A5030865174- Health Systems, Economic Evaluations, Quality of Life
- Healthcare Policy and Management
- Healthcare cost, quality, practices
- Pharmaceutical Economics and Policy
- Primary Care and Health Outcomes
- Labor Movements and Unions
- Lymphoma Diagnosis and Treatment
- Cutaneous lymphoproliferative disorders research
- Pancreatitis Pathology and Treatment
- RNA and protein synthesis mechanisms
- Employment and Welfare Studies
- Quality and Safety in Healthcare
- Ethics in Clinical Research
- Cardiac Health and Mental Health
- Flood Risk Assessment and Management
- Digital Economy and Work Transformation
- Health and Medical Research Impacts
- Medical Coding and Health Information
- Homelessness and Social Issues
- Meta-analysis and systematic reviews
- Biotechnology and Related Fields
- HIV/AIDS Research and Interventions
- Mental Health Treatment and Access
- CAR-T cell therapy research
- Delphi Technique in Research
Cleveland Clinic London
2025
Royal London Hospital
2025
Manchester Royal Infirmary
2003-2024
Manchester University
2024
Queen Elizabeth Hospital Birmingham
1999-2024
University of Otago
2024
University of Birmingham
2010-2023
University of Regina
2012-2023
Fred Hutch Cancer Center
2023
The Ohio State University
2022
Analysis of the slowed turnover rates several specific mRNA species and higher cellular levels some these mRNAs in Saccharomyces cerevisiae lacking 5'-->3' exoribonuclease 1 (xrn1 cells) has led to finding that yeast contain amounts essentially full-length do not bind oligo(dT)-cellulose. On other hand, length poly(A) chains found after pulse-labeling cells exoribonuclease, rate synthesis oligo(dT)-bound mRNA, initial its deadenylation appeared quite similar same measurements wild-type...
Vol 1: Prostate hernia cataract dementia psychiatric disorders alcohol drugs learning disabilities family planning community child health. 2: Diabetes mellitus renal disease stroke lower respiratory coronary heart colorectal cancer lung hip replacements' knee replacements surgery repair varicose veins.
An exoribonuclease producing 5'-mononucleotides has been purified from ribosomes of Saccharomyces cerevisiae. The enzyme a broad pH optimum around 8.0, requires divalent cation, and is stimulated by monovalent cation with the degree stimulation being dependent on substrate used. With either poly(A) or rRNA as substrate, processive mode hydrolysis. oligonucleotides, (pA)3-5, are hydrolyzed enzyme, hydrolysis 5'-phosphate end group. Phosphorylation 3' little effect rate [3H]poly(A) [3H]rRNA,...
<b>Objective</b> To assess the validity of case mix adjustment methods used to derive standardised mortality ratios for hospitals, by examining consistency relations between risk factors and across hospitals. <b>Design</b> Retrospective analysis routinely collected hospital data comparing observed deaths with predicted Dr Foster Unit method. <b>Setting</b> Four acute National Health Service hospitals in West Midlands (England) adjusted ranging from 88 140. <b>Participants</b> 96 948 (April...
To compare the outcomes of home-based (using Heart Manual) and centre-based cardiac rehabilitation programmes.Randomised controlled trial parallel economic evaluation.Predominantly inner-city, multi-ethnic population in West Midlands, England.525 patients referred to four hospitals for following myocardial infarction or coronary revascularisation.A programme compared with programmes.Smoking cessation, blood pressure (systolic (SBP), diastolic (DBP)), total cholesterol (TC) high-density...
The National Institute for Health and Clinical Excellence (NICE) is a decision-maker. Where NICE reaches positive conclusion about the use of particular health technology (such as pharmaceutical product) in Service (NHS), there legal requirement service to make it available if patient's physician considers clinically appropriate [1]. Although this obligation does not apply technologies recommended NICE's clinical guidelines, still reasonable expectation by Care Quality Commission NHS...
Although acute hospitals offer a twenty-four hour seven day week service levels of staffing are lower over the weekends and some health care processes may be less readily available weekend. Whilst it is thought that emergency admission to hospital on weekend associated with an increased risk death, extent which this applies elective admissions well known. We investigated death in patients admitted versus weekdays. Retrospective statistical analysis routinely collected England, involving all...
A long-term dataset of reported flooding based on reports from the UK Met Office and Centre for Ecology Hydrology is described. This possibly a unique as authors are unaware any other 100+ year records flood events their consequences national scale. Flood classified by severity upon qualitative descriptions. There an increase in number over time associated with increased exposure to floodplain areas were developed. The data was de-trended exposure, using population dwelling house data....
Background Health inequalities exist for many disorders, but the contribution of deprivation to prevalence and outcome depressive symptoms in primary care populations has been infrequently studied. Aims To examine influence Jarman under-privileged area (UPA) scores on general practice patients. Method 18 414 patients attending 55 representative practices completed Hospital Anxiety Depression Scale a questionnaire employment status. Outcome those screening positive was assessed at 6 weeks...
Coronary artery stents are prosthetic linings inserted into coronary arteries via a catheter to widen the and increase blood flow ischaemic heart muscle. They used in treatment of disease (IHD). IHD is major cause morbidity mortality (123,000 deaths per annum) UK cost NHS. Clinical effects include subacute manifestations (stable unstable angina) acute (particularly myocardial infarction [MI]). Treatment includes attention risk factors, drug therapy, percutaneous invasive interventions (PCIs)...
To research the lay public's understanding of equipoise and randomisation in randomised controlled trials (RCTs) to look at why information on this may not be taken or remembered, as well effects providing designed overcome barriers.Investigations were informed by an update systematic review patients' consent clinical trials, relevant theory evidence from experimental psychology. Nine investigations conducted with nine participants.Access (return education), leisure vocational courses...
> “The general objective of such assessments is to improve knowledge about the potential impact a policy or programme, inform decision-makers and affected people, facilitate adjustment proposed in order mitigate negative maximize positive impacts.” > > European Centre for Health Policy1 The long tradition never considering on health public investment has ended. The white paper Saving Lives: Our Healthier Nation exhorted local decision makers “think effects which their policies have health,...
T he NHS R&D Health Technology Assessment (HTA) Programme was set up in 1993 to ensure that high-quality research information on the costs, effectiveness and broader impact of health technologies is produced
In this study, we describe the current state of Health Technology Assessment (HTA) system in England and Wales. This rests on a distinction between assessment appraisal has three main strands: researcher-led HTA, research development program, HTA-NICE (National Institute for Clinical Excellence) process. We outline pressures HTA how it evolved British National Service. discuss priorities are chosen, information is collected assessed, evidence used, make some observations about its impact....
The portion of the internal transcribed spacer 1 found on 20S pre-rRNA accumulates in Saccharomyces cerevisiae lacking 5'----3' exoribonuclease 1, showing that an endonucleolytic cleavage at 3' terminus 18S rRNA is involved to mature conversion. Smaller fragments sequence are also found. may be as a cytoplasmic RNase hydrolysis spacer.