A5082500786- Nanoplatforms for cancer theranostics
- Thyroid Cancer Diagnosis and Treatment
- Kruppel-like factors research
- Ferroptosis and cancer prognosis
- Luminescence and Fluorescent Materials
- Genetic factors in colorectal cancer
- Head and Neck Surgical Oncology
- Epigenetics and DNA Methylation
- Congenital Ear and Nasal Anomalies
- Advanced Nanomaterials in Catalysis
- Photodynamic Therapy Research Studies
- Pituitary Gland Disorders and Treatments
- Porphyrin and Phthalocyanine Chemistry
- Click Chemistry and Applications
- Cervical Cancer and HPV Research
- S100 Proteins and Annexins
- Cancer Genomics and Diagnostics
- Infectious Diseases and Mycology
- Vascular Tumors and Angiosarcomas
- Multiple Myeloma Research and Treatments
- Gastrointestinal Tumor Research and Treatment
- Cancer Diagnosis and Treatment
- Cancer Cells and Metastasis
- Tracheal and airway disorders
- Ocular Disorders and Treatments
Shanghai Pudong New Area Gongli Hospital
2023-2025
Ningxia Medical University
2022-2025
Second Military Medical University
2023-2025
Yunnan University
2022-2025
Ministry of Education of the People's Republic of China
2025
Ruijin Hospital
2024
Soochow University
2024
A planar conjugated ligand functionalized with bithiophene and its Ru(II), Os(II), Ir(III) complexes have been constructed as single-molecule platform for synergistic photodynamic, photothermal, chemotherapy. The significant two-photon absorption at 808 nm remarkable singlet oxygen superoxide anion production in aqueous solution cells when exposed to infrared irradiation. most potent Ru(II) complex Ru7 enters tumor via the rare macropinocytosis, locates both nuclei mitochondria, regulates...
A series of dinuclear Ir(III) complexes have been constructed for enhanced photodynamic and photothermal therapy (PDT PTT) cisplatin-resistant non-small-cell lung cancer. They enter cells via caveolar endocytosis, target mitochondria but not nuclear, generate both singlet oxygen superoxide anion, release heat when exposed to infrared (IR) irradiation, thus inducing reactive species (ROS)-associated cell disruption thermal ablation. The IR-generated ROS can further activate caspases,...
This study explores the presence and clinical significance of Epstein- Barr Virus (EBV) Human Papillomavirus (HPV) in papillary thyroid carcinoma (PTC). EBV HPV are known to contribute various cancers, but their roles cancer development debated. Paraffin-embedded tissue blocks from PTC patients (n=255) who underwent surgery between 2020 2021 were analyzed for DNA using PCR-based methods. Results showed positivity 45.1% cases, significantly higher than benign tumors (35.2%), while was low...
Nasal mucosal epithelial hyperplasia can cause nasal hyperplastic diseases, more studies have confirmed that different subtypes of HPV infection play a significant role in proliferative especially inverted papilloma (NIP). This study aims to elucidate the and mechanism HPV11 subtype regulating hyperplasia. In our previous study, expression NIP was analyzed by Flow-through hybridization gene chip (HybridMax), with highest rate observed for subtype. Therefore, we aimed overexpress HPV11E6/E7...
Four dinuclear osmium complexes have been constructed for antitumor phototherapy. The most potent Os4 has extremely high photothermal conversion capability under irradiation of an 808 nm low-power laser, targets mitochondria in human melanoma cells without nucleus affinity, and acts as therapy agent vitro vivo.
Cancer-associated fibroblasts (CAFs) play an essential role in tumorigenesis and development of cancers. Nevertheless, the specific molecular mechanism Laryngeal squamous cell carcinoma (LSCC) still unknown.CAFs, CPFs NFs were isolated identified from laryngeal cancer, para-laryngeal cancer normal tissues. Immunofluorescent staining, Rt-PCR Western Blot used to detect expression related proteins. Wound healing, migration, invasion animal experiments examine ability movement, metastasis...
