A5015405711- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Cancer Genomics and Diagnostics
- Colorectal Cancer Screening and Detection
- Colorectal Cancer Surgical Treatments
- Pancreatic and Hepatic Oncology Research
- Colorectal and Anal Carcinomas
- Cancer-related Molecular Pathways
- Gastric Cancer Management and Outcomes
- DNA Repair Mechanisms
- Epigenetics and DNA Methylation
- Advances in Oncology and Radiotherapy
- Global Cancer Incidence and Screening
- Neuroendocrine Tumor Research Advances
- Effects of Radiation Exposure
- DNA and Nucleic Acid Chemistry
- Esophageal Cancer Research and Treatment
- Lung Cancer Diagnosis and Treatment
- Cancer Cells and Metastasis
- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Prostate Cancer Diagnosis and Treatment
- RNA Interference and Gene Delivery
- Adenosine and Purinergic Signaling
- Virus-based gene therapy research
The Alfred Hospital
2020-2024
Alfred Health
2020-2024
Monash University
2020-2022
Australian National University
2008-2020
Canberra Hospital
2007-2020
Australian Cancer Research Foundation
2020
ACT Government
2007-2020
Creative Commons
2016
Yale Cancer Center
2016
NRG Oncology
2016
For patients with locally advanced rectal cancer (LARC), adjuvant chemotherapy selection following surgery remains a major clinical dilemma. Here, we investigated the ability of circulating tumour DNA (ctDNA) to improve risk stratification in LARC.We enrolled LARC (T3/T4 and/or N+) planned for neoadjuvant chemoradiotherapy. Plasma samples were collected pretreatment, postchemoradiotherapy and 4-10 weeks after surgery. Somatic mutations individual patient's identified via massively parallel...
High levels of thymidylate synthase (TS) expression have been associated with poor survival colorectal cancer (CRC) patients to 5-fluorouracil (5-FU)-based chemotherapy. Recent evidence suggests that a polymorphism within the enhancer region TS gene promoter can influence expression, triple repeat homozygote (3R/3R) being significantly higher tumour than either double (2R/2R) or heterozygotes (2R/3R). In present study we investigated whether genotype was degree benefit from chemotherapy in...
Two common genetic alterations in colon carcinoma, p53 mutation and microsatellite instability (MSI), were investigated to determine their prognostic importance for cancer-specific survival response adjuvant chemotherapy patients with Dukes' C cancer. The tumour suppressor gene encodes a nuclear phosphoprotein involved cellular DNA damage, while MSI is characteristic feature of tumours defective mismatch repair. mechanisms DNA-damaging agents mutant or may as consequence differ, this might...
The DNA damage response (DDR) activates downstream pathways including cell cycle checkpoints. cyclin D1 gene is overexpressed or amplified in many human cancers and required for gastrointestinal, breast, skin tumors murine models. A common polymorphism the alternatively spliced, resulting D1a D1b proteins that differ their carboxyl terminus. Cyclin overexpression enhances damage-induced apoptosis. role of alternative splice form regulating DDR not well understood. Herein enhanced as...
The predominant mode of radiation-induced cell death for solid tumours is mitotic catastrophe, which in part dependent on sublethal damage repair being complete at around 6 h. Circadian variation appears to play a role normal cellular division, and this could influence tumour response radiation treatment depending the time delivery. We tested hypothesis that later day may improve nodal downstaging rectal cancer patients treated neoadjuvantly with therapy. Recruitment was by retrospective...
<i>Objectives: </i>The survival of stage II colorectal cancer (CRC) patients is approximately 70% at 5 years. Identification the patient subgroup high risk for tumour recurrence and death would allow more informed use chemotherapy this disease. Several clinical pathological factors have been reported to associate with worse survival. In present study we investigated prognostic significance two major genetic alterations in CRC: microsatellite instability (MSI+) type...
The aim of this study was to investigate the value cyclin D1 isoforms D1a and D1b as prognostic factors their relevance predictors response adjuvant chemotherapy with 5-fluorouracil levamisole (5-FU/LEV) in colorectal cancer (CRC). Protein expression nuclear assessed by immunohistochemistry 335 CRC patients treated surgery alone or therapy using 5-FU/LEV. predictive these two molecular markers clinicopathological were evaluated statistically univariate multivariate survival analyses. Neither...
Abstract Ki‐ ras mutations are associated with an increased risk of relapse and death in colorectal cancer (CRC) patients, some being more aggressive than others. The present study examined the predictive value different mutation types a retrospective series 430 Dukes' C stage CRC whom 208 (48%) had received adjuvant chemotherapy 5‐fluorouracil/levamisole or 5‐fluorouracil/leucovorin. A total 140 were detected, majority (58%, 81/140) glycine to aspartate codons 12 13. Glycine valine codon...
Background/Aim: Endoscopic submucosal dissection (ESD) followed by chemoradiotherapy (CRT) has become a promising treatment modality in the management of early-stage superficial esophageal squamous cell carcinoma (SESCC). However, radiotherapy often leads to significant adverse events (AEs), including cardiopulmonary toxicity, limiting delivery this modality. This study aimed evaluate efficacy reduced-volume and dose-dense chemotherapy mitigating AEs for high-risk SESCC following ESD....
3521 Background: The optimal approach to adjuvant chemotherapy for rectal cancer is keenly debated. Routine practice and clinical guidelines vary widely. After pre-operative chemoradiation (CRT), a pathologic complete response (pCR) or nodal involvement (pN+) are prognostic markers that can guide decision-making, but better define the patients (pts) likely unlikely benefit from urgently needed. We investigated potential role of ctDNA as biomarker therapy. Methods: conducted prospective,...