A5050163981- Carbohydrate Chemistry and Synthesis
- Glycosylation and Glycoproteins Research
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- RNA Interference and Gene Delivery
- Click Chemistry and Applications
- Advanced Drug Delivery Systems
- Nanoparticle-Based Drug Delivery
- Lipid Membrane Structure and Behavior
- Bacteriophages and microbial interactions
- Escherichia coli research studies
- Enterobacteriaceae and Cronobacter Research
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Chemical Synthesis and Analysis
- Bee Products Chemical Analysis
- SARS-CoV-2 and COVID-19 Research
- interferon and immune responses
- Animal Virus Infections Studies
- Amino Acid Enzymes and Metabolism
- Protein Structure and Dynamics
- RNA and protein synthesis mechanisms
- COVID-19 Clinical Research Studies
- Synthesis and Reactivity of Sulfur-Containing Compounds
Université du Québec à Montréal
2017-2024
BioPhage Pharma (Canada)
2020
Institut National de la Recherche Scientifique
2018-2019
ConspectusPreventing bacterial adhesion to host cells is a provocative and alternative approach traditional antibiotic treatments given the increasing microbial resistance. A brief overview of common described in light their respective resistance remaining susceptibility. This strategy has been seriously considered context adherent-invasive infections Crohn's disease urinary tract particular. The adhesions various pathogenic Escherichia coli strains are primarily mediated through...
Glycodendrimers have attracted considerable interest in the field of dendrimer sciences owing to their plethora implications biomedical applications. This is primarily due fact that cell surfaces expose a wide range highly diversified glycan architectures varying by nature sugars, number, and natural multiantennary structures. particular situation has led cancer metastasis, pathogen recognition adhesion, immune communications are implicated vaccine development. The diverse complexity...
Selective antiadhesion antagonists of Uropathogenic Escherichia coli (UPEC) type-1 Fimbrial adhesin (FimH) are attractive alternatives for antibiotic therapies and prophylaxes against acute or recurrent urinary tract infections (UTIs) caused by UPECs. A rational small library FimH based on previously described C-linked allyl α-D-mannopyranoside was synthesized using Heck cross-coupling reaction a series iodoaryl derivatives. This work reports two new members antagonist amongst the above...
Antagonists of the Escherichia coli type-1 fimbrial adhesin FimH are recognized as attractive alternatives for antibiotic therapies and prophylaxes against acute recurrent bacterial infections. In this study α-d-mannopyranosides O- or C-linked with an alkyl, alkene, alkyne, thioalkyl, amide, sulfonamide were investigated to fit a hydrophobic substituent up two aryl groups within tyrosine gate emerging from mannose-binding pocket FimH. The results summarized into set structure-activity...
Conjugation of carbohydrates to nanomaterials has been extensively studied and recognized as an alternative in the biomedical field. Dendrimers synthesized with mannose at end group entrapped zero-valent copper/silver could be a potential candidate against bacterial proliferation. This study is aimed investigating bactericidal activity metal-glycodendrimers. The Cu(I)-catalyzed azide–alkyne cycloaddition (CuAAC) reaction was used synthesize new mannosylated dendrimer containing 12...
Glycosylated NPs, including liposomes, are known to target various receptors involved in cellular carbohydrate transport, of which the mannoside binding attracting particular attention for their expression on immune cells, cancers, and cells maintaining central nervous system (CNS) integrity. As part our interest NP drug delivery, mannosylated glycoliposomal delivery systems formed from self-assembly amphiphilic neoglycolipids were developed, with a C12-alkyl mannopyranoside (ML-C12) being...
Cancer treatment remains unsatisfactory with high rates of recurrence and metastasis. Immunomodulatory agents capable promoting cellular antitumor immunity while inhibiting the local immunosuppressive tumor microenvironment could greatly improve cancer treatment. We have developed a multi-targeted mannosylated cationic liposome delivery system containing muramyl dipeptide (DS) low doses chemotherapeutic agent cytarabine (Ara-C). Immunomodulation primary immune cells immortalized cell lines...
Perhaps the greatest limitation for continually advancing developments in cancer immunotherapy remains immunosuppressive tumor microenvironment (TME). The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) axis is an emerging target, with resulting type I interferons and transcription factors acting at several levels both immune cells generation adaptive T cell responses. cGAS-STING activation by therapeutic agents that induce DNA damage, such as certain chemotherapies,...
A set of three mannopyranoside possessing identical 1,1'-biphenyl glycosidic pharmacophore but different aglyconic atoms were synthesized using either a palladium-catalyzed Heck cross coupling reaction or metathesis between their corresponding allylic glycoside derivatives. Their X-ray structures, together with calculated 3D showed strong indicators to explain the observed relative binding abilities against E. coli FimH as measured by improved surface plasmon resonance (SPR) method. Amongst...
Peptide therapeutics offer numerous advantages in the treatment of diseases and disorders central nervous system (CNS). However, they are not without limitations, especially terms their pharmacokinetics where metabolic lability low blood–brain barrier penetration hinder application. Targeted nanoparticle delivery systems being tapped for ability to improve into brain non-invasively. We have developed a family mannosylated glycoliposome targeted drug applications. Herein, we demonstrate via...
Label-free detection of pathogens is major concern to the microbiologist community. Most procedures require several steps and amplification techniques. Carbohydrates are well-established receptors for host–pathogen interactions, which can be amplified using glycodendritic architectures on basis multivalent binding interactions. Given that uropathogenic Escherichia coli bacterial FimH based such mannopyranoside-binding we demonstrate herein synthetic monomeric trimeric thiolated...
The chemical synthesis of modified neoglycolipids is reported in an effort to further improve the drug delivery properties previously described mannosylated liposomes possessing alkyl linkers aglyconic moiety.
C-Allyl -D-mannopyranosides were prepared via a variety of routes to determine an optimal route the anomers.The relative conformational energies key intermediate was evaluated by molecular modeling which showed conventional 4 C1 chair conformation be lowest energy conformer.This finding also confirmed NMR and X-ray crystallography.The perbenzoylated C-allyl mannoside converted into 1,1'-biphenyl analogues using palladium-catalyzed Heck reaction.Two resulting minor reaction products...
Antagonists of the uropathogenic Escherichia coli type-1 fimbrial adhesin (FimH) are recognized as attractive alternatives for antibiotic therapies and prophylactic strategies against acute recurrent bacterial infections. [...]