A5028294256- Advanced Neuroimaging Techniques and Applications
- Multiple Sclerosis Research Studies
- Cerebral Venous Sinus Thrombosis
- Dementia and Cognitive Impairment Research
- MRI in cancer diagnosis
- Advanced MRI Techniques and Applications
- Neurological Disease Mechanisms and Treatments
- Systemic Lupus Erythematosus Research
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- RNA regulation and disease
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurology and Historical Studies
- Williams Syndrome Research
- Mental Health and Psychiatry
- Neonatal and fetal brain pathology
- Genetics and Neurodevelopmental Disorders
- Cognitive Functions and Memory
- Autism Spectrum Disorder Research
- Acute Ischemic Stroke Management
- Glaucoma and retinal disorders
Walter and Eliza Hall Institute of Medical Research
2020-2022
The University of Melbourne
2016-2020
Florey Institute of Neuroscience and Mental Health
2020
Long term irreversible disability in multiple sclerosis (MS) is thought to be primarily driven by axonal degeneration. Axonal degeneration leads degenerative atrophy, therefore early markers of are required predict clinical and treatment efficacy. Given that additional pathologies such as inflammation, demyelination oedema also present MS, it essential develop not confounded these processes. The study investigated a novel method for measuring MS based on high angular resolution diffusion...
Diffusion MRI has provided the neuroimaging community with a powerful tool to acquire in-vivo data sensitive microstructural features of white matter, up 3 orders magnitude smaller than typical voxel sizes. The key extracting such valuable information lies in complex modelling techniques, which form link between rich diffusion and various metrics related organisation. Over time, increasingly advanced techniques have been developed, point where some models can now provide access properties...
Cognitive dysfunction can be identified in patients with clinically isolated syndromes suggestive of multiple sclerosis using ocular motor testing. This study aimed to identify the functional neural correlates cognitive syndrome MRI. Eighteen and 17 healthy controls were recruited. Subjects underwent standard neurological neuropsychological also MRI (fMRI) during a task, involving pro-saccade (direct gaze towards target) anti-saccade away from trials. Ocular performance variables (averaged...
Executive dysfunction has been demonstrated among premutation (PM) carriers (55-199 CGG repeats) of the Fragile X mental retardation 1 (FMR1) gene. Further, alterations to neural activation patterns have reported during memory and comparison based functional magnetic resonance imaging (fMRI) tasks in these carriers. For first time, relationships between fMRI an interleaved ocular motor prosaccade/antisaccade paradigm, concurrent task performance (saccade measures latency, accuracy error...
Abstract Endpoint-to-endpoint fibre bundle connectivity estimated using spherical deconvolution & streamlines tractography in diffusion MRI may be excessive the presence of pathologies that involve truncation axons within white matter. Here we propose a simple modification to an existing method directly quantifies and corrects for this over-estimation.
Amyloid-beta often co-exists in dementia with Lewy bodies, but its clinical relevance bodies remains unclear. This study aimed to investigate the and imaging correlates of amyloid-beta deposition particularly relationship cortical thickness Alzheimer's disease-prone regions hippocampal volume.Twenty-four participants probable underwent high-resolution magnetic resonance positron emission tomography using radiotracer 18F-NAV4694. was quantified reported Centiloid method.Amyloid-beta...
Abstract Background Cerebellar damage is common in people with multiple sclerosis (pwMS) and associated worse progression relapse recovery. Studies into the importance of cerebellum pwMS are hampered by limited understanding cerebellar its relation to function pwMS. Objective Examine axonal loss, as a primary driver progressive neurological decline, using advanced diffusion MRI compare loss dysfunction Methods We recruited 55 14 healthy controls. Clinical assessments included scale for...
Biomarkers are urgently required for predicting the likely progression of multiple sclerosis (MS) at earliest stages disease to aid in personalised therapy.We aimed examine early brain volumetric and microstructural changes retinal nerve fibre layer thinning as predictors longer term MS severity patients with clinically isolated syndromes (CIS).Lesion metrics, regional atrophy, diffusion fractional anisotropy thickness were prospectively assessed 36 CIS over first 12 months after...
Abstract The white matter is highly vascularised by the cerebral venous system. neuroinflammatory disease multiple sclerosis associated with infiltration of peripheral immune cells into brain via these vessels. Understanding pathophysiology in thus critical for understanding early aetiology. In this paper, we describe a unique blood oxygen-level dependent (BOLD) signal within using functional MRI and spatial independent components analysis, blind source separation method. was characterised...
The white matter is highly vascularised by the cerebral venous system. In this paper, we describe a unique blood oxygen-level dependent (BOLD) signal within using functional MRI and spatial independent components analysis. characterized narrow peak frequency band between 0.05 0.1 Hz. Hypercapnia, induced transient increases in BOLD that disrupted oscillation indicative of vasocontractile mechanism. Comparison oscillations 14 healthy subjects 18 people with perivenular inflammation due to...
Abstract Background Dementia with Lewy bodies (DLB) is a neurodegenerative disorder characterized pathologically by the deposition of alpha synuclein. Many patients DLB also have brain compatible Alzheimer’s disease (namely Amyloid‐β and tau), which can lead to challenges clinical diagnosis management. In this study we aim understand influence Aβ on atrophy in patients. Method 19 participants probable underwent 3T MRI T1‐weighted (voxel size=0.8x0.8x0.8mm 3 , TR=2400ms, TE=2.31ms) β‐amyloid...