A5100599627- Colorectal Cancer Treatments and Studies
- Systemic Lupus Erythematosus Research
- Neurological disorders and treatments
- Mental Health Treatment and Access
- Rheumatoid Arthritis Research and Therapies
- Parkinson's Disease Mechanisms and Treatments
- Viral gastroenteritis research and epidemiology
- RNA Interference and Gene Delivery
- Hepatocellular Carcinoma Treatment and Prognosis
- Clostridium difficile and Clostridium perfringens research
- Ocular Surface and Contact Lens
- Psychiatric care and mental health services
- Suicide and Self-Harm Studies
- Functional Brain Connectivity Studies
- Microscopic Colitis
- Adenosine and Purinergic Signaling
- Advanced MRI Techniques and Applications
- Diagnosis and treatment of tuberculosis
- Discourse Analysis in Language Studies
- Connexins and lens biology
- Cardiac electrophysiology and arrhythmias
- Hepatitis C virus research
- Chronic Lymphocytic Leukemia Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Second Language Acquisition and Learning
Bengbu Medical College
2025
Second Military Medical University
2025
National Yang Ming Chiao Tung University
2021-2024
Second Affiliated Hospital of Zhejiang University
2023-2024
China Agricultural University
2023
Chung Hwa University of Medical Technology
2023
Guangzhou University of Chinese Medicine
2022
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2022
Xuzhou Medical College
2021
Tianjin University of Science and Technology
2018
Cellular senescence occurs as a response to extracellular and intracellular stresses contributes aging age-related pathologies. Emerging evidence suggests that cellular also acts potent tumor suppression mechanism prevents the oncogenic transformation of primary human cells. Recent reports have indicated miRNAsact key modulators by targeting critical regulators pathways. We previously reported miR-127 is up-regulated in senescent fibroblasts. In this report, we identified novel regulator...
In this article, we have addressed the recent published article by Wang et al which examines risk factors associated with surgical site infections (SSIs) and evaluates effectiveness of prophylactic antibiotics in their prevention. identified several significant SSIs, including age ≥ 60 years, diabetes mellitus, complications such as insufficient cystic duct stump closure, gallbladder perforation, empyema, postoperative hematoma. Their findings suggest that can serve a protective factor...
Abstract Transverse-tubules (T-tubules) play pivotal roles in Ca 2+ -induced, release and excitation–contraction coupling cardiomyocytes. The purpose of this study was to uncover mechanisms where sarco/endoplasmic reticulum ATPase (SERCA2a) improved cardiac function through T-tubule regulation during myocardial ischemia/reperfusion (I/R). SERCA2a protein expression, cytoplasmic [Ca ] i , calpain activity, junctophilin-2 (JPH2) expression intracellular localization, cardiomyocyte T-tubules,...
Abstract Dopamine replacement therapy (DRT) represents the standard treatment for Parkinson's disease (PD), however, instant and long‐term medication influence on patients' brain function have not been delineated. Here, a total of 97 drug‐naïve patients, 43 patients under DRT, 94 normal control (NC) were, retrospectively, enrolled. Resting‐state functional magnetic resonance imaging data motor symptom assessments were conducted before after levodopa challenge test. Whole‐brain connectivity...
Pulmonary tuberculosis (PTB) causes a considerable number of deaths in China; however, the factors related to mortality are not well known.To determine among PTB patients and explore its risk Shanghai, China.This was retrospective population-based study. A cohort who initiated treatment district Shanghai from 2004 2015 evaluated. Mortality studied using standardised ratio (SMR) Cox's proportional hazards model.Of 2741 recruited our study, 394 (14.4%) died during 12-year follow-up. The...
Memristor is an increasingly important research field for in-memory computing (IMC) due to its significant potential in neuromorphic computing. A resistive memristor that can integrate components with nonvolatility and high-density features, such as spintronics, would be a great blessing the IMC technology. We demonstrate Pt/Co/NiO device exhibited multilevel perpendicular exchange bias (EB) switching (RS) behaviors. It arose from modulated Co-NiO coupling formation/breaking of conductive...
