A5047450352- Chemical Synthesis and Reactions
- Oxidative Organic Chemistry Reactions
- Organic Chemistry Cycloaddition Reactions
- Synthesis and Biological Evaluation
- Synthesis and Reactions of Organic Compounds
- Microtubule and mitosis dynamics
- Asymmetric Synthesis and Catalysis
- Ubiquitin and proteasome pathways
- Synthesis of heterocyclic compounds
- Chemical Synthesis and Analysis
- Synthesis and Characterization of Heterocyclic Compounds
- Antimicrobial Peptides and Activities
- Vanadium and Halogenation Chemistry
- Synthesis and Catalytic Reactions
- Synthesis and biological activity
- Cancer-related Molecular Pathways
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Inorganic and Organometallic Chemistry
- Medical Imaging Techniques and Applications
- Computational Drug Discovery Methods
- Fluorine in Organic Chemistry
- Glycosylation and Glycoproteins Research
- RNA Interference and Gene Delivery
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Peptidase Inhibition and Analysis
Seoul National University
1991-2025
Korea University
2024
Maria Fertility Hospital
2024
Korea Basic Science Institute
2010-2023
Korea University of Science and Technology
2016-2023
Chungbuk National University
2014
Kongju National University
2011
Komatsu (Japan)
2008
Stanford University
2007-2008
National Institute of Environmental Health Sciences
2008
Alzheimer's disease (AD) is pathologically characterized by the accumulation of amyloid plaques and neurofibrillary tangles in brain, thus, vivo imaging would be beneficial for early diagnosis AD. It has been suggested that 5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,4,6-heptatrien-3-one (curcumin) may responsible low age-adjusted prevalence AD India. In present study, eight novel derivatives curcumin 4-(4-hydroxy-3-methoxyphenyl)-3-buten-2-one (dehydrozingerone) were synthesized their...
A simple modification of the Dittmer-Lester reagent is described that allows detection phospholipid derivatives at very low concentrations on silica gel and reversed-phase thin-layer plates.This modification, which involves addition acetic acid to mixture, permits observation sharp blue spots a white background.The specificity sensitivity spray are discussed.-Ryu,E. K., M. MacCoss.Modification for chromatograms.J .Lipid Res.
Both bombesin (BBN) analogs and cyclic RGD peptides have been suitably radiolabeled for prostate cancer imaging. However, the limited expression of gastrin-releasing peptide receptor (GRPR) integrin α<sub>v</sub>β<sub>3</sub> as well unfavorable in vivo kinetics further applications these imaging agents. We hypothesize that a ligand recognizing both GRPR will be advantageous because its dual-receptor–targeting ability. <b>Methods:</b> A BBN-RGD heterodimer was synthesized from bombesin(7–14)...
Background The conventional Work Triangle principle has long been a guiding concept in kitchen design, aiming to optimize workflow and minimize workload. However, with the advent of modern appliances evolving lifestyles, effectiveness addressing diverse activities needs contemporary kitchens is increasingly limited. Objective This study aims verify validity design propose modeling algorithm that facilitates customization based on layout area size from user-centered perspective. Methods...
Cep57 has been characterized as a component of pericentriolar complex containing Cep63 and Cep152. Interestingly, Cep152 self-assemble into cylindrical architecture, this event is critical for the orderly recruitment Plk4, key regulator centriole duplication. However, way in which interacts with Cep63-Cep152 contributes to structure function self-assembly remains unknown. We demonstrate that through N-terminal motifs associates via Cep63. Three-dimensional structured illumination microscopy...
Micelles for mucosal immunity: A vaccine system based on γ-PGA nanomicelles and viral antigens was synthesized. The intranasal administration of the induces a high immune response both in humoral cellular immunity (see picture). As service to our authors readers, this journal provides supporting information supplied by authors. Such materials are peer reviewed may be re-organized online delivery, but not copy-edited or typeset. Technical support issues arising from (other than missing files)...
Polo-like kinase 1 (PLK1), which is crucial in cell cycle regulation, considered a promising anticancer drug target. Herein, we present the N-degron pathway-based proteolysis targeting chimera (PROTAC) for PLK1 degradation, Polo-box domain (PBD). We identified DD-2 as most potent PROTAC that selectively induces degradation cancer cells, including HeLa and nonsmall lung (NSCLC), through pathway. exhibited significant vitro effects, inducing G2/M arrest apoptosis NSCLC lines. showed tumor...
Chan-Mi Park, Hye-Min Kim, Dong Hyun Ho-Jin Han, Haneul Noh, Jae-Hyuk Jang, Soo-Hyun Han-Jung Chae, Soo-Wan Eun Kyoung Ryu, Sangku Lee, Kangdong Liu, Haidan Jong-Seog Ahn, Young Ock Bo-Yeon and Nak-Kyun Soung. Mol. Cells 2016;39:855-61. https://doi.org/10.14348/molcells.2016.0111
Polo-like kinase-1 (Plk1) plays a key role in mitosis and has been identified as an attractive anticancer drug target. Plk1 consists of two drug-targeting sites, namely, N-terminal kinase domain (KD) C-terminal polo-box (PBD). As KD-targeting inhibitors are associated with severe side effects, here we report on the pyrazole-based PBD inhibitor, KBJK557, which showed remarkable vitro effect by inducing delocalization, mitotic arrest, apoptosis HeLa cells. Further, vivo optical imaging...
Abstract Considering the emergence of bacterial resistance and low proteolytic stability antimicrobial peptides (AMPs), herein we developed a series ultra-short triazine based amphipathic polymers (TZP) that are connected with ethylene diamine linkers instead protease sensitive amide bond. The most potent oligomers, TZP3 TZP5 not only displayed antibacterial action on various drug-resistant pathogens but also exhibited strong synergic activity in combination chloramphenicol against...
To combat the escalating rise of antibacterial resistance, development antimicrobial peptides (AMPs) with a unique mode action is considered an attractive strategy. However, proteolytic degradation AMPs remains greatest challenge in their transformation into therapeutics. Herein, we synthesized Fmoc-triazine amino acids that differ from each other by anchoring either cationic or hydrophobic residues. These unnatural were adopted for solid-phase peptide synthesis (SPPS) to synthesize series...
Gold nanoparticles (AuNPs) have been widely used as nanocarriers in drug delivery to improve the efficiency of chemotherapy treatment and enhance early disease detection. The advantages AuNPs include their excellent biocompatibility, easy modification functionalization, facile synthesis, low toxicity, controllable particle size. This study aimed synthesize a conjugated citraconic anhydride link between morphologically homogeneous doxorubicin (DOX) (DOX-AuNP). carrier was radiolabeled for...