A5014938888- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Radiopharmaceutical Chemistry and Applications
- Single-cell and spatial transcriptomics
- Cancer-related molecular mechanisms research
- COVID-19 Clinical Research Studies
- Pancreatic and Hepatic Oncology Research
- Pancreatic function and diabetes
- SARS-CoV-2 and COVID-19 Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Chromosomal and Genetic Variations
- Respiratory viral infections research
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Sperm and Testicular Function
- Cell Image Analysis Techniques
- Genetic diversity and population structure
- Diabetes and associated disorders
- Electronic Health Records Systems
- Social Policies and Healthcare Reform
- COVID-19 Impact on Reproduction
- Antibiotic Use and Resistance
- Ferroptosis and cancer prognosis
- Extracellular vesicles in disease
- Nursing Diagnosis and Documentation
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2019-2023
German Cancer Research Center
2017-2023
Heidelberg University
2017-2023
Bayer (Germany)
2023
Freie Universität Berlin
2020-2022
Charité - Universitätsmedizin Berlin
2010-2022
Humboldt-Universität zu Berlin
2020
University of Konstanz
2018-2019
University of Lübeck
2007
The SARS-CoV-2 pandemic affecting the human respiratory system severely challenges public health and urgently demands for increasing our understanding of COVID-19 pathogenesis, especially host factors facilitating virus infection replication. was reported to enter cells via binding ACE2, followed by its priming TMPRSS2. Here, we investigate ACE2 TMPRSS2 expression levels their distribution across cell types in lung tissue (twelve donors, 39,778 cells) derived from subsegmental bronchial...
Molecular evidence of cellular heterogeneity in the human exocrine pancreas has not been yet established because local concentration and cascade hydrolytic enzymes that can rapidly degrade cells RNA upon pancreatic resection. We sought to better understand composition neonates adults healthy diseased conditions using single-cell sequencing approaches.We innovated single-nucleus RNA-sequencing protocols profiled more than 120,000 from pancreata adult neonatal donors. validated findings...
The testis produces gametes through spermatogenesis and evolves rapidly at both the morphological molecular level in mammals1-6, probably owing to evolutionary pressure on males be reproductively successful7. However, evolution of individual spermatogenic cell types across mammals remains largely uncharacterized. Here we report analyses single-nucleus transcriptome data for testes from 11 species that cover three main mammalian lineages (eutherians, marsupials monotremes) birds (the...
Sex chromosomes differentiated from different ancestral autosomes in various vertebrate lineages. Here, we trace the functional evolution of XY Chromosomes green anole lizard ( Anolis carolinensis ), on basis extensive high-throughput genome, transcriptome and histone modification sequencing data revisit dosage compensation representative mammals birds with substantial new expression data. Our analyses show that sex represent an ancient system originated at least ≈160 million years ago...
SUMMARY The SARS-CoV-2 pandemic affecting the human respiratory system severely challenges public health and urgently demands for increasing our understanding of COVID-19 pathogenesis, especially host factors facilitating virus infection replication. was reported to enter cells via binding ACE2, followed by its priming TMPRSS2. Here, we investigate ACE2 TMPRSS2 expression levels their distribution across cell types in lung tissue (twelve donors, 39,778 cells) derived from subsegmental...
Genomic drift affects the functional properties of cell lines, and reproducibility data from in vitro studies. While chromosomal aberrations mutations single pivotal genes are well explored, little is known about effects minor, possibly pleiotropic, genome changes. We addressed this question for human dopaminergic neuronal precursor line LUHMES by comparing two subpopulations (SP) maintained either at American-Type-Culture-Collection (ATCC) or original provider (UKN). Drastic differences...
Abstract Single-cell RNA sequencing (scRNA-seq) is the leading technique for charting molecular properties of individual cells. The latest methods are scalable to thousands cells, enabling in-depth characterization sample composition without prior knowledge. However, there important differences between scRNA-seq techniques, and it remains unclear which most suitable protocols drawing cell atlases tissues, organs organisms. We have generated benchmark datasets systematically evaluate...
Computer-assisted decision support systems (CDSS) are designed to improve infection management. The aim of this prospective, clinical pre- and post-intervention study was investigate the influence CDSS on management severe sepsis septic shock in intensive care units (ICUs). Data were collected for a total 180 days during two periods 2006 2007. Of 186 patients with or shock, 62 stratified into low adherence standards group (LAG) 124 high (HAG). ICU mortality significantly increased LAG versus...
Abstract Molecular evidence of cellular heterogeneity in the human exocrine pancreas has not been established, due to local concentration hydrolytic enzymes that can rapidly degrade cells and RNA upon resection. Here we innovated single-nucleus sequencing protocols, profiled more than 120,000 from adult neonatal donors create first comprehensive atlas cells, including epithelial non-epithelial constituents. Adult pancreata shared common features, presence previously undetected acinar...
The testis is a key male reproductive organ that produces gametes through the process of spermatogenesis. Testis morphologies and spermatogenesis evolve rapidly in mammals, presumably due to evolutionary pressure on males be reproductively successful 1,2 . rapid evolution was shown reflected at molecular level based bulk-tissue work 3-8 , but individual spermatogenic cell types across mammalian lineages remains largely uncharacterized. Here we report analyses single-nucleus transcriptome...
Single-cell analysis of healthy lung tissue and cancer reveals distinct tumor cell populations, including cells with differential immune modulating capacity between smokers never smokers, which could guide future therapeutic strategies.
Der vorliegende Beitrag bietet einen Überblick über die Entwicklung der medizinischen Rehabilitation bei Post-COVIDSyndrom (PCS) in Trägerschaft Deutschen Rentenversicherung (DRV). Als Basis dienten Routine-Daten, aus dem einheitlichen Reha-Entlassungsbericht gewonnen werden. Berücksichtigt wurden hierbei nur Rehabilitationen nach § 15 SGB VI, d.h. Personen, sich im erwerbsfähigen Alter befinden. Es handelt um eine Querschnittsanalyse aller PCS DRV, den Jahren 2021 bis 2023 abgeschlossen...
<div>Abstract<p>Lung cancer remains the leading cause of cancer-related death worldwide, despite declining smoking prevalence in industrialized countries. Although lung is highly associated with status, a significant proportion cases develop patients who have never smoked, an observable bias toward female smokers. A better understanding heterogeneity and immune system involvement during tumor evolution progression smokers therefore needed. Here, we used single-nucleus...
Supplementary Data from Intratumoral Heterogeneity and Immune Modulation in Lung Adenocarcinoma Female Smokers Never
Supplementary Data from Intratumoral Heterogeneity and Immune Modulation in Lung Adenocarcinoma Female Smokers Never
Supplementary Data from Intratumoral Heterogeneity and Immune Modulation in Lung Adenocarcinoma Female Smokers Never
Supplementary Data from Intratumoral Heterogeneity and Immune Modulation in Lung Adenocarcinoma Female Smokers Never
Supplementary Data from Intratumoral Heterogeneity and Immune Modulation in Lung Adenocarcinoma Female Smokers Never
Supplementary Data from Intratumoral Heterogeneity and Immune Modulation in Lung Adenocarcinoma Female Smokers Never
Supplementary Data from Intratumoral Heterogeneity and Immune Modulation in Lung Adenocarcinoma Female Smokers Never