A5030575593- Pineapple and bromelain studies
- Phytochemical compounds biological activities
- Toxoplasma gondii Research Studies
- Herpesvirus Infections and Treatments
- Developmental Biology and Gene Regulation
- Malaria Research and Control
- Plant Molecular Biology Research
- Rabies epidemiology and control
- Psychological and Temporal Perspectives Research
- Microtubule and mitosis dynamics
- Biological Research and Disease Studies
- Neurobiology and Insect Physiology Research
- Circadian rhythm and melatonin
- Hippo pathway signaling and YAP/TAZ
- Neurogenesis and neuroplasticity mechanisms
- Drug Transport and Resistance Mechanisms
- Insect Pest Control Strategies
- Multicomponent Synthesis of Heterocycles
- Cytomegalovirus and herpesvirus research
- Mosquito-borne diseases and control
Champalimaud Foundation
2017
Instituto Gulbenkian de Ciência
2006-2012
University of Lisbon
2007-2012
Instituto de Medicina Molecular João Lobo Antunes
2006
Abstract Sleeping sickness is a fatal disease caused by Trypanosoma brucei , unicellular parasite that lives in the bloodstream and interstitial spaces of peripheral tissues brain. Patients have altered sleep/wake cycles, body temperature, endocrine profiles, but underlying causes are unknown. Here, we show robust circadian rhythms mice become phase advanced upon infection, with abnormal activity occurring during rest phase. This shortening period both at behavioral level as well tissue cell...
The intracellular parasite Toxoplasma has an indirect life cycle, in which felids are the definitive host. It been suggested that this developed mechanisms for enhancing its transmission rate to by inducing behavioral modifications intermediate rodent For example, Toxoplasma-infected rodents display a reduction innate fear of predator odor. However, animals with infection acquired wild more often caught traps, suggesting there manipulations host behavior beyond those increase predation...
Neural progenitors in the vertebrate nervous system are fully polarized epithelial cells, with intercellular junctions at apical region. These progenitor cells remain within neuroepithelium throughout neurogenesis, and will ultimately give rise to all neurons mature system. We have addressed role of PAR polarity complex neuroepithelial show that PAR3 functions as initial scaffold assemble organize region coordinating also recruitment additional complexes junction-associated proteins same...
Abstract Toxoplasma gondii infects a broad range of hosts and can establish chronic infections with the formation brain cysts. Infected animals show altered risk behaviour which has been suggested to increase capture probability hosts, thus enhance parasite transmission. It proposed that ability cysts secrete tyrosine hydroxylase could mediate these behavioural alterations. We tested involvement secreted hydroxylase, coded by AaaH2 gene, in development alterations mouse behaviour, generating...
Plasmodium sporozoites are transmitted by Anopheles mosquitoes and infect hepatocytes, where a single sporozoite replicates into thousands of merozoites inside parasitophorous vacuole. The nature the Plasmodium-host cell interface, as well interactions occurring between these two organisms, remains largely unknown. Here we show that highly dynamic hepatocyte actin reorganization events occur around developing berghei parasites human hepatoma cells. Actin is most prominent 10 to 16 hours post...