexually antagonistic selection occurs when an allele is beneficial to one sex but detrimental the other. This form of thought be key evolution chromosomes hard detect. Here we perform analysis phased young look for signals in Japan Sea stickleback (Gasterosteus nipponicus). Phasing allows us date suppression recombination on chromosome and provides unprecedented resolution identify recombining region chromosome. We four windows with elevated divergence between X Y region, all or...
The genomic era has made clear that introgression, or the movement of genetic material between species, is a common feature evolution. Examples both adaptive and deleterious introgression exist in variety systems. What unclear how fitness an introgressing haplotype changes as species diverge size changes. In simple model, we show may more easily occur into parts genome which have not diverged heavily from ancestor. key insight alleles shared background are likely to positive epistatic...
Chromosomal inversions are frequently implicated in isolating species. Models have shown how can evolve the context of postmating isolation. Inversions also associated with mating preferences, a topic that has not been studied theoretically. Here, we show spread by capturing preference locus and one or more loci involved epistatic incompatibilities. be established under broad conditions ranging from near panmixis to nearly complete speciation. These results provide hypothesis explain growing...
Abstract Despite a century of genetic analysis, the evolutionary processes that have generated patterns exceptional and phenotypic variation in model organism Drosophila melanogaster remains poorly understood. In particular, how is partitioned within its putative ancestral range Southern Africa unresolved. Here, we study population structure, admixture, spatial structuring candidate incompatibility alleles across global sample, including 223 new accessions, predominantly from remote regions...
ABSTRACT With the rise of affordable next generation sequencing technology, introgression — or exchange genetic materials between taxa is widely perceived to be a ubiquitous phenomenon in nature. Although this claim supported by several keystone studies, no thorough assessment on frequency nature has been performed date. In manuscript, we aim address knowledge gap providing meta-analysis most comprehensive survey studies Eukaryotes date (724 papers with claims introgression). We first...
ABSTRACT Despite a century of genetic analysis, the evolutionary history underlying patterns exceptional and phenotypic variation in model organism Drosophila melanogaster remains poorly understood. How is partitioned across range D. , particularly its putative ancestral Subtropical Africa, unresolved. Here, we assess population structure, admixture, mate preference, incompatibility global sample, including 174 new accessions from remote regions within Africa. While almost all Out Africa...
Abstract Blastomyces is an emerging primary fungal pathogen that affects patients worldwide. The evolutionary processes have resulted in the current diversity genus remain largely unexplored. We used whole genome sequences from 99 isolates, including two sequenced this study using long-read technologies, to infer phylogenetic relationships between species. find five different methods trees. Additionally, we gene tree discordance along with differences relative placement of several species...
Blastomyces spp. fungi, the causal agent of blastomycosis, are common in North America but do occur other areas world. The most prevalent pathogen genus is B. dermatitidis. Most dermatitidis isolates originate from America, there sporadic reports recovery Africa and Asia. High-quality that incorporate genetic information about fungus outside have been rare. Genome sequencing 3 fungal patients India with chronic respiratory diseases revealed belong to a genetically differentiated lineage...
Genome structural differences, such as inversions, are extremely common between species and within populations. Theoretical models of how why inversions evolve have affirmed that they able to under both adaptive nonadaptive scenarios (reviewed in Kirkpatrick, 2010). What has remained difficult, however, is distinguishing these from each other. In this issue Molecular Ecology , Connallon Olito (2022) present a model examines lead different distributions inversion sizes. The authors several...
Abstract The genomic era has made clear that introgression, or the movement of genetic material between species, is a common feature evolution. Examples both adaptive and deleterious introgression exist in variety systems. What unclear how fitness an introgressing haplotype changes as species diverge, size changes. In simple model, we show early process divergence, large haplotypes can be favored more than individual alleles. key insight alleles from shared background are likely to have...