A5044201284- Hepatitis C virus research
- Viral Infections and Vectors
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Viral Infections and Outbreaks Research
- Mosquito-borne diseases and control
- Brucella: diagnosis, epidemiology, treatment
- Fire effects on ecosystems
- Vector-borne infectious diseases
- Hepatitis Viruses Studies and Epidemiology
- Vector-Borne Animal Diseases
- Burkholderia infections and melioidosis
- Surgical site infection prevention
- Streptococcal Infections and Treatments
- HIV/AIDS drug development and treatment
- Bacillus and Francisella bacterial research
- Galectins and Cancer Biology
- Liver Disease and Transplantation
- Pharmacovigilance and Adverse Drug Reactions
- Atherosclerosis and Cardiovascular Diseases
- Historical Turkish Studies
- Leptospirosis research and findings
- Nosocomial Infections in ICU
- Multidisciplinary Science and Engineering Research
- Paraoxonase enzyme and polymorphisms
Textile Institute of Pakistan
2023
Tokat Gaziosmanpaşa Üniversitesi
2011-2022
Global Viral
2020
Antalya Eğitim ve Araştırma Hastanesi
2016
Serum ferritin is one of the markers indicating hemophagocytosis that may have a role in pathogenesis Crimean-Congo hemorrhagic fever (CCHF). This study was designed to determine any correlation between serum and routine diagnostic laboratory CCHF, investigate relationship levels disease severity.Sixty-six patients with CCHF admitted hospital during spring summer months 2006 2007 were included study. measured sera obtained initial days hospitalization. Data from 53 showing decreasing...
The aim of this retrospective study was to evaluate the efficacy vacuum-assisted closure (VAC) and GranuFoam Silver® dressing (KCI, San Antonio, TX) compared with conventional GranuFoam® in management diabetic foot ulcers.Twenty-one consecutive patients treated or silver-coated foam were reviewed retrospectively. wound duration 6 mo. Group 1 (n=10) received (GranuFoam) group 2 (n=11) (GranuFoam Silver). surface area, treatment, bacteriology, recurrence between groups. mean age 61.70±10.52 y...
In this study, we aimed to investigate whether quantitative HBsAg and alanine aminotransferase (ALT) levels correlated with Hepatitis B Virus (HBV) DNA in patients HBeAg negative chronic HBV infection.Ninetynine were divided into two groups; inactive carriers (IC) active (AC) DNA>2000 IU/mL. These groups compared terms of ALT levels. Quantitative measurements performed Elecsys II Quant assay (Roche Diagnostic).Mean age was 43.11±14.79 years. values IC AC 2.47±1.35 log10 IU/mL, 3.59±0.97...
We report the first tularemia epidemic occurring in Tokat Province, located Middle Black Sea Region of Turkey, and some features cases. This has allowed calculation attack rate this disease because its appearance a single large family.The clinical laboratory patients were examined. For serological diagnosis, microagglutination assays done on serum samples from other members family.Seven family developed overt (one ulceroglandular, six oropharyngeal). Three had conjunctivitis addition to...
Tokat province and Kelkit Valley located in the Black Sea region of Turkey are endemic areas for brucellosis Crimean-Congo hemorrhagic fever. Since risk factors similar, probability Coxiella burnetii seroposititivity is assumed to be also high this area. The aim study was investigate Q fever seropositivity patients with acute A total 53 (37 male, 16 female; age range: 18-65 years, mean age: 47.13 ± 16.40 years) who were admitted emergency room infection diseases outpatient clinics...
Crimean-Congo hemorrhagic fever infection (CCHF) is a viral zoonosis. The pathogenesis of this disease has not been established so far, however, cytokines account for its progression and outcome. aim the present study to investigate association between chemokine receptor 5 (CCR5) gene Δ32 mutation pathogenity, severity, mortality CCHF. This case-control included 133 CCHF patients diagnosed by detection CCHV RNA positivity 97 healthy control subjects. CCR5 analyzed polymerase chain reaction...
Crimean Congo Haemorrhagic Fever (CCHF) is a fatal viral haemorrhagic fever affecting humans. Serious CCHF outbreaks with high mortality have been reported from Asia, Africa and Europe. Endemic seen in Turkey between 2002 2009, about 5% rate. People working animals, people having tick bites, health workers relatives of patients may be infected by virus therefore they considered as risk groups. In the present study, prevalence control group, animals (PA), bites (PT), (HW) (RP) Tokat province...
