A5100445917- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Renal Transplantation Outcomes and Treatments
- Intraoperative Neuromonitoring and Anesthetic Effects
- Scoliosis diagnosis and treatment
- Liver Disease Diagnosis and Treatment
- Knee injuries and reconstruction techniques
- Shoulder Injury and Treatment
- Cervical and Thoracic Myelopathy
- Sports injuries and prevention
- CAR-T cell therapy research
- Anesthesia and Pain Management
- Sports Performance and Training
- Vascular Procedures and Complications
- Pancreatic and Hepatic Oncology Research
- Hematopoietic Stem Cell Transplantation
- Viral-associated cancers and disorders
- T-cell and B-cell Immunology
- Pediatric Hepatobiliary Diseases and Treatments
- Psoriasis: Treatment and Pathogenesis
- Meningioma and schwannoma management
Dongguk University
2016-2025
University of Ulsan
2000-2024
Asan Medical Center
2004-2024
Ulsan College
2004-2024
Kyung Hee University
2008-2024
Kyung Hee University Hospital at Gangdong
2024
Seoul Medical Center
2024
Korea National University of Education
2023-2024
Gangdong University
2024
Hanyang University
2024
To investigate the impact of STA-21, a promising STAT-3 inhibitor, on development and progression inflammatory arthritis to determine possible mechanisms by which STA-21 has antiarthritic effects in interleukin-1 receptor antagonist-knockout (IL-1Ra-KO) mice, an animal model rheumatoid (RA).IL-1Ra-KO mice were treated with intraperitoneal injections (0.5 mg/kg) or vehicle 3 times per week for weeks. The mouse joints assessed clinical histologic features arthritis. CD4+CD25+FoxP3+ Treg cells...
IL-6-mediated STAT3 signaling is essential for Th17 differentiation and plays a central role in the pathogenesis of rheumatoid arthritis. To investigate molecular mechanism underlying antirheumatic effects T cell regulatory inhibition, we studied JAK 2 inhibitor AG490 on cell/regulatory (Treg) balance osteoclastogenesis. was administered to mice with collagen-induced arthritis (CIA) via i.p. injection, its vivo were determined. Differential expression proinflammatory cytokines, including...
Abstract Although several biomarkers can be used to distinguish cholangiocarcinoma (CCA) from healthy controls, differentiating the disease benign biliary (BBD) or pancreatic cancer (PC) is a challenge. CCA are associated with low specificity have not been validated in relation biological effects of CCA. In this study, we quantitatively analyzed 15 bile acids (n = 30), BBD 57) and PC 17) patients discovered glycocholic acid (GCA) taurochenodeoxycholic (TCDCA) as specific biomarkers. Firstly,...
Abstract Background Commercial anti-CD19 chimeric antigen receptor T-cell therapies (CART19) are efficacious against advanced B-cell non-Hodgkin lymphoma (NHL); however, most patients ultimately relapse. Several mechanisms contribute to this failure, including CD19-negative escape and CAR T dysfunction. All four commercial CART19 products utilize the FMC63 single-chain variable fragment (scFv) specific a CD19 membrane-distal epitope characterized by slow association (on) dissociation (off)...
The frustrated total internal reflection (FTIR) optical fingerprint scanning method is widely used due to its cost-effectiveness. However, image quality highly dependent on fingertip surface conditions, with moisture generally considered a degrading factor. Interestingly, prior study reported that excessive may improve quality, though their findings were based qualitative observations, necessitating further quantitative analysis. Additionally, since the FTIR relies principles, also...
Regulatory T cells play a key role in immune tolerance to self-antigens, thereby preventing autoimmune diseases. However, no drugs targeting Treg have been approved for clinical trials yet. Here, chimeric peptide is generated by conjugation of the cytoplasmic domain CTLA-4 (ctCTLA-4) with dNP2 intracellular delivery, dNP2-ctCTLA-4, and evaluated Foxp3 expression during Th0, Th1, Treg, Th17 differentiation dependent on TGF-β. The lysine motif ctCTLA-4, not tyrosine motif, required induction...
Objective The small molecule halofuginone has been shown to inhibit fibrosis, angiogenesis, and tumor progression. This study was undertaken evaluate the effects of in preventing autoimmune arthritis mice. Methods on joint diseases were assessed by clinical scoring histologic analysis. Protein expression levels confirmed immunohistochemistry, enzyme‐linked immunosorbent assay, flow cytometry, and/or Western blotting. messenger RNA (mRNA) for various molecules determined real‐time polymerase...
Most thoracolumbar fractures have a good healing outcome with adequate treatment. However, posttraumatic kyphosis can occur in proportion of after inappropriate treatment, osteoporosis, or osteonecrosis the vertebral body. There are several surgical options to correct kyphosis, including anterior, posterior, and combined approaches, which associated varying degrees success. The aim this study was assess use modified closing wedge osteotomy for treatment evaluate radiographic findings...
This exploratory, qualitative research explored the ethical problems faced by hospital social workers in South Korea and Australia, what who influenced their decision making using a focus group design. Although dilemmas of boundaries, confidentiality, self-determination, other complex scenarios found practice were identified, moral distress, consequence unresolvable conflicts, dominated participants' narratives. was particularly case for Korean this sample. A thematic analysis data yielded...
Hepatic artery thrombosis (HAT) is a common cause of graft loss in living-donor liver transplantation, occurring ~2.5%–8% patients. Some right lobe grafts have 2 hepatic arteries (HAs), and the optimal reconstruction technique remains controversial. This study aimed to identify risk factors for HAT evaluate efficacy reconstructing HAs grafts. retrospective, single-center analyzed 1601 transplantation recipients with divided them into 1 HA (n = 1524) 77) groups. The all was performed using...
Spirometry is used to evaluate postoperative outcomes in thoracic surgery. However, the clinical utility of spirometry for predicting complications has not been determined. We big-data analysis examine relationship between pulmonary function tests and complications.We retrospectively analysed data from 31,827 patients who underwent within 3 months prior their surgery January 2000 December 2014 at a single tertiary referral hospital. The were extracted de-identified form via automated...
The aim of this study was to determine the possible predictors primary arteriovenous fistula (AVF) failure and examine impact a preoperative evaluation on AVF outcomes.A total 539 patients who underwent assessment for suitable site creation by physical examination alone or additional duplex ultrasound were included in study. Demographics, patient characteristics, outcomes analyzed retrospectively.AVF proposed 469 (87.0%) according (351 patients) (118 patients); prosthetic graft initially...
The purpose of the study was to investigate effect an increase in sprinting velocity on anterior cruciate ligament (ACL) load, knee joint and activation femoral muscles using musculoskeletal modeling approach. Fourteen high school male athletes were recruited (age: 17.4 ± 0.7 years, height: 1.75 0.04 m, weight: 73.3 8.94 kg), with right foot dominant physical activity level about 3-4 h per day. kinematics, kinetics, co-contraction index (CCI) extensors flexors leg's calculated. load...