A5091714768- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Impact on Reproduction
- Pulmonary Hypertension Research and Treatments
- Neonatal Respiratory Health Research
- COVID-19 and Mental Health
- Airway Management and Intubation Techniques
- SARS-CoV-2 detection and testing
- Long-Term Effects of COVID-19
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Dialysis and Renal Disease Management
- Cardiac Structural Anomalies and Repair
- COVID-19 epidemiological studies
- Voice and Speech Disorders
- Trauma Management and Diagnosis
- Dysphagia Assessment and Management
- Complement system in diseases
- Neuroscience of respiration and sleep
- Adenosine and Purinergic Signaling
- Congenital Diaphragmatic Hernia Studies
- Blood donation and transfusion practices
- Ion Channels and Receptors
- Electroconvulsive Therapy Studies
- Psychiatric care and mental health services
- Urticaria and Related Conditions
University of Wisconsin–Madison
2020-2022
Icahn School of Medicine at Mount Sinai
2021
Mayo Clinic
2010-2015
Mayo Clinic in Florida
2014
SUNY Downstate Health Sciences University
2013
WinnMed
2012-2013
Rosalind Franklin University of Medicine and Science
2004-2007
University of Louisville
1998
Straub Medical Center
1986
Abstract To determine the effect of COVID-19 convalescent plasma on mortality, we aggregated patient outcome data from randomized clinical trials, matched control, case series, and report studies. Fixed-effects analyses demonstrated that hospitalized patients transfused with exhibited a ~57% reduction in mortality rate (10%) compared to matched-patients receiving standard treatments (22%; OR: 0.43, P < 0.001). These provide evidence favouring efficacy human as therapeutic agent patients.
Maintenance of blood oxygen saturation dictates supplemental administration to premature infants, but hyperoxia predisposes survivors respiratory diseases such as asthma. Although much research has focused on effects alveoli in the setting bronchopulmonary dysplasia, mechanisms by which affects airway structure or function relevant asthma are still under investigation. We used isolated human fetal smooth muscle (fASM) cells from 18–20 postconceptual age lungs (canalicular stage) examine...
Neurotrophins (NTs), which play an integral role in neuronal development and function, have been found non-neuronal tissue (including lung), but their is still under investigation. Recent reports show that NTs such as brain-derived neurotrophic factor (BDNF) well NT receptors are expressed human airway smooth muscle (ASM). However, function We hypothesized regulate ASM intracellular Ca2+ ([Ca2+]i) by altered expression of regulatory proteins. Human cells isolated from lung samples incidental...
SARS-CoV-2 and its associated disease, COVID-19, has infected over seven million people world-wide, including two in the United States. While many recover from virus uneventfully, a subset of patients will require hospital admission, some with intensive care needs intubation, mechanical ventilation. To date there is no cure vaccine available. Passive immunotherapy by transfusion convalescent plasma donated COVID-19 recovered might be an effective option to combat virus, especially if used...
Abstract Introduction The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), is responsible for a worldwide pandemic. While the medical community understands mode of viral transmission, less known about how long shedding occurs once symptoms have resolved. Our objective was to determine SARS‐CoV‐2 remains detectable following self‐reporting symptom resolution. Methods This study approved by University Wisconsin Institutional Review Board. A cohort patients who...
The nasal mucosa is an important initial site of host defense against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, intramuscularly administered vaccines typically do not achieve high antibody titers in the mucosa. We measure anti-SARS-CoV-2 spike immunoglobulin G (IgG) and IgA epithelial lining fluid (NELF) following intramuscular vaccination 3,058 participants from immunogenicity substudy a phase 3, double-blind, placebo-controlled study AZD1222...
SARS-CoV-2 and its associated disease, COVID-19, has infected over seven million people world-wide, including two in the United States. While many recover from virus uneventfully, a subset of patients will require hospital admission, some with intensive care needs intubation, mechanical ventilation. To date there is no cure vaccine available. Passive immunotherapy by transfusion convalescent plasma donated COVID-19 recovered might be an effective option to combat virus, especially if used...
