A5044159056- Cancer-related Molecular Pathways
- Breast Cancer Treatment Studies
- Cancer Genomics and Diagnostics
- Esophageal Cancer Research and Treatment
- Lung Cancer Treatments and Mutations
- Breast Lesions and Carcinomas
- Pancreatic and Hepatic Oncology Research
- HER2/EGFR in Cancer Research
- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Cancer Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Cancer, Hypoxia, and Metabolism
- Medical Imaging and Pathology Studies
- RNA modifications and cancer
- Colorectal and Anal Carcinomas
- Colorectal Cancer Surgical Treatments
- Cancer Treatment and Pharmacology
- Hepatocellular Carcinoma Treatment and Prognosis
- Fibroblast Growth Factor Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Monoclonal and Polyclonal Antibodies Research
- Kruppel-like factors research
- Epigenetics and DNA Methylation
- Lung Cancer Diagnosis and Treatment
Medical University of Vienna
2007-2018
Comprehensive Cancer Center Vienna
2018
Vienna General Hospital
2001-2013
Universitätsklinik für Chirurgie Wien
1993-2009
Fachhochschule Wiener Neustadt
2009
University of Vienna
1994-2007
University of Palermo
2006
Ruhrlandklinik
2005
Essen University Hospital
2005
The standardized Clavien-Dindo classification of surgical complications is applied as a simple and widely used tool to assess report postoperative in general surgery. However, most documentation uses this surgery-related morbidity mortality single field surgery or even particular intervention. aim the present study was experiences with when all patients on ward tertiary referral care center.We analyzed period 6 months broad range visceral Discharge reports patient charts were retrospectively...
Abstract Fibroblast growth factors (FGFs) and their high-affinity receptors [fibroblast factor (FGFRs)] contribute to autocrine paracrine stimulation in several nonliver cancer entities. Here we report that at least one member of the FGF8 subfamily (FGF8, FGF17, FGF18) was up-regulated 59% 34 human hepatocellular carcinoma (HCC) samples investigated. The levels corresponding (FGFR2, FGFR3, FGFR4) were also elevated great majority HCC cases. Overall, 82% cases showed overexpression FGF and/or...
Abstract BACKGROUND HER‐2/ neu is a valuable prognostic marker in primary breast carcinoma. Controversy surrounds the correlation between expression and other markers, as has been discussed preclinical clinical studies. The objective of current study was to investigate probability, calculated using parameters that are assessed routinely practice, patients with carcinoma had positive status. METHODS authors evaluated status 923 consecutive by immunohistochemical methods. Correlations...
To evaluate and compare the predictive power of p53 gene analysis versus immunohistochemical staining in terms response to preoperative short-term radiotherapy using 25 Gy operable rectal cancer.Recent studies show that may be a determinant radiosensitivity being required for induction apoptosis case radiation-induced DNA damage.Preirradiation biopsy samples 64 patients with carcinoma were analyzed. Genetic alterations detected by complete direct sequencing exons 2 10. Expression nuclear...
The objective of this analysis was to determine the accuracy steroid receptor measurement in large core needle biopsies compared with surgically removed specimens and influence preoperative chemotherapy on hormone status. We consecutively performed 722 palpable lesions breast. diagnosis breast cancer confirmed upon biopsy 450 patients; 236 women underwent immediate surgery, 214 patients received chemotherapy. assessed estrogen (ER) progesterone (PR) tissue calculated accuracy, sensitivity,...
We investigated the hypothesis that varying treatment efficacy of adjuvant 5-fluorouracil (5FU) in stage III colon cancer is linked to TP53 mutational status. ABCSG-90 was a prospective randomized trial which effect 5FU studied patients. Tumor material 70% these patients (389/572) available for analysis biomarker using TP53-gene-specific Sanger sequencing protocol. Median follow-up 88 months. mutation frequency 33%. A significant interaction between status, outcomes and nodal category found...
Fibroblast growth factor receptors (FGFRs) are frequently up‐regulated in subsets of hepatocellular carcinoma (HCC). Here, we provide mechanistic insight that FGFR3 splice variants IIIb and IIIc impact considerably on the malignant phenotype HCC cells. The occurrence was analyzed human samples. In hepatoma/hepatocarcinoma cell lines, isoforms were overexpressed by lentiviral constructs or down‐modulated small interfering RNA (siRNA; affecting FGFR3‐IIIb ‐IIIc) an adenoviral kinase‐dead...
Change of DNA cytosine methylation (5mC) is an early event in the development cancer, and recent discovery a 5-hydroxymethylated form (5hmC) suggests regulatory epigenetic role that might be different from 5-methylcytosine. Here, we aimed at elucidating 5hmC breast cancer. To interrogate levels leucine zipper, putative tumor suppressor 1 (LZTS1) gene detail, analyzed 75 primary cancer tissue samples initial diagnosis 12 normal derived healthy persons. Samples were subjected to...
Background. Liver transplantation for nonresectable liver metastases from colorectal cancer was abandoned in 1994 on account of high recurrence rates. The aim this study to investigate whether the genetic detection micrometastases histologically negative lymph nodes primary colon could be applied select patients transplantation. Methods. We analyzed 21 with who had undergone between 1983 and metastases. Eleven were node at time surgery; ten served as control group. DNA sequencing used screen...
To enable detailed analyses of cell interactions in tumour development, new epithelial and mesenchymal lines were established from human hepatocellular carcinoma by spontaneous outgrowth culture. We obtained several hepatocarcinoma (HCC)-, B-lymphoblastoid (BLC)-, myofibroblastoid (MF)-lines seven cases. In-depth characterisation included kinetics, genotype, tumourigenicity, expression cell-type specific markers, proteome patterns. Many functions the cells origin found to be preserved....