A5087157691- Analytical Chemistry and Chromatography
- Bioactive Compounds and Antitumor Agents
- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- Retinal Imaging and Analysis
- Inhalation and Respiratory Drug Delivery
- Layered Double Hydroxides Synthesis and Applications
- Inorganic and Organometallic Chemistry
- Morinda citrifolia extract uses
- Antibiotics Pharmacokinetics and Efficacy
- Retinal Diseases and Treatments
- Analytical Methods in Pharmaceuticals
- Advancements in Transdermal Drug Delivery
- Nanomaterials for catalytic reactions
- Antimicrobial Peptides and Activities
- Chemical Reaction Mechanisms
- Ocular Diseases and Behçet’s Syndrome
- Lipid Membrane Structure and Behavior
- Drug Transport and Resistance Mechanisms
- Synthesis of Organic Compounds
- Nanoparticles: synthesis and applications
- Bacterial biofilms and quorum sensing
- Covalent Organic Framework Applications
- Cancer therapeutics and mechanisms
- Antimicrobial agents and applications
Universidad Nacional de Córdoba
2007-2025
Consejo Nacional de Investigaciones Científicas y Técnicas
2014-2025
University of Michigan
2007
Gentamicin (GEN), a widely used broad-spectrum antibiotic, faces challenges amid the global emergency of antimicrobial resistance. This study aimed to explore synergistic effects zinc oxide nanoparticles (ZnO NPs) in combination with GEN on bactericidal activity against various bacterial strains. Results showed ZnO NPs MICs ranging from 0.002 1.5 μg/mL, while precursor salt displayed MIC range 48.75–1560 μg/mL. Chitosan (CS)-capped exhibited even lower than their uncapped counterparts,...
Rifampicin is a broad-spectrum antibiotic, active against several bacterial infections such as tuberculosis. It relatively large and structurally complex molecule, including numerous polar groups. Although violating of Lipinski’s rules for efficient intestinal absorption, rifampicin shows good oral bioavailability, permeating through cell membranes in the absorption pathway those target organisms. Some hypotheses have been proposed its membrane permeation, but details are mostly unknown. In...
Rifampicin is a broad-spectrum antibiotic, active against several bacterial infections such as tuberculosis. It relatively large and structurally complex molecule, including numerous polar groups. Although violating of Lipinski’s rules for efficient intestinal absorption, rifampicin permeates through cell membranes its target organisms shows good oral bioavailability. Some hypotheses have been proposed membrane permeation, but the details are mostly unknown. In this work, interaction with...
The therapeutic effects of Argentine propolis ear drop formulation on canine otitis externa were evaluated. Forty-eight dogs with symptoms randomly assigned to double-blinded, controlled clinical trial evaluate the efficacy topical versus a placebo in treatment externa. preparation and administrated into both external canals, twice daily for 14 days. Throughout study, examination microbiological analysis exudates made. most frequent microorganisms isolated culture media were: Malassezia...
Ranibizumab and bevacizumab coexist as the main therapeutic strategies for treatment of neovascular age-related macular degeneration (NV-AMD). In Argentina, access pathways to drugs are different. Patients with different gatekeepers may experience outcomes. The purpose this work was estimate impact on effects visual outcome accessibilities NV-AMD treatment. A retrospective analysis charts 78 patients previously untreated exudative AMD, who were treated ranibizumab or between January 2009...
The intracellular concentration of rifampicin (RIF) loaded into chitosan (CS)/Tween 80 (T80)-coated alginate nanoparticles determined by a validated RP-HPLC method and fluorescence microscopy studies demonstrated that the promote cellular internalization RIF.
Nanotechnology is a very promising technological tool to combat health problems associated with the loss of effectiveness currently used antibiotics. Previously, we developed formulation consisting chitosan and tween 80-decorated alginate nanocarrier that encapsulates rifampicin antioxidant ascorbic acid (RIF/ASC), intended for treatment respiratory intracellular infections. Here, investigated effects RIF/ASC-loaded NPs on mucus pulmonary surfactant. In addition, evaluated their cytotoxicity...
Introduction: Cyclodextrins (CD), are known to form inclusion complexes with a variety of guest molecules both in solution and the solid state. This can lead alteration properties molecules. Unfortunately, complexation efficiency CD is rather low, be enhanced by formation ternary using aminoacids (AA). Sulfadiazine (SDZ) an antibiotic extremely low water solubility which limits its therapeutic applications bioavailability. Objetives: The aim this work was increase aqueous SDZ preparing drug...
Abstract The lipophilic character of a series new isoxazolyl-naphthoquinones has been studied. Partition chromatography procedures (RP-HPLC and RP-TLC) were developed for determining the log Po-w(n-octanol/water partition coefficient) values. experimental values from these methods validated by comparison with those obtained conventional shake flask method, except more because they have poor water solubility. Also, Po-w was calculated using CLOGP computer programme. ACKNOWLEDGMENTS authors...
Current cancer chemotherapy is associated with many side effects and, in some cases, drug resistance, which makes the search for new active molecules and delivery strategies imperative. Carbamazepine an antiepileptic compound that has shown efficacy against breast cell lines. In this study, it was incorporated into layered double hydroxide nanoclays, percentage of loading increased compared to previous research, clays were impregnated magnetic Fe3O4 nanoparticles. The goal Fe3O4-impregnation...
The purpose of the present study was to investigate interaction between both hydroxypropyl-β-cyclodextrin (HP-β-CD) and PVP-K30 with 2-hydroxy-N-(3-methyl-5-ethyl-4-isoxazolyl)-1,4-naphthoquinone-4-imina (I), a synthetic derivative isoxazolylnaphthoquinones that has demonstrated exhibit important biological activity against S. aureus T. cruzi. continuous variation plot for I–HP-β-CD system showed 1:1 stoichiometry complex. Ultraviolet absorption spectroscopy indicates isoxazole moiety I is...
G. E. Granero, M. de Bertorello and C. Briñón, J. Chem. Res. (S), 1999, 110 DOI: 10.1039/A806065G
Abstract Carbamazepine (CBZ) was incorporated into Layered Double Hydroxides (LDH) to be used as controlled drug delivery in solid tumors. CBZ has a formal charge of 0, which implies challenge the anionic clay. Aiming overcome this problem, first micelles sodium cholate (SC), surfactant with negative charge. SC and, for comparison, free were LDH by reconstruction method. It found that resultant nano-composites had similar encapsulation efficiency, around 75 %, but release simulated body...