Bioinspired multicompartmental microfibers are generated by novel capillary microfluidics. The resultant possess multicompartment body-and-shell compositions with specifically designed geometries. Potential use of these for tissue-engineering applications is demonstrated creating multifunctional fibers a spatially controlled encapsulation cells.

We report a facile approach to encapsulating amoxicillin (AMX) within laponite (LAP)-doped poly(lactic-co-glycolic acid) (PLGA) nanofibers for biomedical applications. In this study, synthetic clay material, LAP nanodisks, was first used encapsulate AMX. Then, the AMX-loaded nanodisks with an optimized AMX loading efficiency of 9.76 ± 0.57% were incorporated PLGA through electrospinning form hybrid PLGA/LAP/AMX nanofibers. The and LAP/AMX characterized via different techniques. vitro drug...

Aptamer-functionalized barcode particles are employed to capture and detect various types of circulating tumor cells (CTCs). The spherical colloidal crystal clusters, the reflection properties that arise from their structures how codes evaluated. Aptamer functionalization (with TD05, Sgc8, Sgd5) make interact with specific CTC types; dendrimers used amplify effect aptamers, allowing for increased sensitivity, reliability, specificity in capture, detection, subsequent release. As a service...

Electrospun composite nanofibrous scaffolds have attracted much interest for use as drug delivery vehicles in recent years. Herein, we attempted to first encapsulate the anticancer doxorubicin (DOX) using inorganic rod-like nano-hydroxyapatite (n-HA) a carrier. Then, DOX-loaded n-HA particles were mixed with poly(lactic-co-glycolic acid) (PLGA) solution fabricate electrospun hybrid nanofibers. The formation of drug–n-HA complexes and drug-loaded nanofibers characterized different techniques....

The development of effective drug screening platforms is an important task for biomedical engineering. Here, a novel methacrylated gelatin (GelMA) hydrogel-encapsulated core-shell photonic crystal (PhC) barcode particle was developed three-dimensional cell aggregation culture and screening. GelMA shells the particles enable creation extracellular matrix (ECM) microenvironment adhesion growth, while PhC cores provide stable diffraction peaks that can encode different spheroids during...

Significance Microfluidics is an important in vitro platform to gain insights into mechanics of blood flow and mechanisms pathophysiology human diseases. Extraction 3D fields microfluidics with dense cell suspensions remains a formidable challenge. We present artificial-intelligence velocimetry (AIV) as general determine microaneurysm-on-a-chip simulate microaneurysms patients diabetic retinopathy. AIV built on physics-informed neural networks that integrate seamlessly 2D images from...

The spleen clears altered red blood cells (RBCs) from circulation, contributing to the balance between RBC formation (erythropoiesis) and removal. splenic retention elimination occur predominantly in open circulation where RBCs flow through macrophages inter-endothelial slits (IESs). mechanisms underlying interconnecting these processes significantly impact clinical outcomes. In sickle cell disease (SCD), blockage of intrasplenic sickled is observed infants splenectomized due acute...

Abstract In this article, we report the surface modification of branched polyethyleneimine (PEI) for improved biocompatibility. PEIs with different functionalities were synthesized via covalent PEI amines, including neutralized modified acetic anhydride, negatively charged succinic hydroxylated glycidol, and PEI–poly(ethylene glycol) (PEG) conjugates both PEG anhydride. The derivatives characterized 1 H‐NMR, Fourier transform infrared spectroscopy, ζ‐potential measurements. An in vitro...

Photonic crystal encoded biomaterials microcarriers made from silica-hybrid photonic beads are reported. The characteristic reflection peak originating the physical periodic structure is used as code of microcarriers. They stable during cell adhesion and culture on their surface. Based this method, Different incorporated into different PCBs for multiplex evaluation interaction cells materials in a single experiment. These ideal bioevaluation or drug applications.

Three-dimensional (3D) extrusion-based bioprinting is the most widely used technology to fabricate bionic tissue or organ constructs by combining biomaterial ink and living cells for engineering regenerative medicine. One critical issue of this technique selection suitable simulate extracellular matrix (ECM) that provides mechanical support regulates their physiological activities. Previous studies have demonstrated it an enormous challenge form maintain reproducible 3D eventually achieve...

A circlular structural-colored contact lens is reported, which fabricated by replicating self-assembled colloidal photonic crystal templates. The lenses not only display variable and brilliant color under light illumination, but also avoid the addition of any colorants to hydrogel prevent potential harm posed traditional colored lenses.

A new type of structural color paint was fabricated by dispersing poly(methyl methacrylate-hydroxyethyl methacrylate) (PMH) nanoparticles in 2-hydroxyethyl methacrylate (HEMA) solvent without additional surfactants. The paints then were directly cast to form contact lenses UV polymerization moulds.

Hybrid inverse opal substrates with tunable patterned nanostructures were developed for regulating the cell behaviors of adhesion and alignment.

REMA is a more reliable and accurate approach for cytocompatibility evaluation of nanofibrous materials than MTT assay.

In recent years, multiple types of substrates have been applied for regulating cell orientation. Among them, surface topography patterns with grooves or ridges widely utilizing culturing. However, this construction is still complicated, low cost-effective and exhibits some technological limitations either "top-down" "bottom-up" approaches. Here, a simple green method was developed by butterfly wings (Morpho menelaus, Papilio ulysses telegonus Ornithoptera croesus lydius) natural anisotropic...

CsPbX3 (X = Cl, Br, and I) perovskite nanocrystals (NCs) are known for their exceptional optoelectronic properties, yet the material's instability toward polar solvents, heat, or UV irradiation greatly limits its further applications. Herein, an efficient in situ growing strategy has been developed to give highly stable NC composites (abbreviated CsPbX3@CA-SiO2) by anchoring NCs onto silica nanowires (NWs), which effectively depresses optical degradation of photoluminescence (PL) enhances...

Photonic crystal (PC) barcodes are a new type of spectrum-encoding microcarriers used in multiplex high-throughput bioassays, such as broad analysis biomarkers for clinical diagnosis, gene expression, and cell culture. Unfortunately, most these existing PC suffered from undesired features, including difficult spectrum-signal acquisition, weak mechanical strength, high ontology fluorescence, which limited their development to real applications. To address limitations, we report structural...