A5006990201- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis C virus research
- Cancer, Lipids, and Metabolism
- Pancreatic and Hepatic Oncology Research
- Multiple and Secondary Primary Cancers
- COVID-19 Clinical Research Studies
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
Hospital de Clínicas "José de San Martín"
2018-2023
University of Buenos Aires
2022-2023
Hospital de Clínicas
2018
We aim to describe the efficacy, safety profile, and variables associated with survival in patients hepatocellular carcinoma (HCC) treated sorafenib South America.Sorafenib has been shown improve advanced HCC. There are few data on use for HCC America.We performed a retrospective analysis of cases from 8 medical centers 5 American countries, between January 2010 June 2017. The primary endpoint was overall (OS), which defined as time initiation death or last follow-up. Risk factors decreased...
Failures at any step in the hepatocellular carcinoma (HCC) surveillance process can result HCC diagnostic delays and associated worse prognosis. We aimed to estimate prevalence of failure its risk factors patients with Argentina, considering three steps: 1) recognition at-risk patients, 2) implementation surveillance, 3) success surveillance. performed a multi-center cross-sectional study for Argentina seen between10.01.2018 10.30.2019. Multivariable logistic regression analysis was used...
To achieve WHO's goal of eliminating hepatitis C virus (HCV), innovative strategies must be designed to diagnose and treat more patients. Therefore, we aimed describe an implementation strategy identify patients with HCV who were lost follow-up (LTFU) offer them re-linkage care. We conducted study utilizing a contact not under regular in 13 countries from Latin America. Patients identified by the international classification diseases (ICD-9/10) or equivalent. Medical records then reviewed...
In Argentina, it is estimated that around 50% of patients infected with hepatitis C virus (HCV) have been diagnosed and only 5% those accessed treatment after several months; this reality got worse the pandemic. World Health Organization proposed a global health sector strategy to eliminate HCV as public threat by 2030. Key elements elimination plan include increased diagnosis access. This study aimed describe implementation "Relinkage simplified care pathway program" for micro-elimination...
To achieve WHO's goal of eliminating HCV, innovative strategies must be designed to diagnose and treat more patients. This study aimed describe an implementation strategy identify patients with HCV who were lost follow-up (LTFU) offer them re-linkage Figure 1. Analysis global DNA methylation. A) Representative dot blot using anti-5mC which recognizes methylated DNA, anti-IgG as negative control methylene blue staining total loading control. B) Graphs shows mean ± standard deviation 5mC...
Hepatitis C virus infection is one of the main causes morbidity and mortality worldwide. In Argentina, it estimated that only 50% infected people are diagnosed; these, half have confirmed their diagnosis, 5% access to treatment. The COVID-19 pandemic has exacerbated this situation, further decreasing context, we developed a program reconnect simplify patient care cascade, in order facilitate treatment, monitoring complications associated with hepatitis infection. 24.2% re-engaged patients...
Introduction: Late detection of hepatocellular carcinoma (HCC) due to suboptimal surveillance with ultrasound is a major problem worldwide but further importance in resource-limited settings. Blood biomarkers are urgently needed and currently alpha-fetoprotein (AFP) the only accepted biomarker. However, AFP has poor accuracy for early HCC mainly been studied resource-rich We prospectively investigated circulating immune markers detect 2 different groups Latin American patients acting as...
Failures at any step in the hepatocellular carcinoma (HCC) surveillance process can result HCC diagnostic delays and associated worse prognosis. We aimed to estimate prevalence of failure its risk factors patients with Argentina, considering three steps: 1) recognition at-risk patients, 2) implementation surveillance, 3) success surveillance. performed a multi-center cross-sectional study for Argentina seen between10.01.2018 10.30.2019. Multivariable logistic regression analysis was used...