Lymphangiogenesis has been reported to play crucial roles in the metastasis of thyroid cancer (THCA), but despite significant research on lymphangiogenesis THCA, precise regulatory mechanism remains unclear.Public databases including Cancer Genome Atlas (TCGA), TIMER, and UALCAN were used analyze visualize expression TET3 AHR correlation between these molecules by TIMER. Additionally, RT-PCR Western Blot performed determine mRNA protein related proteins. Plate colony formation, wound...
Introduction: The objective was to investigate the correlation between Epstein-Barr virus (EBV) and human papillomavirus (HPV) infection in development of benign thyroid lesions. Material methods: 29 cases Hashimoto's thyroiditis (HT), 133 adenoma, 34 HT with adenoma paraffin embedded tissue samples were used for EBV HPV quantitative detection. Results: None carried DNA. In samples, positive rate 55.2% (16/29). 37.6% (50/133). combined 67.6% (23/34). There no clinical features such as age...
Abstract A planar conjugated ligand functionalized with bithiophene and its Ru(II), Os(II), Ir(III) complexes have been constructed as single‐molecule platform for synergistic photodynamic, photothermal, chemotherapy. The significant two‐photon absorption at 808 nm remarkable singlet oxygen superoxide anion production in aqueous solution cells when exposed to infrared irradiation. most potent Ru(II) complex Ru7 enters tumor via the rare macropinocytosis, locates both nuclei mitochondria,...
Hemangiomas are rare and benign tumors originating from the pterygopalatine fossa (PPF). In this study, we report a case of PPF hemangioma in 66-year-old male, for which he underwent surgical resection via anterior nasolacrimal recess after preoperative arteria maxillaris embolization. To enhance our understanding on condition, conducted comprehensive review existing literature disease to discuss its clinical characteristics, differential diagnoses, potential treatment approaches.
<title>Abstract</title> Background Specific molecular mechanisms by which AURKA promoted LSCC metastasis were still unknown. Methods Bioinformatic analysis was performed the relationship between TRIM28 and LSCC. Immunohistochemistry, Co-IP assay, Rt-PCR Western Blot used to examine expression of related molecular. Flow cytometry cell numbers G0/G1 phase. Plate colony formation, wound healing, migration, invasion tail vein injection in nude mice assays applied proliferation, movement, Results...
Thyroid cancer, notably papillary thyroid cancer (PTC), is a global health concern with increasing incidence. Anoikis, regulator of programmed cell death, pivotal in normal physiology and, when dysregulated, can drive progression and metastasis. This study explored the impact anoikis on PTC prognosis. Analyzing data from GEO, TCGA, GeneCards, we identified prognostic signature consisting six anoikis-related genes (ARGs): EZH2, PRKCQ, CD36, INHBB, TDGF1, MMP9. independently predicted patient...
Spindle epithelial tumor with thymus-like differentiation of thyroid (SETTLE) is very rare neoplasm 2 cellular forms, cell and spindle cell, most reported cases have been in young people. An 11-year-old boy presented painless swelling the right neck lasting for more than months. A size measuring approximately 3 × cm was resected, intraoperative frozen pathology suggested a tumor, which confirmed as SETTLE by immunohistochemical staining external hospital consultation. The profile resected...
Abstract Background Mutations in DNA mismatch repair (MMR) genes associated with thyroid carcinoma (TC) have rarely been reported, especially East Asian populations. Methods We examined tumor tissue from a cohort of 241 patients diagnosed TC between 2008 and 2020. MMR proteins were detected using microarray-based immunohistochemistry order to identify MMR-protein-deficient (MMR-D) MMR-protein-intact (MMR-I) tumors. retrospectively summarized the clinicopathologic characteristics MMR-D TC,...
Abstract Background Lymphangiogenesis is an important factor in the invasion and metastasis of thyroid cancer (THCA). The relative researches lymphangiogenesis have always been a hot topic THCA, but its specific regulatory mechanism has not totally clear. Methods Public databases including Cancer Genome Atlas (TCGA), TIMER, GEPIA, UALCAN database were employed to analyze visualize expression prognosis TET3 AHR THCA. GEPIA TIMER used correlation between these molecules. Rt-PCR Western Blot...