A5066622602- Amyloidosis: Diagnosis, Treatment, Outcomes
- Lipid Membrane Structure and Behavior
- Protein Structure and Dynamics
- Glaucoma and retinal disorders
- Cellular transport and secretion
- Caveolin-1 and cellular processes
- Surgical Sutures and Adhesives
- Hernia repair and management
- Erythrocyte Function and Pathophysiology
- Intestinal and Peritoneal Adhesions
- Intraocular Surgery and Lenses
- Protein Kinase Regulation and GTPase Signaling
- 14-3-3 protein interactions
- Signaling Pathways in Disease
- Nerve injury and regeneration
- Skin and Cellular Biology Research
- MicroRNA in disease regulation
- Nutritional Studies and Diet
- Complement system in diseases
- Electrospun Nanofibers in Biomedical Applications
- COVID-19 Pandemic Impacts
- Polyoxometalates: Synthesis and Applications
- Amyotrophic Lateral Sclerosis Research
- Invertebrate Immune Response Mechanisms
- Physiological and biochemical adaptations
Yokohama City University
2017-2024
Seikagaku Corporation (Japan)
1999-2024
Central Research Laboratories (United Kingdom)
2021
Josai University
2017
Osaka University
2001
Resource Development Institute
1989
Phospholipids are asymmetrically distributed in the plasma membrane (PM), with phosphatidylcholine and sphingomyelin abundant outer leaflet. However, mechanisms by which their distribution is regulated remain unclear. Here, we show that transmembrane protein 63B (TMEM63B) functions as a structure-responsive lipid scramblase localized at PM lysosomes, activating bidirectional translocation upon changes curvature thickness. TMEM63B contains two intracellular loops palmitoylated cysteine...
Abstract The principal effect controlling the oxygen affinity of vertebrate haemoglobins (Hbs) is allosteric switch between R and T forms with relatively high low respectively. Uniquely among jawed vertebrates, crocodilians possess Hb that shows a profound drop in presence bicarbonate ions. This allows them to stay underwater for extended periods by consuming almost all present blood-stream, as metabolism releases carbon dioxide, whose conversion hydrogen ions catalysed carbonic anhydrase....
The n-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic (DHA), found in fish oil, exert a number of beneficial effects, they are used the treatment hyperlipidemia. In recent years, EPA DHA have been to affect cancer cell proliferation. present study, PC3 cells, which androgen-independent prostate cells that resemble castration-resistant were investigate possible novel for cancer. cultured incubated with various concentrations or DHA. Cancer proliferation was confirmed by trypan...
The degeneration of intervertebral disc (IVD) is a major cause low back pain. However, there no satisfactory preventive treatment for degenerative disease (DDD). In this study, we examined the effects novel cross-linked hyaluronate hy
The effects of cross-linked hyaluronate hydrogel and liquid sodium on post-surgical adhesion reformation were examined using a rabbit model. Primary adhesions in the ileocaecal region Japanese white rabbits induced by mechanical chemical irritants during laparotomy. After 1 month primary lysed microsurgery or was applied to lesions. 10-14 days area measured assess any inhibitory effect test materials. Rabbits treated with showed significant reduction compared physiological saline treatment,...
No AccessJournal of UrologyINVESTIGATIVE UROLOGY1 Aug 2001EFFECTS OF SODIUM HYALURONATE ON EPITHELIAL HEALING THE VESICAL MUCOSA AND FIBROSIS IN RABBITS WITH ACETIC ACID INDUCED CYSTITIS KATSUYA TAKAHASHI, JUN TAKEUCHI, TOYOMI SATOSHI MIYAUCHI, KATSUYUKI HORIE, and YASUO UCHIYAMA TAKAHASHIKATSUYA TAKAHASHI Financial interest and/or other relationship with Seikagaku Corp. More articles by this author , TAKEUCHIJUN TAKEUCHI TAKAHASHITOYOMI MIYAUCHISATOSHI MIYAUCHI HORIEKATSUYUKI HORIE...
SeviL is a recently isolated lectin found to bind the linear saccharides of ganglioside GM1b (Neu5Ac[Formula: see text](2-3)Gal[Formula: text](1-3)GalNAc[Formula: text](1-4)Gal[Formula: text](1-4)Glc) and its precursor, asialo-GM1 (Gal[Formula: text](1-4)Glc). The crystal structures recombinant have been determined in presence absence ligand. protein belongs [Formula: text]-trefoil family, but shows only weak sequence similarity known structures. forms dimer solution, with one binding site...
Postoperative adhesion often develops as a natural physiological response following abdominal and pelvic surgeries. Although existing resorbable barriers have reduced the incidence of postoperative formation, their clinical efficacy requires improvement. In this study, we generated novel cross-linked, powder-formed chondroitin sulfate (SI-449) an effective anti-adhesion barrier. We evaluated its effect in animal models surgeries elucidated mechanism action.
Phospholipids are asymmetrically distributed in the plasma membrane (PM), and scramblases disrupt this asymmetry by shuffling phospholipids. We recently identified mouse Tmem63b as a structure‐responsive scramblase. belongs to TMEM63/OSCA family of ion channels; however, conservation scramblase activity within remains unclear. expressed human TMEM63 paralogs, TMEM63B orthologs, plant OSCA1.1 ‐deficient pro‐B cells found that vertebrate orthologs exhibit at PM. Previously, ten pathogenic...
Retention durability, especially in the eye, is one of most important properties ophthalmic viscosurgical devices (OVDs) during ocular surgery. However, information on physical OVDs insufficient to explain their retention durability. The purpose this study clarify mechanism OVD improve understanding behavior To elucidate retention, we have developed a new test method for measuring repulsive force. As result, maximum force was positively and well correlated with durability investigated OVDs....
Abstract Directed evolution can rapidly achieve dramatic improvements in the properties of a protein or bestow entirely new functions on it. We have discovered strong correlation between probability finding productive mutation at particular position and chemical shift perturbation Nuclear Magnetic Resonance spectra upon addition an inhibitor for reaction it promotes. In proof-of-concept study we converted myoglobin, non-enzymatic protein, into most active Kemp eliminase reported to date...