Background/Aims: mbitasvir/paritaprevir/ritonavir (OMV/PTV/r) ± dasabuvir (DSV) ribavirin (RBV) combination has demonstrated excellent rates of sustained virologic response (SVR) and a very good safety profile in patients with the chronic hepatitis C virus (HCV) genotype 1 or 4 infections.We aimed to investigate effectiveness OMV/PTV/r DSV RBV regimen real-world clinical practice.Materials Methods: Data from HCV treated (n=862) 34 centers across Turkey between April 1, 2017 August 31, 2018...
In this study, we evaluated the relationship of hepatitis B virus (HBV) DNA levels with liver histology and various other related parameters predictors histologically active disease requiring treatment (Histological activity ≥6 and/or grade ≥2 by Ishak's classification) in patients HBeAg negative chronic HBV infection. Demographic data, laboratory findings no clinical cirrhosis who underwent biopsy considering (HBV >2000 IU/mL) were analyzed. Two hundred fifteen included retrospective study....
Abstract Pegylated or non‐pegylated α‐interferon are frequently used medications for the treatment of both chronic hepatitis B and C. Skin disorders, which mainly comprised eczematous dermatitis, seen during with this drug. However, drug eruption morbilliform eruptions due to interferons have been rarely reported so far. We herein describe a patient who developed under pegylated interferon. She was able continue after switching from interferon conventional
Objective: This case-control study was designed to determine the risk factors for hepatitis C virus transmissions in Middle Black Sea Region of Turkey. Material and Methods: One hundred ninety-three anti-HCV positive patients were eligible number control group 190. The individuals each questioned having a possible role transmission virus. data evaluated statistically by Chi-square logistic regression analysis. Results: Among cases, 78% females. There no significant difference terms gender...
Objective: Increased serum ferritin (SF) levels are encountered in various conditions, such as inflammatory syndromes and haemochromatosis. Interferon alpha is one of the stimulants SF. In this study we aimed to evaluate SF changes patients with chronic hepatitis C (CHC) during antiviral therapy, relationship between treatment response. Methods: Data from a total 97 who had received peginterferon (PEG-IFN) plus ribavirin combination therapy for CHC, been followed up more than 6 months after...
Interferon-α based therapy for chronic hepatitis C (CHC) is associated with thyroiditis and thyroid dysfunction (TD). This study investigated whether TD during pegylated interferon-α (PEG-IFN) plus ribavirin treatment favors sustained viral response (SVR), also the association between PEG-IFN formulations. retrospective was performed in CHC patients who had received been followed six months after treatment. Several factors were compared without TD. 119 included study. De novo incidence of...
Crimean-Congo hemorrhagic fever (CCHF) is a zoonotic viral disease. We aimed to investigate the cutaneous manifestations of CCHF and reveal their associations with fatality. Two hundred sixty-nine patients diagnosed were assessed. Skin findings observed in 170 (63.2%) patients. A facial rash was most common finding (n = 82, 30.5%). In severe cases, (petechiae ecchymoses) recognized. statistically significant correlation obtained between fatality, it determined that there strong positive...
<h2>Summary</h2><h3>Background</h3> Data describing the coagulopathy of Crimean–Congo haemorrhagic fever are scarce. We did rotational thromboelastometry (ROTEM) and conventional coagulation testing in patients with to increase our understanding this infectious disease. <h3>Methods</h3> a prospective observational cohort study adults aged 18 years older admitted hospitals PCR-confirmed Samsun Tokat, Turkey. Demographic, clinical, laboratory data were collected blood samples for ROTEM...
Objectives : Q fever, which is a zoonosis caused by Coxiella burnetii , may result in abortions infected animals and pregnant women. In our study, we searched the association between fever serology abortion region where endemic. Material Methods This study was conducted Gaziosmanpasa University Hospital (Tokat, Turkey) March May 2012. A total of 100 women, from these, 64 had history spontaneus (cases) 36 live births with no complicated obstetrics or partum (controls), enrolled study. Both...
In this study, associations between IL-4, IL-6, and macrophage migration inhibitory factor (MIF) polymorphisms susceptibility to brucellosis were investigated. Consecutive adult patients with no known treatment against who did not have any other autoimmune and/or chronic disorders, included in study (n = 120, Group I). Age sex-matched controls had disorders also healthy volunteers, II). The IL4_P2P2 genotype, IL4_P1 allele, IL4_variable number of tandem repeats (VNTR)_IL6-174CG compound...
Neuropsychiatric side effects of long-term recombinant interferon-α therapy consist a large spectrum symptoms.In the literature, cranial neuropathy, especially Bell's palsy, and movement disorders, have been reported much less often than other neurotoxic effects.We report case palsy in patient with chronic hepatitis C during peginterferon-α ribavirin therapy.The subsequently developed clinically inapparent facial nerve involvement on contralateral showed an increase choreic movements related...