A5020282380- Wnt/β-catenin signaling in development and cancer
- Cell Adhesion Molecules Research
- Galectins and Cancer Biology
- Immunotherapy and Immune Responses
- Melanoma and MAPK Pathways
- Single-cell and spatial transcriptomics
- Cancer Cells and Metastasis
- Agriculture and Biological Studies
- Hippo pathway signaling and YAP/TAZ
- Agricultural Productivity and Crop Improvement
- Protein Degradation and Inhibitors
- Spectroscopy Techniques in Biomedical and Chemical Research
- Peptidase Inhibition and Analysis
- Caveolin-1 and cellular processes
- Horticultural and Viticultural Research
Centre for Inflammation Research
2024
University of Edinburgh
2023-2024
Masaryk University
2021-2024
Garvan Institute of Medical Research
2023
Edinburgh Cancer Research
2023
RNF43 is an E3 ubiquitin ligase and known negative regulator of WNT/β-catenin signaling. We demonstrate that also a noncanonical WNT5A-induced signaling in human cells. Analysis the interactome using BioID immunoprecipitation showed can interact with core receptor complex components dedicated to Wnt pathway such as ROR1, ROR2, VANGL1, VANGL2. triggers VANGL2 ubiquitination proteasomal degradation clathrin-dependent internalization ROR1 inhibits ROR2 activation. These activities are...
The adhesion protein Kindlin-1 is over-expressed in breast cancer where it associated with metastasis-free survival; however, the mechanisms involved are poorly understood. Here, we report that promotes anti-tumor immune evasion mouse models of cancer. Deletion Met-1 mammary tumor cells led to regression following injection into immunocompetent hosts. This was a reduction infiltrating Tregs. Similar changes T cell populations were seen depletion polyomavirus middle antigen (PyV MT)-driven...
ABSTRACT As the core, tumorigenic downstream effectors of Hippo signalling pathway, YAP/TAZ and TEAD family transcription factors represent attractive targets for drug discovery efforts within cancer research. This is particularly true context pleural mesothelioma, in which there are many recent preclinical developments clinical trials evaluating efficacy inhibitors. The range inhibitors have shown great promise, but comparisons their performances so far limited. Here we develop a high...
Abstract Metastatic melanoma, a highly lethal form of skin cancer, presents significant clinical challenges due to limited therapeutic options and high metastatic capacity. Recent studies have demonstrated that cancer dissemination can occur earlier, before the diagnosis primary tumor. The progress in understanding kinetics is by lack animal models accurately mimic disease progression. We established xenograft model human melanoma spontaneously metastasizes lymph nodes lungs. This allows...
Fast-acquisition Raman methodologies such as stimulated scattering (SRS) and coherent anti-Stokes (CARS) microscopy, which generate image contrast using the active vibrational frequency of a given chemical, provide information on biochemical composition tissues. This has enabled detailed imaging interaction between tumor cells surrounding microenvironment (e.g. vasculature, stromal cells) without need for additional labelling. In addition, we have developed novel, highly spectroscopically...
Abstract RNF43 is a E3 ubiquitin ligase and known negative regulator of WNT/β-catenin signaling. We demonstrate that also noncanonical WNT5A-induced signaling in human cells. Analysis the interactome using BioID immunoprecipitation showed can interact with core receptor complex components dedicated to Wnt pathway such as ROR1, ROR2, VANGL1 VANGL2. triggers VANGL2 ubiquitination proteasomal degradation clathrin-dependent internalization ROR1 receptor. This activity physiologically relevant...