A5058819661- Microbial Fuel Cells and Bioremediation
- Photosynthetic Processes and Mechanisms
- Neurological disorders and treatments
- Context-Aware Activity Recognition Systems
- Parkinson's Disease Mechanisms and Treatments
- Neural dynamics and brain function
- Neural and Behavioral Psychology Studies
- Neurotransmitter Receptor Influence on Behavior
- ATP Synthase and ATPases Research
- Herpesvirus Infections and Treatments
- Receptor Mechanisms and Signaling
- Botulinum Toxin and Related Neurological Disorders
- Toxoplasma gondii Research Studies
- Cytomegalovirus and herpesvirus research
- Hemoglobin structure and function
- Control Systems and Identification
- Aerospace and Aviation Technology
- Child and Adolescent Psychosocial and Emotional Development
- Neurobiology and Insect Physiology Research
- Protein Structure and Dynamics
- Health Systems, Economic Evaluations, Quality of Life
- Gaze Tracking and Assistive Technology
- Transplantation: Methods and Outcomes
- NMR spectroscopy and applications
- Rabies epidemiology and control
Champalimaud Foundation
2014-2024
Instituto de Medicina Molecular João Lobo Antunes
2024
Weatherford College
2024
University of Lisbon
2011-2024
Centre Hospitalier Universitaire de Toulouse
2024
Instituto de Aeronáutica e Espaço
2024
Instituto Gulbenkian de Ciência
2012
Universidade Nova de Lisboa
2008-2011
The intracellular parasite Toxoplasma has an indirect life cycle, in which felids are the definitive host. It been suggested that this developed mechanisms for enhancing its transmission rate to by inducing behavioral modifications intermediate rodent For example, Toxoplasma-infected rodents display a reduction innate fear of predator odor. However, animals with infection acquired wild more often caught traps, suggesting there manipulations host behavior beyond those increase predation...
Abstract Animals exhibit a diverse behavioural repertoire when exploring new environments and can learn which actions or action sequences produce positive outcomes. Dopamine release after encountering reward is critical for reinforcing reward-producing 1–3 . However, it has been challenging to understand how credit assigned the exact that produced dopamine during continuous behaviour. Here we investigated this problem in mice using self-stimulation paradigm specific spontaneous movements...
Gs (Geobacter sulfurreducens) can transfer electrons to the exterior of its cells, a property that makes it preferential candidate for development biotechnological applications. Its genome encodes over 100 cytochromes and, despite their abundance and key functional roles, date there is no structural information these proteins in solution. The trihaem cytochrome PpcA might have crucial role conversion electronic energy into protonmotive force, fundamental step ATP synthesis presence...
Miniaturised and wearable sensor-based measurements enable the assessment of PD motor-related features like never before hold great promise as non-invasive biomarkers for early accurate diagnosis, monitoring progression PD. High fidelity human movement reconstruction simulation can already be conducted in a clinical setting with increasingly precise affordable motion technology enabling access to high quality labelled data on patients' subcomponents (kinematics kinetics). At same time,...
Abstract Toxoplasma gondii infects a broad range of hosts and can establish chronic infections with the formation brain cysts. Infected animals show altered risk behaviour which has been suggested to increase capture probability hosts, thus enhance parasite transmission. It proposed that ability cysts secrete tyrosine hydroxylase could mediate these behavioural alterations. We tested involvement secreted hydroxylase, coded by AaaH2 gene, in development alterations mouse behaviour, generating...
The bacteria belonging to the genus Shewanella are facultative anaerobes that utilize a variety of terminal electron acceptors which includes soluble and insoluble metal oxides. tetraheme c-type cytochrome isolated during anaerobic growth frigidimarina NCIMB400 (Sfc) contains 86 residues is involved in Fe(III) reduction pathways. Although functional properties Sfc redox centers quite well described, no structures available for this protein. In work, we report solution structure reduced form...
Cytochrome c3 from Desulfovibrio desulfuricans ATCC 27774 appears to be capable of receiving two protons and electrons hydrogenase for transport the membrane, converting electronic energy into proton motive force. Detailed studies mechanism require control both redox state protonation protein; hence, structure determination protein in solution by NMR is preferred method. This work compares structures protonated fully oxidized reduced states as a first step toward elucidating pH-dependent...
Abstract Explicit information obtained through instruction profoundly shapes human choice behaviour. However, this has been studied in computationally simple tasks, and it is unknown how model-based model-free systems, respectively generating goal-directed habitual actions, are affected by the absence or presence of instructions. We assessed behaviour a novel variant more complex decision-making task, before after providing about task structure, both healthy volunteers individuals suffering...
The Human Activity Recognition (HAR) systems require objective and reliable methods that can be used in the daily routine must offer consistent results according to performed activities. In this work, a framework for human activity recognition accelerometry (ACC) based on our previous work with new features techniques was developed. set covered wavelets, the CUIDADO implementation Log Scale Power Bandwidth creation. Hidden Markov Models were also applied clustering output. Forward...
<title>Abstract</title> Background Despite the long-term efficacy of high-frequency (HFS) subthalamic nucleus deep brain stimulation (STN-DBS) on appendicular symptoms, its benefit freezing gait (FOG) is less clear. Mechanisms and optimal therapeutic approaches to this type FOG remain unclear. Objective Assess acute post-surgery response levodopa Methods 17 PD STN-DBS patients with a score (item 3.11) ≥ 2 in MedON/StimON condition were evaluated under 5 experimental conditions, including low...
Abstract The aim of this paper is providing an experimental procedure system identification Unmanned Aerial System (UAS) with fixed flexible wing using subspace techniques for dynamic systems. A reliable model important aerodynamic and flight control systems to comprehend the behavior design a feedback loop that can be applied minimize effects structural flexibility. In scenario, research intended identify parametric aircraft from open-loop data applying DSR e algorithm. test campaign was...
Childhood adversities have been linked to poor health outcomes in adults, including both mood and general medical disorders. Here we tested the hypothesis that childhood specifically increase risk of comorbidity between disorders, rather than increasing either one independently.Mood disorders (DSM-IV major depressive, dysthymic bipolar disorders), were assessed 2060 adults WHO World Mental Health Survey Portugal. Discrete-time survival analyses used investigate association subsequent...
Recent advances in neuroscience made it possible for people to issue commands with their brains via non-invasive electroencephalography electrodes. Such have already been used online control of various dynamic systems. Current research activities aim at assessing if this technology could successfully be applied aircraft control. For purpose, a flight controller that uses the output brain machine interfaces (BMI) provide over light airplane's path, was designed. Subsequent pilot-in-the-loop...
Abstract Animals exhibit a diverse behavioral repertoire when exploring new environments and can learn which actions or action sequences produce positive outcomes. Dopamine release upon encountering reward is critical for reinforcing reward-producing 1–3 . However, it has been challenging to understand how credit assigned the exact that produced dopamine during continuous behavior. We investigated this problem with novel self-stimulation paradigm in specific spontaneous movements triggered...
Introduction Methods for measuring cognitive reserve (CR) are limited and controversial. Dual task cost (DTC) paradigms, assessing links between gait cognition, increasingly regarded as robust measures of CR. Objectives Here, we aimed to validate a simplified methodology DTC paradigm in healthy volunteers application clinical settings measurement We tested if subtracting by 7's (cognitive task) while walking (motor induced sample 39 young adults. For the task, recorded number correct...