A5034619894- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Muscle Physiology and Disorders
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Inflammation biomarkers and pathways
- Exercise and Physiological Responses
- Stress Responses and Cortisol
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Eicosanoids and Hypertension Pharmacology
- Antioxidant Activity and Oxidative Stress
- Nicotinic Acetylcholine Receptors Study
- Neurological Disease Mechanisms and Treatments
- Pluripotent Stem Cells Research
- Nutrition and Health in Aging
- Genomics, phytochemicals, and oxidative stress
- Cystic Fibrosis Research Advances
- Tryptophan and brain disorders
- Circadian rhythm and melatonin
- Sodium Intake and Health
- Respiratory and Cough-Related Research
- Medical and Biological Ozone Research
- Adipose Tissue and Metabolism
- Asthma and respiratory diseases
- Intensive Care Unit Cognitive Disorders
- Renal and related cancers
O'Brien Institute
2024
RMIT University
2019-2023
MIT University
2020-2022
Skeletal muscle dysfunction in patients with chronic obstructive pulmonary disease negatively impacts quality of life and survival. Cigarette smoking (CS) is the major risk factor for skeletal dysfunction; however, how CS affects function remains enigmatic. To examine impact on inflammation regeneration, male BALB/c mice were exposed to 8 weeks before injury was induced by barium chloride injection, maintained protocol up 21 days after injury. Barium injection resulted architectural damage...
Background and Objective Neurocognitive dysfunction is present in up to ∼61% of people with chronic obstructive pulmonary disease (COPD), symptoms including learning memory deficiencies, negatively impacting the quality life these individuals. As mechanisms responsible for neurocognitive deficits COPD remain unknown, we explored whether cigarette smoke (CS) exposure causes mice this associated neuroinflammation an altered neuropathology. Methods Male BALB/c were exposed room air (sham) or CS...
Background and Purpose It is well established that both smokers patients with COPD are at a significantly heightened risk of cardiovascular disease (CVD), although the mechanisms underpinning onset progression co‐morbid CVD largely unknown. Here, we explored whether cigarette smoke (CS) exposure impairs vascular function in mice given well‐known pathological role for oxidative stress COPD, antioxidant compound ebselen prevents CS‐induced dysfunction mice. Experimental Approach Male BALB/c...
Cigarette smoking (CS) is the leading cause of chronic obstructive pulmonary disease (COPD). The "spill-over" inflammation into systemic circulation may damage brain, to cognitive dysfunction. Cessation CS can improve and neurocognitive outcomes, however, its benefit on neuroinflammatory profile remains uncertain. Here, we investigate how exposure impairs neurocognition whether this be reversed with cessation or an antioxidant treatment.Male BALB/c mice were exposed (9 cigarettes/day for 8...
Background and Purpose Cardiovascular disease affects up to half of the patients with chronic obstructive pulmonary (COPD), exerting deleterious impact on health outcomes survivability. Vascular endothelial dysfunction marks onset cardiovascular disease. The present study examined effect a potent NADPH Oxidase (NOX) inhibitor free‐radical scavenger, apocynin, COPD‐related Experimental Approach Male BALB/c mice were exposed either room air (Sham) or cigarette smoke (CS) generated from 9...
Chronic obstructive pulmonary disease (COPD) is a major, incurable respiratory condition that primarily caused by cigarette smoking (CS). Neurocognitive disorders including cognitive dysfunction, anxiety and depression are highly prevalent in people with COPD. It understood increased lung inflammation oxidative stress from CS exposure may 'spill over' into the systemic circulation to promote onset of these extra-pulmonary comorbidities, thus impacts quality life The precise role 'spill-over'...
Background & AimsLiver sinusoidal endothelial cells (LSECs) are important in liver development, regeneration and pathophysiology, but the differentiation process underlying their tissue-specific phenotype is poorly understood difficult to study as primary human scarce. The aim of this was use induced pluripotent stem cell (hiPSC)-derived LSEC-like investigate LSECs.MethodshiPSC-derived were transplanted into livers Fah−/−/Rag2−/−/Il2rg−/− mice assessed over a 12-week period. Lineage tracing,...