Abstract Objective This study aimed to explore the knowledge, self-efficacy, and attitudes toward suicide prevention among nurses with different demographic characteristics. Methods A cross-sectional descriptive design was adopted, conducted between August September 2020. The content of questionnaire included basic demographics, prevention. Correlation analysis performed determine nurses’ Results sample comprised 778 nursing staff from a medical center in southern Taiwan. results showed that...
Whether there is hypothalamic degeneration in Parkinson's disease (PD) and its association with clinical symptoms pathophysiological changes remains controversial. We aimed to quantify microstructural hypothalamus using a novel deep learning-based tool patients PD those probable rapid-eye-movement sleep behavior disorder (pRBD). further assessed whether these associated free thyroxine (FT4) levels. This study included 186 PD, 67 pRBD, 179 healthy controls. Multi-shell diffusion MRI were...
Rheumatoid arthritis (RA) is a heterogeneous chronic disease. RA patients should start disease modifying anti-rheumatic drugs (DMARDs) therapy immediately after diagnosis. If first-line treatment with conventional synthetic DMARDs does not relieve the disease, biology and targeted are options for patients. Patients can switch to different types of biological if remission achieved. However, difficult-to-treat RA, achieving stabilization failure multiple clinical challenge that needs be...
Abstract C 34 H 36 CdN 8 O 7 , monoclinic, P 2 1 / n (no. 14), a = 14.863(3) Å, b 13.184(3) c 17.202(3) β 91.33(3)°, V 3369.8(12) Å 3 Z 4, R gt ( F ) 0.0311, wR ref 0.0825, T 113(2) K.
Fatty liver disease is now the second most common after viral hepatitis, and its increasing prevalence younger age of onset are posing a serious threat to human health worldwide. However, as early fatty reversible disease, diagnosis has an important impact on timely treatment measures. The majority current fat prediction methods have high threshold understanding, some indicators influencing factors difficult obtain, which does not meet public's need for daily self-monitoring content...
For using targeted covalent inhibitors (TCIs) as anticancer and antiviral drugs, we establish that the model compounds PCMPS (p-chloromercuriphenyl sulfate) PCMB (p-chloromercuribenzoate) are of DEDDh family exonucleases. The underlying mechanism is analyzed by X-ray crystallography, activity/nucleic acid-binding assays, all-atom molecular dynamics (MD) simulations. first TCI-complexed structures a enzyme, Lassa fever virus NP exonuclease (NPexo), resolved to elucidate Cys409 binding site...
Rheumatoid arthritis (RA) is a joint-disabling inflammatory disease associated with the pathology of synovitis. Some patients RA are difficult to treat, using disease-modifying anti-rheumatic drugs (DMARDs). Biology and targeted synthetic DMARDs (b/tsDMARDs) options for RA. Acquired immunodeficiency syndrome (AIDS) an infectious caused by human virus (HIV). Adalimumab anti-tumor necrosis factor therapy commonly used in However, there no reports or related data on RA-HIV/AIDS treated...
3610 Background: Recently, early tumor shrinkage (ETS) was reported to predict outcome in metastatic colorectal cancer treated with cetuximab (cet). This study evaluate the impact of ETS on long-term patients (pts) wild-type-KRAS unresectable CLLM receiving cet plus chemotherapy (CT, FOLFIRI or mFOLFOX6). Methods: 138 pts a randomized controlled trial (70 armA received CT and 68 armB alone) previously (Jianmin et al, ESMO 2012, abstract-557, ClinicalTrials.gov, number NCT01564810) were...
Although is a frequently used subordinating conjunction in English. However, non-nativeness often observed Chinese EFL learners’ although output during pedagogical practice. This paper aims at exploring the characteristics of employment writing. The study corpus-based analysis launched under analytical framework contrastive interlanguage analysis. hypothesis lays theoretical foundation present study. Texts from two corpora—the learner English corpus [CLEC] and “arts humanities” disciplinary...
3616 Background: The optimal time from surgery to the start of chemotherapy in colon cancer is unknown. We evaluated impact on survival intraportal (IPC) administrated during plus adjuvant (AC) as treatment for stage II and III cancer. Methods: Patients with or were randomly assigned receive IPC mFOLFOX6 (OCTREE) alone. primary end point was disease-free (DFS). Secondary endpoints included metastasis-free (MFS), overall (OS) safety. Results: intent-to-treat population comprised 237 patients....