A5069294662- Genetic and phenotypic traits in livestock
- Cancer-related molecular mechanisms research
- Genetic Mapping and Diversity in Plants and Animals
- Hair Growth and Disorders
- Reproductive Biology and Fertility
- Reproductive Physiology in Livestock
- Growth Hormone and Insulin-like Growth Factors
- Muscle Physiology and Disorders
- RNA Research and Splicing
- Genetics, Aging, and Longevity in Model Organisms
- Bone Metabolism and Diseases
- Animal Genetics and Reproduction
- Neuroendocrine Tumor Research Advances
- Skin and Cellular Biology Research
- Fibroblast Growth Factor Research
- Medical Imaging and Analysis
- Genomic variations and chromosomal abnormalities
- Rangeland Management and Livestock Ecology
- Ruminant Nutrition and Digestive Physiology
- Veterinary Equine Medical Research
- Cancer and Skin Lesions
- Kruppel-like factors research
- Livestock Farming and Management
- Osteoarthritis Treatment and Mechanisms
Xinjiang Institute of Ecology and Geography
2020-2024
Chinese Academy of Sciences
2020-2024
University of Chinese Academy of Sciences
2020-2024
This study aimed to elucidate the underlying gene regions responsible for productive, phenotypic or adaptive traits in different ecological types of Tibetan sheep and discovery important genes encoding valuable traits.We used whole-genome resequencing explore genetic relationships, phylogenetic tree, population structure analysis. In addition, we identified 28 representative single-nucleotide polymorphisms (SNPs) genomic selective sweep with by fixation index (Fst) nucleotide diversity (θπ)...
Abstract Domestication and artificial selection during production-oriented breeding have greatly shaped the level of genomic variability in sheep. However, genetic variation associated with increased reproduction remains elusive. Here, two groups samples from consecutively monotocous polytocous sheep were collected for genome-wide association, transcriptomic, proteomic, metabolomic analyses to explore fecundity Tibetan Genome-wide association study revealed strong associations between BMPR1B...
Abstract Background The Qinghai Tibetan sheep, a local breed renowned for its long hair, has experienced significant deterioration in wool characteristics due to the absence of systematic breeding practices. Therefore, it is imperative investigate molecular mechanisms underlying follicle development order genetically enhance wool-related traits and safeguard sustainable utilization valuable germplasm resources. However, our understanding regulatory roles played by coding non-coding RNAs hair...
The identification of candidate genes and genetic variations associated with growth traits is important for sheep breeding. Insulin like factor 1 (IGF1) insulin receptor (IGF1R) are well-accepted that affect animal development. current study attempted to assess the association between IGF1 IGF1R polymorphisms in Hulun Buir sheep. To achieve this goal, we first identified three ten single nucleotide (SNPs) exons then constructed six haplotypes based on linkage disequilibrium, respectively....
Abstract Introduction Tibetan sheep, economically important animals on the Qinghai–Tibet Plateau, have diversified into numerous local breeds with unique characteristics through prolonged environmental adaptation and selective breeding. However, most current research focuses one or two breeds, lacks a comprehensive representation of genetic diversity across multiple sheep breeds. This study aims to fill this gap by investigating structure, high-altitude 6 using whole-genome resequencing...
Abstract Background Elucidating the genetic variation underlying phenotypic diversity will facilitate improving production performance in livestock species. The Tibetan sheep breed China holds significant historical importance, serving as a fundamental pillar of Qinghai’s animal husbandry sector. Plateau-type sheep, comprising 90% province’s population, are characterized by their tall stature and serve primary among sheep. In contrast, Zhashijia exhibit larger size superior meat quality....
Tibetan sheep are vital to the ecosystem and livelihood of Plateau; however, traditional breeding methods limit their production growth. Modern molecular techniques required improve these traits. This study identified a single nucleotide polymorphism (SNP) in myostatin (MSTN) Callipyge sheep. The findings indicated notable associations between MSTN genotypes growth traits including birth weight (BW), body length (BL), chest width (ChW), circumference (ChC), as well particularly strong...
The types and morphology of sheep horns have been extensively researched, yet the genetic foundation underlying emergence diverse horn characteristics during breeding polled Tibetan has remained elusive. Genome-wide association analysis (GWAS) was performed on 103 subtypes (normal large horn, scurs, polled) differentiated from G2 (offspring (G2) parent (G1) core herd. Six single nucleotide polymorphisms (SNPs) located chromosome 10 relaxin family peptide receptor 2 (RXFP2) gene exhibited...
Long hair trait represents a valuable genetic asset in Qinghai Tibetan sheep, with its quality and yield being contingent upon the characteristics of follicles (HFs). This study aims to elucidate mechanism underlying primary (PFs) formation through an integrated analysis proteomics transcriptomics. Samples were collected at key stages fetal HF (E65 E85) for histological observation, revealing significant alterations microstructure PF (E65) during developmental process. In this study,...
This study was conducted to evaluate SSTR1 gene polymorphisms and their association with growth traits in Hulun Buir sheep. We followed 233 sheep from birth 16 months of age, born the same pasture on year under a consistent grazing conditions. The body weight (BW), height (BH), length (BL), chest circumference (ChC), depth (ChD), width (ChW), hip (HW), cannon (CaC) were measured recorded at birth, 4 months, 9 age. excavated using exon sequencing, analyses between SNPs each stage conducted....
Qinghai fine-wool sheep is a Chinese domestic breed developed by complex crossing. We established stable genetic core population of twin lambs through artificial intervention. However, few studies have been done on the fecundity breeding varieties, probably because long-term nature and complexity work. Selection signatures associated with reproductive traits were identified whole-genome sequencing ewes litter size differences to select candidate genes related increase in this breed. Several...
Qaidam Cashmere goat is one of the few animals that can survive in harsh environment Qinghai-Tibet Plateau and adjacent alpine areas.It has a strong adaptability, thus shaping genetic diversity phenotype, morphology, physiology other aspects.However, molecular basis behind these mechanisms remains unclear.Here, we conducted genome-wide studies variation two different morphologies geographical coordinates indigenous Chinese goats to identify selective signaling genomic regions.In present...
The aim of this study was to locate SSTR5 polymorphisms and evaluate their association with growth traits in Hulun Buir sheep. followed up 884 sheep from birth 16 months age, which were born the same pasture year, a consistent grazing management strategy maintained. weight (BRW) recorded at birth, body (BW), height (BH), length (BL), chest circumference (ChC), depth (ChD), width (ChW), hip (HW), cannon (CaC) measured 4 9 age. BW, BH, BL, ChD, HW, CaC also Based on traits, 233 selected as...
Abstract Copy number variation (CNV) is a genetic structural polymorphism important for phenotypic diversity and economic traits of livestock breeds, it plays an role in the desired variation. This study used whole genome sequencing to detect CNV 6 local Tibetan sheep groups. We detected 69,166 events 7230 copy variable regions (CNVRs) after merging overlapping CNVs, accounting 2.72% reference genome. The CNVR length ranged from 1.1 1693.5 Kb, with total 118.69 Mb average 16.42 Kb per CNVR....
Abstract Background: Environmental conditions and extensive rearing impose a myriad of selective pressures on domesticated animals living at high altitude. These have selected for the characteristics strong adaptability life in alpine pastoral area. While it is accepted that various natural anthropogenic factors, such as environmental pressures, human migration, socioeconomic practices, shaped genomic structure goats, little known regarding resulting genetic adaptations. The goat (Capra...