Pulmonary nodules (PNs) are a common reason for referral to pulmonologists. The majority of data the evaluation and management PNs is derived from studies performed in academic medical centers. Little known about prevalence diagnosis PNs, use diagnostic testing, or by community pulmonologists.This multicenter observational record review evaluated 377 patients aged 40 89 years referred 18 geographically diverse pulmonary practices intermediate (8-20 mm). Study measures included malignancy,...

Continuous glucose monitoring (CGM) has been shown to improve glycemic control and reduce hypoglycemia with consistent use. Youth, however, are unlikely use CGM consistently. We compared psychological characteristics of youth type 1 diabetes, their parents, adults diabetes randomized or standard blood (BGM). This study was an ancillary study, participants completed the questionnaires at 6-month visit main study.Participants enrolled a single site Juvenile Diabetes Research Foundation trial...

Summary Background Chronic hepatitis C virus ( HCV ) infection and its treatment impact patients' health‐related quality of life HRQL ). Aim To report on predictors among treatment‐naïve patients with genotype 1 chronic who received 12‐week telaprevir (T) 24 (T12PR24) or 48 weeks (T12PR48) peginterferon alpha‐2a/ribavirin PR ), in the ADVANCE study. Methods The EQ‐5D‐3L (EQ‐5D) questionnaire (index range: 0–1) was completed at baseline 4, 12, 24, 36, 72. Patients indicated their health state...

Introduction The Cohen-Mansfield Agitation Inventory (CMAI) quantifies the frequency of agitation behaviors in elderly persons. This post hoc analysis data from brexpiprazole clinical program aimed to determine a meaningful within-patient change (MWPC) threshold for CMAI Total score among patients with associated dementia due Alzheimer’s disease. Methods Data were included three 12-week, multicenter, randomized, double-blind, placebo-controlled, parallel-arm trials treatment disease (...

Infection with hepatitis C virus (HCV) is associated high morbidity and increased mortality but many patients avoid initiation of treatment or report challenges completion. The study objective was to identify motivators barriers for completion in a community sample HCV-infected the United States.Survey methods were employed factors reported by as important their decision start complete HCV treatment. Study participants included 120 individuals: 30 had previously completed pegylated...

Pulmonologists frequently encounter indeterminate pulmonary nodules in practice, but it is unclear what clinical factors they rely on to guide the diagnostic evaluation.To assess current approach management of and determine extent which addition a hypothetical blood test will influence decision making.Selected pulmonologists practicing United States were invited participate conjoint exercise based 20 randomly generated cases varying age, smoking history, nodule size. Some included result...

BACKGROUND The impact of subsequent metastases on costs and medical resource use (MRU) for prostate cancer (PC) patients initially diagnosed with localized disease was estimated. METHODS Surveillance, Epidemiology, End Results data, linked to Medicare (1999‐2012), were used identify 7482 12 months or more after the initial diagnosis PC (cases), they matched 25,709 without (controls). Patients followed MRU from before their index date (subsequent a controls) up it. Costs stratified by...

Ezetimibe is recommended by clinical practice guidelines as a second-line therapy for lowering low-density lipoprotein cholesterol (LDL-C) levels, but little known about its use and effectiveness in real-world populations.To understand the impact of adding or switching to ezetimibe on LDL-C goal achievement patients with atherosclerotic cardiovascular disease (ASCVD) and/or heterozygous familial hypercholesterolemia (HeFH).Patients aged ≥ 18 years an measurement available between January 1,...

The present study aimed to establish a better marker for the assessment of coronary artery disease (CAD). One hundred patients CAD (aged 20–60 years) both sex and hypertension with symptoms were selected study.50 age matched healthy controls chosen study. Serum total cholesterol, triglycerides HDL-C estimated in Simens Dimensions RxL. LDL-C, VLDL-C calculated by Friedwald Formula while non-HDL-C was subtracting level from cholesterol level. comparison friedwald LDL-C made terms...

To describe and compare clinical characteristics, healthcare costs, institutionalization/mortality outcomes among patients with without agitation associated Alzheimer's dementia (AAD).Data from the Reliant Medical Group database (01/01/2016-03/31/2020) were used, including claims, electronic medical records, information/physician notes abstracted charts. Patients aged ≥55 years (AD) observed during a randomly selected 12-month study period after AD diagnosis. Using information recorded in...

Summary Work productivity is impacted in hepatitis C virus ( HCV )‐infected patients and has been linked to treatment. In two Phase 3 trials, ADVANCE ILLUMINATE , treatment‐naïve genotype 1 chronic ‐infected received 12‐week telaprevir T ) with 24 12 PR 24)‐ or 48 48)‐week peginterferon alfa‐2a/ribavirin. The objective of this analysis was examine the impact infection its treatment combination therapy on work productivity. 5‐item, self‐reported questionnaire WPQ administered trials assess...

Parasitic infections like filariasis are uncommon causes of secondary membranous nephropathy (MN) which requires serological tests to detect circulating Wuchereria bancrofti antigens for its diagnosis or the identification microfilariae in capillary lumen on kidney biopsy. The immunochromatographic card is simple, non invasive and has high sensitivity specificity. We report a case 30 year old lady who presented us with nephrotic syndrome biopsy showed features negative staining Anti PLA2R,...

e18754 Background: The value of using next-generation sequencing (NGS) to inform oncology care decisions is increasingly apparent, yet many challenges persist that may inhibit routine adoption NGS into clinical care. purpose this study was identify existing barriers access and possible solutions from the physician perspective. Methods: A cross-sectional online survey, including both closed- open-ended questions, sent a nationally representative sample oncologists/hematologists, surgeons,...

Objective: To compare the cost-effectiveness of epoetin alfa (EPO) and darbepoetin (DARB) for treatment chemotherapy-induced anemia (CIA), using dosing regimens approved by FDA (EPO 40 000 U once weekly DARB 2.25 mcg/kg weekly).Methods: The study compared published results two double-blind, randomized, phase III trials one utilizing EPO (N = 166) other, 367). Patients in both had similar baseline characteristics. Effectiveness was measured as proportion or patients who were successfully...

Objective: Lithium is a principal drug used in the treatment of bipolar disorder (BPD). Due to its narrow therapeutic index, serum levels need be monitored regularly. In elderly patients with renal dysfunction lithium toxicity can develop paradoxically within range. This lead erroneous diagnosis and delayed resulting irreversible neurological sequelae as described our case. Case Presentation: A 65-year-old hypertensive female, 7-year history BPD presented decreased oral intake since 5-7...