A5037230341- Insect Resistance and Genetics
- RNA Research and Splicing
- RNA modifications and cancer
- Insect symbiosis and bacterial influences
- Malaria Research and Control
- ZnO doping and properties
- Advanced Nanomaterials in Catalysis
- Insect Pest Control Strategies
- CRISPR and Genetic Engineering
- Glutathione Transferases and Polymorphisms
- RNA regulation and disease
- Receptor Mechanisms and Signaling
- Multiferroics and related materials
- Bone health and treatments
- Invertebrate Immune Response Mechanisms
- Genomics, phytochemicals, and oxidative stress
- Chromosomal and Genetic Variations
- RNA and protein synthesis mechanisms
- HER2/EGFR in Cancer Research
- Pharmacological Receptor Mechanisms and Effects
- Plant-Microbe Interactions and Immunity
- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- Cancer therapeutics and mechanisms
- 2D Materials and Applications
Yunnan University
2025
Ministry of Education of the People's Republic of China
2025
Henan University
2023-2024
Purdue University West Lafayette
2019
University of Notre Dame
2000-2015
Notre Dame of Dadiangas University
2015
Abstract A field trial of permethrin‐impregnated bednets and curtains was initiated in Western Kenya 1990, a strain Anopheles gambiae showing reduced susceptibility to permethrin colonized from this site 1992. leucine–phenylalanine substitution at position 1014 the voltage‐gated sodium channel is associated with resistance DDT many insect species, including West Africa. We cloned sequenced partial cDNA Kenyan permethrin‐resistant we identified an alternative (leucine serine) same position,...
Resistance to the insecticide DDT in mosquito vectors of malaria has severely hampered efforts control this disease and contributed increase prevalence cases seen recent years. Over 90% 300-500 million annual occur Africa, where major vector is Anopheles gambiae. resistance ZAN/U strain An. gambiae associated with an increased metabolism insecticide, catalysed by members glutathione S-transferase (GST) enzyme family, but molecular mechanism underlying metabolic not known. Genetic crosses...
Heat stress (HS) poses a significant challenge to plant survival, necessitating sophisticated molecular mechanisms maintain cellular homeostasis. Here, we identify SICKLE (SIC) as key modulator of HS responses in Arabidopsis (Arabidopsis thaliana). SIC is required for the sequestration RNA DEBRANCHING ENZYME 1 (DBR1), rate-limiting enzyme lariat intronic (lariRNA) decay, into granules (SGs). The DBR1 by enhances accumulation lariRNAs, branched circular RNAs derived from excised introns...
A series of dinuclear Ir(III) complexes have been constructed for enhanced photodynamic and photothermal therapy (PDT PTT) cisplatin-resistant non-small-cell lung cancer. They enter cells via caveolar endocytosis, target mitochondria but not nuclear, generate both singlet oxygen superoxide anion, release heat when exposed to infrared (IR) irradiation, thus inducing reactive species (ROS)-associated cell disruption thermal ablation. The IR-generated ROS can further activate caspases,...
Abstract Cytochrome P450s are a superfamily of haemoproteins, important in the metabolism endogenous compounds and xenobiotics. As first step to elucidating role this family insecticide resistance malaria mosquito, Anopheles gambiae , we have cloned mapped multiple P450 genes. Sixteen cDNAs encoding full‐length were physically mosquito's polytene chromosomes. Fourteen these encode putative CYP6 proteins two belonging CYP9 class. Eighteen new A. Cyp4 genes identified using degenerate PCR...
We report the ability of a novel combinatorial therapy obtained from nanoparticles hyperstar polymers encompassing drugs to selectively target triple negative breast cancer (TNBC) cell proliferation through STAT3 and topoisomerase-II pathways.
Abstract Programed cell death (PCD) plays fundamental roles in plant development and responses to environmental stresses. Here, we report a protein, SICKLE (SIC), which represses PCD. In Arabidopsis (Arabidopsis thaliana), the loss-of-function mutant of SIC, sic-4, hyperaccumulated lariat intronic RNAs (lariRNAs) exhibited The gene encoding an RNA debranching enzyme 1 (DBR1), rate-limiting for lariRNAs decay, was overexpressed reduce level sic-4 mutant, led suppression Meanwhile, another...
SUMMARY The biogenesis of functional forms chloroplast ribosomal RNAs (rRNAs) is crucial for the translation mRNAs into polypeptides. However, molecular mechanisms underlying proper processing and maturation rRNA species are poorly understood. Through a genetic approach, we isolated characterized an Arabidopsis mutant, α1‐4 , harboring missense mutation in plastid chaperonin‐60α1 gene. Using allelism tests transgenic manipulation, determined redundancy among ptCPN60 subunits. ptCPN60α1 S57F...