A5080880469- Luminescence Properties of Advanced Materials
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Nanoparticle-Based Drug Delivery
- interferon and immune responses
- Chemokine receptors and signaling
- Cancer-related molecular mechanisms research
- Perovskite Materials and Applications
- Immune cells in cancer
- Digital Transformation in Industry
- Chronic Kidney Disease and Diabetes
- Nanoplatforms for cancer theranostics
- Circular RNAs in diseases
- Cancer Mechanisms and Therapy
- Advanced Manufacturing and Logistics Optimization
- Advanced Photocatalysis Techniques
- 2D Materials and Applications
- Phagocytosis and Immune Regulation
- Inorganic Fluorides and Related Compounds
- Ammonia Synthesis and Nitrogen Reduction
- RNA and protein synthesis mechanisms
- Immunotherapy and Immune Responses
- RNA regulation and disease
- Glass properties and applications
National Tsing Hua University
2017-2025
University of California, Davis
2024
University of California Davis Medical Center
2024
National Yang Ming Chiao Tung University
2014-2023
Institute of Biological Chemistry, Academia Sinica
2022
Wuhan Institute of Technology
2019-2020
Chang Gung Memorial Hospital
2018
National Taiwan University
2012
While immunotherapy holds great promise for combating cancer, the limited efficacy due to an immunosuppressive tumor microenvironment and systemic toxicity hinder broader application of cancer immunotherapy. Here, we report a combinatorial approach that uses highly efficient tumor-selective gene carrier improve anticancer circumvent toxicity. In this study, engineered tumor-targeted lipid-dendrimer-calcium-phosphate (TT-LDCP) nanoparticles (NPs) with thymine-functionalized dendrimers exhibit...
A new Eu3+-activated oxyfluoride phosphor Ca12Al14O32F2:Eu3+ (CAOF:Eu3+) was synthesized by a solid state reaction. Commonly red line emission detected in the range of 570–700 nm. To achieve requirement illumination, this study revealed crystal chemistry approach to reduce Eu ions from 3+ 2+ lattice. Replacing Al3+–F– appreciate dopant Si4+–O2– is adopted enlarge activator site that enables Eu3+ be reduced. The crystallization samples examined powder X-ray diffraction (XRD) and high...
Significance A highly selective, safe, and potent CXCR4 antagonist, BPRCX807, has been designed experimentally validated in various hepatocellular carcinoma models. Through combination therapy, it can synergize with either a kinase (e.g., sorafenib) or checkpoint inhibitor (e.g. anti–PD-1) to augment effectiveness of current anticancer treatments. With its unique mode action, new strategy for preventing cell migration metastasis is provided.
Extracellular vesicles (EVs) are released by cells to mediate intercellular communication under pathological and physiological conditions. While small EVs (sEVs; <100-200 nm, exosomes) intensely investigated, the properties functions of medium large (big (bEVs); >200 microvesicles) less well explored. Here, bEVs sEVs identified as distinct EV populations, it is determined that in a greater bEV:sEV ratio aggressive human triple-negative breast cancer (TNBC) subtype. PalmGRET,...
Successful siRNA therapy requires suitable delivery systems with targeting moieties such as small molecules, peptides, antibodies, or aptamers. Galactose (Gal) residues recognized by the asialoglycoprotein receptor (ASGPR) can serve potent for hepatocellular carcinoma (HCC) cells. However, efficient to HCC via galactose rather than normal liver tissues in patients remains a challenge. To achieve more HCC, we synthesized various galactoside derivatives and investigated capability of...
The remarkable narrow-band emission of trivalent lanthanide-doped phosphors excited by the vacuum ultraviolet (VUV) radiation lines Xe atoms/Xe2 molecules at 147/172 nm are extensively investigated in development plasma display panels and Hg-free fluorescent lamps, which frequently used our daily lives. Numerous solid materials, particularly Tb3+-doped oxides, such as silicates, phosphates borates, efficient green/blue sources with color-tunable properties. excitation wavelength rare earth...
The anticancer efficacy of TNF‐related apoptosis‐inducing ligand (TRAIL)‐based therapy is limited because systemic toxicity, poor bioavailability, and development TRAIL resistance. We developed a tumor‐targeted LCPP (lipid/calcium/phosphate/protamine) nanoparticle (NP) to deliver plasmid DNA (pDNA) into hepatocellular carcinoma (HCC) cells in mouse model HCC. pDNA was encapsulated pH stimuli‐responsive calcium phosphate (CaP) core, protamine added facilitate nuclear delivery pDNA. In...
Abstract Background Metastasis and chemoresistance are major culprits of cancer mortality, but factors contributing to these processes incompletely understood. Methods Bioinformatics methods were used identify the relations Smyca expression clinicopathological features human cancers. RNA-sequencing analysis was reveal -regulated transcriptome. RNA pull-down immunoprecipitation examine binding Smad3/4 c-Myc/Max. Chromatin chromatin isolation by purification determine transcription various...
In various autoimmune diseases, dysfunctional TREX1 (Three prime Repair Exonuclease 1) leads to accumulation of endogenous single-stranded DNA (ssDNA), double-stranded (dsDNA) and DNA/RNA hybrids in the cytoplasm triggers immune activation through cGAS-STING pathway. Although inhibition could be a useful strategy for cancer immunotherapy, profiling cellular functions terms its potential substrates is key step. Particularly important functionality processing RNA substrates. The exonuclease...
For using targeted covalent inhibitors (TCIs) as anticancer and antiviral drugs, we establish that the model compounds PCMPS (p-chloromercuriphenyl sulfate) PCMB (p-chloromercuribenzoate) are of DEDDh family exonucleases. The underlying mechanism is analyzed by X-ray crystallography, activity/nucleic acid-binding assays, all-atom molecular dynamics (MD) simulations. first TCI-complexed structures a enzyme, Lassa fever virus NP exonuclease (NPexo), resolved to elucidate Cys409 binding site...
Extracellular vesicles (EVs) are released by cells to mediate intercellular communication under pathological and physiological conditions. While small EVs (sEVs; <100–200 nm, exosomes) intensely investigated, the properties functions of medium large (big [bEVs]; >200 microvesicles) less well explored. Here, we identify bEVs sEVs as distinct EV populations, determine that in a greater bEV:sEV ratio aggressive human triple-negative breast cancer (TNBC) subtype. PalmGRET, bioluminescence...
todefects are related to multiple inflammation and autoimmune disorders.A long-standing mystery is how TREX1 -overhang excision in DNA repair dsDNA degradation immune silencing.Here, the molecular basis of such unique catalytic activities established by crystal structure analyses bound with a variety or damaged nucleotides.We found that Leu24-Pro25-Ser26 cluster serves cap non---overhang it wedges into duplex region for degradation.We also revealed behaviours acting on lesions various...