A5071336987- Spine and Intervertebral Disc Pathology
- Pain Mechanisms and Treatments
- Preterm Birth and Chorioamnionitis
- Neonatal Respiratory Health Research
- Birth, Development, and Health
- Advanced Proteomics Techniques and Applications
- Pregnancy and preeclampsia studies
- Pregnancy-related medical research
- Musculoskeletal pain and rehabilitation
- Food Security and Health in Diverse Populations
- Spinal Hematomas and Complications
- Gestational Diabetes Research and Management
- Infant Nutrition and Health
University of Gothenburg
2014-2022
Sahlgrenska University Hospital
2020-2022
Institute for Biomedicine
2019
During recent decades, the knowledge of pathophysiology disc herniation and sciatica has drastically improved. What previously was considered a strict biomechanical process is now more complex interaction between leaked nucleus pulposus tissue in spinal canal. An inflammatory reaction, with tumor necrosis factor (TNF) playing an essential role, been demonstrated. However, exact mechanisms remain unknown.In this study we use animal model to investigate (1) if and/or how experimental affects...
Background Amniotic fluid is clinically accessible via amniocentesis and its protein composition may correspond to birth timing. Early changes in the amniotic proteome could therefore be associated with subsequent development of spontaneous preterm delivery. Objective The main objective this study was perform unbiased proteomics analysis association between mid-trimester delivery gestational duration, respectively. A secondary validate replicate findings by enzyme-linked immunosorbent assay...
To evaluate the concentrations of calprotectin in amniotic fluid with respect to intra-amniotic inflammation and infection assess presence or absence bacteria amnio-chorionic niche inflammation.Seventy-nine women singleton pregnancies preterm labor intact membranes (PTL) were included study. Amniotic was collected at time admission by amniocentesis levels analyzed from frozen/thawed samples using ELISA. Interleukin (IL)-6 concentration measured point-of-care test. Samples (space between...
A disc herniation has traditionally been considered as tissue that slipped out from an intervertebral disc. However, it was recently suggested the mass is a product of bioactive substances and hernia would more likely be scar than herniated material. In this study, we aimed to analyze structural components experimentally induced herniations compare with nucleus pulposus, in rat.Twenty-eight rats had their L4-5 discs punctured. After three weeks, nodule formed over puncture site, spine...