A5101749495- Epigenetics and DNA Methylation
- Autophagy in Disease and Therapy
- Cancer, Hypoxia, and Metabolism
- Pancreatic function and diabetes
- Sepsis Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- S100 Proteins and Annexins
- Diabetes and associated disorders
- RNA regulation and disease
- Cancer Research and Treatments
- Amino Acid Enzymes and Metabolism
- Calpain Protease Function and Regulation
- Cardiovascular and Diving-Related Complications
- Blood disorders and treatments
- Ubiquitin and proteasome pathways
- Cell Adhesion Molecules Research
- Cytomegalovirus and herpesvirus research
- Endoplasmic Reticulum Stress and Disease
- Mitochondrial Function and Pathology
- Virus-based gene therapy research
- Metabolism and Genetic Disorders
- Cancer Cells and Metastasis
- RNA modifications and cancer
City of Hope
2016-2023
Abstract Defective arginine synthesis, due to the silencing of argininosuccinate synthase 1 (ASS1), is a common metabolic vulnerability in cancer, known as auxotrophy. Understanding how depletion kills arginine-auxotrophic cancer cells will facilitate development anti-cancer therapeutic strategies. Here we show that extracellular causes mitochondrial distress and transcriptional reprogramming. Mechanistically, starvation induces asparagine synthetase (ASNS), depleting these aspartate,...
Defects in basal autophagy limit the nutrient supply from recycling of intracellular constituents. Despite our understanding prosurvival role macroautophagy/autophagy, how deprivation, caused by compromised autophagy, affects oncogenic KRAS-driven tumor progression is poorly understood. Here, we demonstrate that conditional impairment gene Atg5 (atg5-KO) extends survival KRAS
Up-regulation of hypoxia-inducible factor-1α (HIF-1α), even in normoxia, is a common feature solid malignancies. However, the mechanisms increased HIF-1α abundance, and its role regulating breast cancer plasticity are not fully understood. We have previously demonstrated that dimethyl-2-ketoglutarate (DKG), widely used cell membrane-permeable α-ketoglutarate (α-KG) analogue, transiently stabilizes by inhibiting prolyl hydroxylase 2. Here, we report tumorigenicity can be acquired through...
ABSTRACT Aims/hypothesis Endogenous dsRNAs originating from retrotransposons within the human genome have potential to trigger autoimmunogenic recognition via RIG-like receptors such as MDA5. This phenomenon, known “viral mimicry”, induces potent interferon-beta expression, resulting in cell death and collateral surrounding cells. Viral mimicry has been mostly studied relation epigenetic therapeutics, although there are indications phenomenon is relevant other physiological contexts. Here,...
Abstract Breast cancer is the most prevalent malignant neoplasm among women worldwide and in Taiwan, incidence of breast has been increasing over past years. Accumulating studies shown that multiple stress responses are activated cancer. Oncogene activation, massive proliferation increased nutrient demands often result oxygen deprivation, which triggers integrated response (ISR) tumor cells. ISR dictates cellular adaptive signaling to intrinsic extrinsic stresses, lead endoplasmic reticulum...