Background and Purpose Skeletal muscle dysfunction is a major comorbidity of chronic obstructive pulmonary disease (COPD). This type may be direct consequence oxidative insults evoked by cigarette smoke (CS) exposure. The present study examined the effects potent Nox inhibitor reactive oxygen species (ROS) scavenger, apocynin, on CS‐induced dysfunction. Experimental Approach Male BALB/c mice were exposed to either room air (sham) or CS generated from nine cigarettes per day, 5 days week for...
People with chronic obstructive pulmonary disease (COPD) are susceptible to respiratory infections which exacerbate and/or cardiovascular complications, increasing their likelihood of death. The mechanisms driving these complications remain unknown but increased oxidative stress has been implicated. Here we investigated whether influenza A virus (IAV) infection, following cigarette smoke (CS) exposure, worsens vascular function and if so, the antioxidant ebselen alleviates this dysfunction....
Abstract Gastrointestinal (GI) dysfunction is a common comorbidity of chronic obstructive pulmonary disease (COPD) for which major cause cigarette smoking (CS). The underlying mechanisms and precise effects CS on gut contractility, however, are not fully characterised. Therefore, the aim present study was to investigate whether impacts GI function structure in mouse model CS-induced COPD. We also aimed presence ebselen, an antioxidant that has shown beneficial lung inflammation resulting...
Limb muscle dysfunction is a hallmark of Chronic Obstructive Pulmonary Disease (COPD) which further worsened following viral-induced acute exacerbation COPD (AECOPD). An amplified airway inflammation underlies the aggravated respiratory symptoms seen during AECOPD, however, its contributory role to limb unclear. The present study examined impact influenza A virus (IAV)-induced on hind parameters. Airway was established in male BALB/c mice by exposure cigarette smoke (CS) for 8 weeks....
Background and Purpose: Cigarette smoking (CS) is the major risk factor for developing COPD related skeletal muscle dysfunction. It has been postulated that CS exposure may directly causes dysfunction via induction of oxidative stress. The present study examined effect a potent Nox inhibitor ROS scavenger, apocynin on CS-induced Experimental Approach: Male BALB/c mice were exposed to either room air (sham) or generated from 9 cigarettes per day, 5 days week 8 weeks with without treatment (5...
Background and Purpose: It is well established that both smokers patients with COPD are at a significantly heightened risk of cardiovascular disease (CVD), although the mechanisms underpinning onset progression comorbid CVD largely unknown. Here, we explored whether cigarette smoke (CS) exposure impairs vascular function in mice given well-known pathological role for oxidative stress COPD, antioxidant compound ebselen prevents CS-induced dysfunction mice. Experimental Approach: Male BALB/c...
Background and Purpose: People with COPD are susceptible to respiratory infections which exacerbate pulmonary and/or cardiovascular complications, increasing their likelihood of death. The mechanisms driving these complications remain unknown but increased oxidative stress has been implicated. Here we investigated whether influenza A virus (IAV) infection, following chronic cigarette smoke (CS) exposure, worsens vascular function if so, the antioxidant ebselen alleviates this dysfunction....
Background and Purpose: Cardiovascular disease (CVD) affects up to half of the patients with chronic obstructive pulmonary (COPD), which exerts deleterious impact on health outcomes survivability. Vascular endothelial dysfunction marks onset cardiovascular disease. The present study examined effect a potent NADPH Oxidase (NOX) inhibitor free-radical scavenger, apocynin, COPD-related CVD. Experimental Approach: Male BALB/c mice were exposed either room air (Sham) or cigarette smoke (CS)...
Abstract Background: Cigarette smoking (CS) is the leading cause of chronic obstructive pulmonary disease (COPD). The “spill-over” inflammation into systemic circulation may damage brain, to cognitive dysfunction. Cessation CS can improve and neurocognitive outcomes, however, its benefit on neuroinflammatory profile remains uncertain. Here, we investigate how exposure impairs neurocognition whether this be reversed with cessation or an antioxidant treatment. Methods: Male BALB/c mice were...