A5077247602- Dialysis and Renal Disease Management
- Central Venous Catheters and Hemodialysis
- Muscle and Compartmental Disorders
- Gout, Hyperuricemia, Uric Acid
- Case Reports on Hematomas
- Hepatitis C virus research
- Chronic Kidney Disease and Diabetes
- Blood Pressure and Hypertension Studies
- Acute Kidney Injury Research
- COVID-19 Clinical Research Studies
- Liver Disease and Transplantation
- Hormonal Regulation and Hypertension
- Systemic Sclerosis and Related Diseases
- Vascular Procedures and Complications
- Long-Term Effects of COVID-19
- Hepatitis B Virus Studies
- HIV/AIDS drug development and treatment
- Renal Diseases and Glomerulopathies
- Peripheral Artery Disease Management
- Potassium and Related Disorders
- Nutrition and Health in Aging
- Cardiac Structural Anomalies and Repair
- Vascular anomalies and interventions
- Renal Transplantation Outcomes and Treatments
- Erythropoietin and Anemia Treatment
Hospital General Universitario Gregorio Marañón
2013-2024
Spanish Clinical Research Network
2018-2019
Peking University First Hospital
2015
Peking University
2015
Online haemodiafiltration (OL-HDF) has been shown to reduce all-cause mortality versus conventional haemodialysis (HD); however, it is not always available. In these situations, a novel class of membranes with higher pore size, medium cut-off (MCO) dialysers, could be promising. The aim this study evaluate the efficacy an MCO dialyser in removal small and medium-size molecules compare standard high-flux (HF) dialysers HD OL-HDF.
Purpose Stenosis is the main cause of arteriovenous fistula (AVF) failure. It still unclear whether surveillance based on vascular access blood flow (Q A ) enhances AVF function and longevity. Methods We conducted a three-year follow-up randomized, controlled, multicenter, open-label trial to compare Q -based pre-emptive repair subclinical stenosis with standard monitoring/surveillance techniques in prevalent mature AVFs. AVFs were randomized either control group (surveillance classic alarm...
Background and Aim: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal types cancer; patients die during first 6 months after diagnosis. With a 5% 5-year survival rate, fourth leading cause cancer death in developed countries. In this regard, several clinical, histopathologic biological characteristics disease favoring long-term pancreaticoduodenectomy have been reported to be significant prognostic factors. Despite availability information, there no consensus about different...
In chronic kidney disease (CKD) patients on dialysis, plasma interleukin (IL)-6 levels predict mortality better than other markers. Impact of intraindividual changes inflammatory markers cardiovascular (CV) events in CKD is unknown. The aim this study to demonstrate the relation between CV outcomes and variations C-reactive protein (CRP), IL-6, IL-1β, tumor necrosis factor (TNF)-α CKD. Ninety (mean age: 68.5 ± 12.8 years) at different stages (1-4) were evaluated. Serum CRP, TNF-α measured...
Background Haematuria has been traditionally considered as a benign hallmark of some glomerular diseases; however new studies show that haematuria may decrease renal function. Objective To determine the influence on rate chronic kidney disease (CKD) progression in 71 proteinuric patients with advanced CKD (baseline eGFR <30 mL/min) during 12 months follow-up. Results The mean decline was higher both and proteinuria (haemoproteinuria, HP, n=31) than alone (P patients, n=40) (-3.8±8.9 vs...
<b><i>Background:</i></b> Hepatitis C virus (HCV) infection is highly prevalent among patients on hemodialysis (HD) and associated with poor prognosis. Treatment interferon ribavirin poorly tolerated, few data are available the impact of new direct-acting antivirals (DAAs). This study was intended to analyze efficacy safety treatment a combination ombitasvir/paritaprevir/ritonavir dasabuvir with/without in HCV-infected HD from 3 hospitals....
Background: Mortality in patients with stages 4 and 5 chronic kidney disease (CKD) is higher than the general population. Body composition predicts mortality. Our objective was to evaluate effect of body on mortality non-dialysis CKD. Methods: We performed a prospective study 356 At baseline, we recorded characteristics, history cardiovascular events, composition, serum inflammatory markers, nutrition cardiac biomarkers. analysed using bioimpedance spectroscopy. lean tissue index (LTI), fat...
Hyperuricemia plays a major role in the development and progression of chronic kidney disease (CKD). Many large observational studies have indicated that increased serum uric acid level predicts CKD some population, however this hypothesis has not been yet studied patients with reduced renal mass. Retrospective study cohort 324 mass from an outpatient basis, followed during 60 (36–98) months. Demographics variables, cardiovascular factors, concomitant medications, albuminuria levels were...
New high-retention onset dialysers have shown improved efficacy in the elimination of uraemic toxins, and their depurative capacity has been compared with high convective volumes online haemodiafiltration. Haemodialysis (HD) using high-flux membranes leads to transport by internal filtration [direct (DF)/backfiltration (BF)] allows removal middle molecules (MMs). The aim this study was assess solute mechanisms expanded HD (HDx). In 14 4-h HDx sessions Theranova-500 under similar dialysis...
