A5023977492- Venomous Animal Envenomation and Studies
- Rabies epidemiology and control
- Amphibian and Reptile Biology
- Marine Invertebrate Physiology and Ecology
- Ichthyology and Marine Biology
- Vector-borne infectious diseases
- Healthcare and Venom Research
- Biochemical and Structural Characterization
- Aquaculture disease management and microbiota
- Insect and Pesticide Research
- Turtle Biology and Conservation
- Ion channel regulation and function
- Glycosylation and Glycoproteins Research
- Antimicrobial Peptides and Activities
- Toxin Mechanisms and Immunotoxins
- Galectins and Cancer Biology
Universidade Federal do Rio de Janeiro
2010-2025
National Institute of Science and Technology for Structural Biology and Bioimaging
2010-2025
Instituto Vital Brazil (Brazil)
2007-2025
Instituto Butantan
2020
Fundação Oswaldo Cruz
2005-2007
High hydrostatic pressure (HHP) has been used for viral inactivation to facilitate vaccine development when immunogenicity is maintained or even increased. In this work, we HHP inactivate Bothrops jararacussu venom. Our protocol promotes the loss of decrease in many biological activities Horses were immunized with pressurized venom, and contrast native procedure does not induce any damage animals. Furthermore, serum obtained venom efficiently neutralized all B. Antibody titrations higher...
A combination of anti-bothropic and anti-crotalic sera has been reported to be more effective in neutralizing the effects Bothrops jararacussu venom than serum alone. The role proteins from B. horse immune response was evaluated via analysis cross-reactivity with homologous heterologous sera. Many were identified 2D gel electrophoresis. Western blots revealed that anti-jararacussu showed higher reactivity l-aminoxidase (LAOs) snake metalloproteinase, (SVMPs) weaker towards Snake serine...
Bothrops, Crotalus and Lachesis represent the most medically relevant genera of pitvipers in Central South America. Similarity venom phenotype physiopathological profile envenomings caused by four nominal species led us to hypothesize that an antivenom prepared against from any them may exhibit paraspecificity all other congeneric taxa.To assess this hypothesis, work we have applied antivenomics immunochemical methods investigate immunoreactivity three monovalent antivenoms two polyvalent...
Snakebite treatment requires administration of an appropriate antivenom that should contain antibodies capable neutralizing the venom. To achieve this goal, production must start from a suitable immunization protocol and proper venom mixtures. In Brazil, against South American rattlesnake (Crotalus durissus terrificus) bites is produced by public institutions based on guidelines defined regulatory agency Brazilian Ministry Health, ANVISA. However, each institution uses its own mixture...
Snakes of the genus Bothrops, popularly known as pit vipers, are responsible for most cases snakebite in Brazil. Within this genus, Bothrops jararacussu and B. jararaca deserve special attention due to severity their bites inhabiting densely populated areas. Regarding treatment snakebites by jararacussu, questions have been raised about effectiveness specific bothropic antivenom neutralizing myotoxic effects; however, there no accurate data humans. Thus, development a differential diagnostic...
For over a century, polyclonal antibodies have been used to treat snakebite envenoming and are still considered by the WHO as only scientifically validated treatment for snakebites. Nevertheless, moderate innovations introduced this immunotherapy. New strategies approaches understanding how recognize neutralize snake toxins represent challenge next-generation antivenoms. The neurotoxic activity of Micrurus venom is mainly due two distinct protein families, three-finger (3FTx) phospholipases...