A5091109378- Heavy metals in environment
- Mercury impact and mitigation studies
- Heavy Metal Exposure and Toxicity
- Integrated Water Resources Management
- Cardiac Imaging and Diagnostics
- Phosphodiesterase function and regulation
- Mast cells and histamine
- Neuroscience and Neuropharmacology Research
- Advanced MRI Techniques and Applications
- Stress Responses and Cortisol
- Botany and Plant Ecology Studies
- Cardiac electrophysiology and arrhythmias
- Receptor Mechanisms and Signaling
- Radioactivity and Radon Measurements
- Cardiovascular Function and Risk Factors
- ECG Monitoring and Analysis
- Geology and Environmental Impact Studies
- Head and Neck Cancer Studies
- Organic and Inorganic Chemical Reactions
- Asthma and respiratory diseases
- Sports Performance and Training
- Birth, Development, and Health
- Synthesis of heterocyclic compounds
- EEG and Brain-Computer Interfaces
- Liver Disease Diagnosis and Treatment
Jagiellonian University
2011-2024
Akademii Wychowania Fizycznego im. Jerzego Kukuczki w Katowicach
2024
Medical University of Lodz
2018-2020
Universitätsklinikum Aachen
2004
Klinik und Poliklinik für Nuklearmedizin
2002
RWTH Aachen University
2002
Silesian University in Opava
1996-2000
Institute of Occupational Medicine and Environmental Health
1995-1999
Śląska Wyższa Szkoła Informatyczno-Medyczna
1994
National Veterinary Research Institute
1991
Action myoclonus-renal failure syndrome is a hereditary form of progressive myoclonus epilepsy associated with renal failure. It considered to be an autosomal-recessive disease related loss-of-function mutations in SCARB2. We studied German AMRF family, additionally showing signs demyelinating polyneuropathy and dilated cardiomyopathy. To test the hypothesis whether isolated appearance individual features could heterozygote SCARB2 mutations, we screened for unrelated patients features. In...
Asthma is a heterogeneous, chronic respiratory disease characterized by airway inflammation and remodeling. Phosphodiesterase (PDE) inhibitors represent one of the intensively studied groups potential anti-asthmatic agents due to their affecting both However, effect inhaled pan-PDE on allergen induced asthma has not been reported date. In this study we investigated impact two, representative strong from group 7,8-disubstituted derivatives 1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione:...
Many studies involving compounds that enhance histamine release, such as H3 receptor (H3R) antagonists, have shown efficacy in inhibiting weight gain, but none passed clinical trials. As part of the search for ligands additional properties, aim this study is to evaluate activity reduction gain a rat model excessive eating, well impact on selected metabolic parameters, and number size adipocytes two new H3R KSK-60 KSK-74, which also exert significant affinity at sigma-2 receptor. Compounds...
Background: Numerous studies highlight the critical role that neural histamine plays in feeding behavior, which is controlled by central H3 and H1 receptors. This fundamental motivation for increased interest creating receptor antagonists as anti-obesity medications. On other hand, multiple neurotransmitter systems have been identified pharmacotherapeutic targets obesity, including sigma-2 systems. Interestingly, our previous rat excessive eating model, we demonstrated a significant...
Abstract Purpose This study aimed to assess the activity of two phosphodiesterase (PDE) inhibitors, namely GRMS-55 and racemic lisofylline ((±)-LSF)) in vitro animal models immune-mediated disorders. Methods Inhibition human recombinant (hr)PDEs TNF-alpha release from LPS-stimulated whole rat blood by studied compounds were assessed . LPS-induced endotoxemia, concanavalin A (ConA)-induced hepatitis, collagen-induced arthritis (CIA) used for vivo evaluation. The potency investigated was...
Most studies have focused on the biodistribution of titanium(IV) oxide as nanoparticles or crystals in organism. But several reports suggested that titanium is released from implant ionic form. Therefore, gaining insight into toxicokinetics Ti ions will give valuable information, which may be useful when assessing health risks long-term exposure to alloy implants patients. A micro synchrotron radiation-induced X-ray fluorescence (µ-SRXRF) was utilized investigate distribution liver, spleen...
Heavy metals and Na, Ca, K were determined in human teeth during 1992/1993 the Polish towns of Katowice Istebna. In relatively clean region southern part Poland (Istebna) content heavy inhabitants was several times lower than (Silesian industrial centre). Ratios concentration Pb : Fe Mn may be an indicator pollution. The analysis correlation matrix shows differences accumulation for two investigated towns. mean Pb, Ni, Cd, Zn, Co, Mn, Cr, Na Ca Istebna significant (p<0.05) according to...
The sequential extraction of different metal forms (exchangeable, carbonate, Mn oxides, Mn–Fe organic, residual) in soil for five locations Istebna during 1992–93 was performed. Two sites were localized a 'clean' region (national park) and the remaining near road. is small, non-industrial mountain town local emission source roadway, where average traffic intensity about 74 cars per hour. One- three-way analyses variance (ANOVA MANOVA, respectively), performed to investigate influence...
In radioiodine therapy of benign thyroid disease, a reduction uptake is known for consecutive administrations 131I, which needs to be considered in planning.Analysis with regard on the time interval between administration and delivered dose tissue.200 patients were enrolled study distributed into two groups (matched diagnoses), each containing 32 Graves' disease (target 250 Gy), 24 focal (400 44 disseminated autonomy (150 Gy). one group, second fraction was given after 48 h (2d) due an...
Hintergrund: Die histologische Aufarbeitung klinisch unverdächtiger Halslymphknoten zeigt bei Kopf-Hals-Karzinomen in ca. 40 % eine zuvor nicht erkannte Metastasierung. Das Vorhandensein von Lymphknotenmetastasen der Primärdiagnostik maligner Kopf-Hals-Tumoren geht mit einer schlechteren Prognose quod vitam einher und fordert aus onkochirurgischer Sicht die Durchführung individuell vorliegenden zu erwartenden Metastasierung angepaßten Form Neck-dissection. Bildgebende Verfahren emöglichen...