The novel coronavirus, SARS-CoV-2 that causes COVID-19 has resulted in the death of nearly 4 million people within last 18 months. While preventive vaccination, and monoclonal antibody therapies have been rapidly developed deployed, early pandemic use convalescent plasma (CCP) was a common means passive immunization with theoretical risk antibody-dependent enhancement (ADE) viral infection. Though vaccines elicit strong protective immune response transfusion CCP high titers neutralization...
Background Hypoxia effects on pulmonary artery structure and function are key to diseases such as hypertension. Recent studies suggest that growth factors called neurotrophins, particularly brain-derived neurotrophic factor (BDNF), can influence lung function, their role in the warrants further investigation. In this study, we examined effect of hypoxia BDNF humans, hypoxia-enhanced expression signaling human smooth muscle cells (PASMCs). Methods Results 48h 1% enhanced TrkB expression, well...
The triallelic serotonin transporter gene linked polymorphic region (5-HTTLPR) has been associated with alterations in thermal pain perception. primary aim of this study was to investigate the associations between heat (HP) perception and 5-HTTLPR a large cohort adults chronic pain.The included 277 who met inclusion criteria, were consecutively admitted an outpatient rehabilitation program from March 2009 through 2010. Individuals genotyped for (including rs25531) categorized as high,...
0 Abstract In the absence of effective countermeasures, human convalescent plasma has been widely used to treat severe acute respiratory syndrome coronavirus 2 including among patients with innate or acquired immunodeficiency. However, association between COVID-19-associated mortality in immunodeficiency and therapeutic use is unknown. We review clinical features treatment protocols COVID-19 after plasma. also discuss time course recovery. These insights provide evidence for need develop a...
CD38 is an ecto-enzyme that hydrolyzes NAD. Its expression a prognostic marker for chronic lymphocytic leukemia. We have characterized individual variation in lymphoblastoid cell lines from 288 healthy subjects of three ethnicities. Expression varied widely, with significant differences among ethnic groups, and was correlated significantly enzymatic activity protein levels. The gene then resequenced using DNA the same lines, identification 53 single nucleotide polymorphisms (SNPs) one indel,...
The nucleoside analog 2-chloro-2'-deoxyadenosine (CldAdo; cladribine) is effective in the treatment of hairy cell leukemia and chronic lymphocytic leukemia. CldAdo phosphorylated incorporated into cellular DNA but not an absolute chain terminator. We demonstrated by vitro gel-shift assays that binding interactions human TATA box-binding protein (TBP) were disrupted on 2-chlorodeoxyadenosine monophosphate (CldAMP)-substituted box consensus sequences. hypothesized RNA polymerase II (pol II)...
Tracheobronchial disruption is an uncommon but severe complication of double lumen endotracheal tube placement. The physical properties a (large external diameter and length) make tracheobronchial injury more common than that associated with smaller single tubes. Here we present the case iatrogenic left main bronchus caused by placement in otherwise unremarkable airway.
Abstract Background: SARS-CoV-2 and its associated disease, COVID-19, has infected over seven million people world-wide, including two in the United States. While many recover from virus uneventfully, a subset of patients will require hospital admission, some with intensive care needs intubation, mechanical ventilation. To date there is no cure vaccine available. Passive immunotherapy by transfusion convalescent plasma donated COVID-19 recovered might be an effective option to combat virus,...
Abstract Background SARS-CoV-2 and its associated disease, COVID-19, has infected over seven million people world-wide, including two in the United States. While many recover from virus uneventfully, a subset of patients will require hospital admission, some with intensive care needs intubation, mechanical ventilation. To date there is no cure vaccine available. Passive immunotherapy by transfusion convalescent plasma donated COVID-19 recovered might be an effective option to combat virus,...