A5100659167- Ovarian function and disorders
- Reproductive Biology and Fertility
- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Berberine and alkaloids research
- Endometrial and Cervical Cancer Treatments
- Nanoplatforms for cancer theranostics
- Ginseng Biological Effects and Applications
- Ovarian cancer diagnosis and treatment
- Lipid metabolism and disorders
- Luminescence and Fluorescent Materials
- Phytochemistry and biological activities of Ficus species
- Uterine Myomas and Treatments
- Cancer-related molecular mechanisms research
- Pregnancy and preeclampsia studies
- Hypothalamic control of reproductive hormones
- Plant-based Medicinal Research
- Pregnancy-related medical research
- Anesthesia and Neurotoxicity Research
- Autophagy in Disease and Therapy
- Cardiac electrophysiology and arrhythmias
- Gastrointestinal motility and disorders
- Cervical Cancer and HPV Research
- Photochromic and Fluorescence Chemistry
- Sperm and Testicular Function
Fudan University Shanghai Cancer Center
2022-2025
Yunnan University
2024-2025
Ministry of Education of the People's Republic of China
2025
Huazhong Agricultural University
2023-2025
Obstetrics and Gynecology Hospital of Fudan University
2007-2024
Fudan University
2013-2024
State Key Laboratory of Genetic Engineering
2016-2024
Shanghai Medical College of Fudan University
2014-2024
University of Science and Technology of China
2024
Huazhong University of Science and Technology
2023-2024
A planar conjugated ligand functionalized with bithiophene and its Ru(II), Os(II), Ir(III) complexes have been constructed as single-molecule platform for synergistic photodynamic, photothermal, chemotherapy. The significant two-photon absorption at 808 nm remarkable singlet oxygen superoxide anion production in aqueous solution cells when exposed to infrared irradiation. most potent Ru(II) complex Ru7 enters tumor via the rare macropinocytosis, locates both nuclei mitochondria, regulates...
Abstract Aim The aim of this study was to determine the frequency various symptoms and their associated characteristics in women with adenomyosis who underwent hysterectomy, which are likely go others these patients. Material Methods In 2007, 1697 consecutive patients hysterectomy our hospital. Among them, 734 (43.3%) were histologically confirmed have adenomyosis, 710 them premenopausal. medical charts all retrieved, demographic, clinical information postoperative findings recorded. We used...
Background Cellular adaptation to a hypoxic microenvironment is essential for tumor progression and largely mediated by HIF-1α through coordinated regulation of hypoxia-responsive genes. The chemokine SDF-1α its unique receptor CXCR4 have been implicated in organ-specific metastases many cancers. In this study, we investigated the response osteosarcoma cells hypoxia expression human specimens explored roles cell migration process. Methodology/Principal Findings We performed...
Abstract Background Polycystic ovary syndrome (PCOS) is a common endocrine disease of the female reproductive system that seriously affects women’s health. Berberine (BBR) has many pharmacological properties and used as an insulin sensitizer. This study aimed to investigate effect BBR on PCOS explore its related mechanisms. Methods Forty-two rats were randomly divided into following six groups ( n = 7 per group): control, control + BBR, PCOS-normal diet (ND), PCOS-ND PCOS-high-fat (HFD),...
Abstract Background Investigating the underlying molecular mechanisms responsible for endometrial dysfunction in women with PCOS is essential, particularly focusing on role of hyperinsulinemia. Methods We explored insulin decidualization process using a synthetic assay. To dissect effects PI3K/AKT-NR4A signaling, we employed small interfering RNAs (siRNAs) targeting NR4A genes and inhibitors PI3K/AKT pathway. also investigated disruption AKT-NR4A1 signaling endometrium female rats induced...
A series of dinuclear Ir(III) complexes have been constructed for enhanced photodynamic and photothermal therapy (PDT PTT) cisplatin-resistant non-small-cell lung cancer. They enter cells via caveolar endocytosis, target mitochondria but not nuclear, generate both singlet oxygen superoxide anion, release heat when exposed to infrared (IR) irradiation, thus inducing reactive species (ROS)-associated cell disruption thermal ablation. The IR-generated ROS can further activate caspases,...
Mutations or aberrant expression of genes in an organism tend not to be completely random and this cumulative effect predisposes the development malignant tumours. This study aims reveal possible high frequency mutated genes, then investigate their role development, prognosis, signalling pathway function drug resistance breast cancer. The cancer (BRCA) clinical samples were identified detected by high-throughput sequencing. High-frequency mutant counted. Gene profiles relationship with...
<b><i>Objectives:</i></b> The aim of this study was to investigate the effects berberine on polycystic ovary syndrome (PCOS) with insulin resistance (IR). <b><i>Design:</i></b> This performed 16S rRNA sequencing and metabolomic analysis dehydroepiandrosterone (DHEA)-induced PCOS rats treated berberine, focusing improvement PCOS-IR by modifying gut microbiota metabolism. <b><i>Methods:</i></b> Forty-two female Sprague...
Pyroptosis, an inflammatory form of programmed cell death, takes essential part in a wide variety physiological activities, for instance, implantation, placentation and the body's defense against infection. However, once excessively activated, pyroptosis mediated by activation inflammasomes can be highly pathological. It cause autoimmune diseases including obstetrical gynecological diseases, such as endometriosis, gestational diabetes mellitus, insulin resistance polycystic ovary syndrome,...
The incidence and the trend of gynaecological cancers have been suggested to vary by ethnicity geographical regions. Whether type in China is different not fully investigated. In this study, we reported China. Data on 13,518 women with were collected from largest obstetrics gynaecology hospital 2003 2013. included age at diagnosis annual number diagnosed endometrial, ovarian, cervical cancer other cancers. increased almost sixfold 2013 compared that 2003. It was largely due increase newly...
The purpose of this study was to identify promising candidate genes and pathways in polycystic ovary syndrome (PCOS). Microarray dataset GSE345269 obtained from the Gene Expression Omnibus database includes 7 granulosa cell samples PCOS patients, 3 normal samples. Differentially expressed (DEGs) were screened between Pathway enrichment analysis conducted for DEGs using ClueGO CluePedia plugin Cytoscape. A Reactome functional interaction (FI) network built ReactomeFIViz, then modules...