No consensus has been established as to which is the best fourth-line agent in patients with resistant hypertension (RHT). The aim of present study was assess effect intensifying diuretic treatment loop (furosemide) or aldosterone antagonist (spironolactone) on blood pressure (BP) control RHT.The population comprised 30 RHT who were divided into two arms. Fifteen received furosemide 40 mg/day and 15 spironolactone 25 mg/day. Ambulatory BP monitoring performed baseline, 3 6 months.Baseline...
Abstract Chronic inflammation, protein‐energy wasting, and poor physical functioning are highly prevalent among patients with chronic kidney disease (CKD). These factors associated disability increase of cardiovascular risk. The aim this study is to evaluate the effects exercise training during hemodialysis (HD) sessions on functioning, body composition, nutritional inflammatory status. We performed a prospective intervention including HD therapy. Patients were evaluated at baseline visit by...
Overhydration (OH) is associated with mortality in chronic kidney disease (CKD). A relative overhydration adjusted for extracellular water (OH/ECW) measured by bioimpedance >15% has shown an increased risk haemodialysis but few studies have been developed advanced CKD. Our objective was to evaluate the effect of OH on patients Stage 4 or 5 non-dialysis CKD.We performed a prospective study 356 enrolled 2011 and followed up until 2016. At baseline we collected general characteristics, serum...
Abstract Chronic malnutrition is a common problem in patients with end‐stage renal disease on hemodialysis. Some studies have reported albumin loss into dialysis fluid during postdilution online hemodiafiltration (OL‐HDF). The aim of the study was to assess nutritional status high‐volume OL‐HDF and demonstrate that higher convective clearances are not associated due possible nutrients ultrafiltration. Demographic clinical data, corporal composition bioimpedance spectroscopy, features,...
Dialysis patients have been maintaining a high rate of cardiovascular morbidity and mortality. For this reason, it is to introduce necessary new technical advances in clinical practice. There relation between toxins retention inflammation, mortality morbidity. Medium cut-off (MCO) membranes are generation that allow the removal greater number medium-sized molecules compared with high-flux hemodialysis (HF-HD), but retaining albumin. MCO an increased permeability presence internal filtration....
Low-molecular-weight heparins (LMWHs) are easily dialysable with high-flow membranes; however, it is not clear whether the LMWH dose should be adjusted according to membrane type and dialysis technique. This study aimed evaluate influence of dialyser on anticoagulation extracorporeal circuit.Thirteen patients received same through arterial port via three techniques: high-flux haemodialysis (HF-HD), online haemodiafiltration (HDF) expanded (HDx). All was performed under similar conditions:...
Kidney transplant recipients are at increased risk for infection, including coronavirus disease 2019 (COVID-19), given ongoing immunosuppression. In individuals with COVID-19, complications thrombosis and endothelial dysfunction portend worse outcomes. this report, we describe a kidney recipient who developed severe thrombotic microangiopathy low platelet count (12 ×109/L), anemia (hemoglobin, 7.5 g/dL 7% schistocytes on peripheral-blood smear), acute injury concurrent COVID-19. The clinical...
YKL-40 is a glycoprotein associated with inflammatory conditions, including atherosclerosis and endothelial dysfunction. The objective was to analyse serum levels in haemodialysis population explore their association dialysis dosing measures, inflammation, body composition development of cardiovascular (CV) events.We performed prospective study 78 chronic patients enrolled 2013 followed up until 2018. At baseline, YKL-40, nutrition markers were assessed. During median follow-up 43...
Abstract Low‐density lipoprotein (LDL) apheresis has been considered the last option to treat refractory hyperlipidemia in patients with familiar hypercholesterolemia (FH). Evolocumab is a monoclonal antibody which shown significant reduction of low‐density cholesterol (LDL‐C) serum levels and cardiovascular events. The aim study was examine comparative impact LDL‐apheresis vs combination both on lipid parameters, other metabolic/inflammatory measures. Design Non‐randomized open case series...
The haemodynamic stress brought about by dialysis could justify the loss of structural and functional integrity central nervous system (CNS). main objective this study was to analyse relationship between intradialytic hypotension (IDH) cognitive function brain morphometry.The cross-sectional KIDBRAIN (Cohort Study Morphological Changes Brain MRI in Chronic Kidney Disease Patients) included 68 prevalent patients with no history neurological disorders (cerebrovascular disease impairment)...
La infección por el virus de la hepatitis C (VHC) es muy prevalente entre los pacientes en hemodiálisis y condiciona un peor pronóstico respecto a que no padecen. El tratamiento con interferón ribavirina mal tolerado existen pocos datos sobre experiencia nuevos antivirales acción directa (AAD). objetivo este trabajo estudiar retrospectivamente prevalencia actual VHC resultados eficacia seguridad distintas pautas AAD población 2 áreas hospitalarias. Estudio multicéntrico, retrospectivo...
A good vascular access (VA) is vital for haemodialysis (HD) patients. HD with an autologous arteriovenous fistula (AVF) associated higher survival, lower health care costs and fewer complications. Although a distal forearm AVF the best option, not all patients are candidates this approach primary failure rate ranges from 20% to 50%. The optimal depends mainly on anatomical haemodynamic characteristics of artery vein chosen anastomosis. These can be modified by performing physical exercise....