A5019537124- Phosphodiesterase function and regulation
- Mast cells and histamine
- Receptor Mechanisms and Signaling
- Air Quality and Health Impacts
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Birth, Development, and Health
- Asthma and respiratory diseases
- Pharmacological Receptor Mechanisms and Effects
- Diet, Metabolism, and Disease
- Mercury impact and mitigation studies
- Pregnancy and preeclampsia studies
- Heavy Metal Exposure and Toxicity
- Geology and Environmental Impact Studies
- Liver Disease Diagnosis and Treatment
- Neuropeptides and Animal Physiology
- Integrated Water Resources Management
- Neurogenesis and neuroplasticity mechanisms
- Bee Products Chemical Analysis
- Pregnancy and Medication Impact
- Nerve injury and regeneration
- Cholinesterase and Neurodegenerative Diseases
- Glutathione Transferases and Polymorphisms
- Sustainable Development and Environmental Management
- Neural dynamics and brain function
Jagiellonian University
2011-2024
Collegium Medicum in Bydgoszcz
1997
Asthma is a heterogeneous, chronic respiratory disease characterized by airway inflammation and remodeling. Phosphodiesterase (PDE) inhibitors represent one of the intensively studied groups potential anti-asthmatic agents due to their affecting both However, effect inhaled pan-PDE on allergen induced asthma has not been reported date. In this study we investigated impact two, representative strong from group 7,8-disubstituted derivatives 1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione:...
Many studies involving compounds that enhance histamine release, such as H3 receptor (H3R) antagonists, have shown efficacy in inhibiting weight gain, but none passed clinical trials. As part of the search for ligands additional properties, aim this study is to evaluate activity reduction gain a rat model excessive eating, well impact on selected metabolic parameters, and number size adipocytes two new H3R KSK-60 KSK-74, which also exert significant affinity at sigma-2 receptor. Compounds...
Background: Numerous studies highlight the critical role that neural histamine plays in feeding behavior, which is controlled by central H3 and H1 receptors. This fundamental motivation for increased interest creating receptor antagonists as anti-obesity medications. On other hand, multiple neurotransmitter systems have been identified pharmacotherapeutic targets obesity, including sigma-2 systems. Interestingly, our previous rat excessive eating model, we demonstrated a significant...
Abstract Purpose This study aimed to assess the activity of two phosphodiesterase (PDE) inhibitors, namely GRMS-55 and racemic lisofylline ((±)-LSF)) in vitro animal models immune-mediated disorders. Methods Inhibition human recombinant (hr)PDEs TNF-alpha release from LPS-stimulated whole rat blood by studied compounds were assessed . LPS-induced endotoxemia, concanavalin A (ConA)-induced hepatitis, collagen-induced arthritis (CIA) used for vivo evaluation. The potency investigated was...
Background: Quinazoline α1-adrenoceptors antagonists have been shown to exert moderately favorable effects on the metabolic profile in hypertensive patients. However, based AntiHypertensive and Lipid-Lowering Treatment Prevent Heart Attack Trial (ALLHAT) results, they are no longer recommended as a first line therapy of hypertension. Recent studies that quinazoline-based (prazosin, doxazosin) induce apoptosis necrosis, which may be responsible for ALLHAT outcomes; however, these were proven...
Purpose: There is a strong medical demand to search for novel, more efficacious and safer than available, analgesics the treatment of neuropathic pain. This study investigated antinociceptive activity intraperitoneally administered 3-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-dihydrofuran-2-one (LPP1) pregabalin in chronic constriction injury (CCI) model pain mice evaluated these drugs' influence on motor coordination. In addition, microscopic examinations sciatic nerve were performed...
Villous trophoblast cell turnover in placentas from preterm pregnancy and complicated by intrauterine growth restriction (IUGR).Folia biol
Excessive fructose consumption may lead to metabolic syndrome, dysfunction-associated fatty liver disease (MAFLD) and hypertension. α1-adrenoceptors antagonists are antihypertensive agents that exert mild beneficial effects on the profile in hypertensive patients. However, they no longer used as a first-line therapy for hypertension based Antihypertensive Lipid-Lowering Treatment Prevent Heart Attack Trial (ALLHAT) outcomes. Later studies have shown quinazoline-based α1-adrenolytics...
Introduction: Propolis is used in Poland as an active ingredient of some drugs administered externally, dietary supplements and cosmetics. According to the literature, propolis a non-toxic safe substance, although it may cause allergic contact dermatitis. Aim: The aim this study was assess allergenic properties Balsam Peru. Material methods: conducted according OECD Guideline for testing chemicals-Skin sensitization with use Guinea pig maximization test (GPMT). pigs have similar sensitivity...
Asthma is a chronic inflammatory lung disease. It has been shown that airway remodeling accompanying inflammation represents serious therapeutic problem in asthma pharmacotherapy. Recently, it demonstrated phosphodiesterase (PDE) inhibitors can effectively reduce and remodeling. Based on the structure of theophylline, non-selective PDE inhibitor, we synthesized group its 7,8-disubstituted derivatives characterized them as potent selective against various isoforms, pan-PDE inhibitors. Here...