A5101714747- Crystal structures of chemical compounds
- Metal complexes synthesis and properties
- Metal-Organic Frameworks: Synthesis and Applications
- Lanthanide and Transition Metal Complexes
- Crystallography and molecular interactions
- Magnetism in coordination complexes
- Prostate Cancer Treatment and Research
- Polyoxometalates: Synthesis and Applications
- Cancer, Hypoxia, and Metabolism
- Cancer Genomics and Diagnostics
- Enzyme Structure and Function
- Congenital Anomalies and Fetal Surgery
- Synthesis and Characterization of Heterocyclic Compounds
- Organometallic Compounds Synthesis and Characterization
- Ultrasound and Hyperthermia Applications
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Dermatology and Skin Diseases
- Dermatologic Treatments and Research
- Pancreatic and Hepatic Oncology Research
- Metal-Catalyzed Oxygenation Mechanisms
- Signaling Pathways in Disease
- Cancer-related gene regulation
- Nail Diseases and Treatments
- Molecular Sensors and Ion Detection
- Cloud Computing and Resource Management
Kunming Medical University
2025
First Affiliated Hospital of Kunming Medical University
2025
Shihezi University
2024
Shandong Provincial Institute of Dermatology and Venereology
2024
Shandong Provincial Hospital
2024
Shandong First Medical University
2024
Qilu Hospital of Shandong University
2024
University of Hawaiʻi at Mānoa
2023
University of Hawaii Cancer Center
2023
University of Hawaii System
2023
Earlier studies reported allelic deletion of the essential autophagy regulator BECN1 in breast cancers implicating loss, and likely defective autophagy, tumorigenesis. Recent have questioned tumor suppressive role as autophagy-related gene (Atg) defects generally suppress tumorigenesis well-characterized mouse models. We now report that, while it delays or does not alter mammary driven by Palb2 loss ERBB2 PyMT overexpression, monoallelic Becn1 promotes development 2 specific contexts, namely...
Highlights•GLUL expression is high in human pancreatic cancers and mouse PDAC models•aKG rescue of glutamine-deprived cells requires GLUL•De novo glutamine synthesis essential for nitrogen anabolic processes•Genetic ablation GLUL suppresses developmentSummaryGlutamine thought to play an important role cancer by being deaminated via glutaminolysis α-ketoglutarate (aKG) fuel the tricarboxylic acid (TCA) cycle. Supporting this notion, aKG supplementation can restore growth/survival cells....
The class III phosphoinositide 3-kinase (PI3K) Vps34 (also known as PIK3C3 in mammals) produces phosphatidylinositol 3-phosphate [PI(3)P] on both early and late endosome membranes to control membrane dynamics. We used Vps34-deficient cells delineate whether has additional roles endocytic trafficking. In Vps34-/- mouse embryonic fibroblasts (MEFs), transferrin recycling EEA1 localization were unaffected despite elevated Rab5-GTP levels. Strikingly, a large increase Rab7-GTP levels, an...
Abstract BACKGROUND Prostate tumor‐initiating cells (TICs) have intrinsic resistance to current therapies. TICs are commonly isolated by cell sorting or dye exclusion, however, isolating from limited primary prostate cancer (PCa) tissues is inherently inefficient. We adapted the collagen adherence feature develop a combined immunophenotypic and time‐of‐adherence assay identify human TICs. METHODS PCa multiple lines were allowed adhere several matrix molecules, fractions of adherent examined...
Current prostate cancer management calls for identifying novel and more effective therapies. Self-renewing tumor-initiating cells (TICs) hold intrinsic therapy resistance account tumor relapse progression. As BMI-1 regulates stem cell self-renewal, impairing function TIC-tailored therapies appears to be a promising approach.We have previously developed combined immunophenotypic time-of-adherence assay identify CD49bhiCD29hiCD44hi as human TICs. We utilized this with patient-derived xenograft...
The development of digital imaging technology is creating extraordinary levels accuracy that provide support for improved reliability in different aspects the image analysis, such as content-based retrieval, segmentation, and classification. This has dramatically increased volume rate at which data are generated. Together these facts make querying sharing non-trivial render centralized solutions unfeasible. Moreover, many cases this often distributed must be shared across multiple...
Gleason-grading of prostate cancer pathology specimens reveal the malignancy tissues, thus provides critical guidance for diagnoses and treatment. Computer-aided automatic grading methods have been providing efficient result-consistent alternative to traditional manually slide reading approach, through statistical structural feature analysis digitized slides. In this paper, we propose a novel Gleason algorithm local structure model learning classification. We use attributed graph represent...
To examine histopathologic features and clinical outcomes of intradiverticular bladder carcinomas. Twenty-two consecutive patients with carcinoma treated either endoscopic transurethral resection or partial radical cystectomy at a single institution between years 1995 to 2011. Clinicopathologic characteristics oncologic were retrospectively analyzed, including tissue histology re-review by genitourinary pathologists. Histologically, 9 cases (41%) non-invasive papillary urothelial carcinoma,...
摘要: 患儿男,3岁1个月,因头皮黄红色皮疹1个月就诊于山东大学齐鲁医院。患儿1个月前无明显诱因头皮出现黄红色皮疹,皮疹遇热或摩擦后增多。患儿足月生产,出生时身高体重正常。个人史及家族史无特殊……
Background and objective: A variety of laser IPL treatments with continued progress have been applied for nonablative skin rejuvenation; however, the complete understanding working mechanisms clinical appliance strategy is not clear. Materials methods: The rats were divided into three groups irradiated Q-switched 1064 nm Nd:YAG IPL. Image analysis, chemical colorimetry method, real-time PCR (RT-PCR) used to detect dermal thickness, hydroxyproline, expression III procollagen mRNA,...
Biomarkers predicting tumor response are important to emerging targeted therapeutics. Complimentary methods assess and understand genetic changes heterogeneity within only few cancer cells in tissue will be a valuable addition for assessment of tumors such as prostate that often have insufficient next generation sequencing single biopsy core.Using confocal microscopy identify cell-to-cell relationships situ, we studied the most common gene rearrangement (TMPRSS2 ERG) suppressor CHD1 56...
Nine patients with recrudescent and centrifugally expanded papuloerythematous eruptions were observed in our outpatient department during the recent 8 years. The all young middle-aged men presenting characteristic skin lesions relapsing each year warm humid season. Such an observation has not yet been described English literature.The objective of this study was to describe clinical characteristics explore possible etiologies cases. In addition, differential diagnosis other common figurate...
Lung adenocarcinoma (LUAD) is the major subtype in lung cancer, and cigarette smoking essentially linked to its pathogenesis. We show that downregulation of Filamin A interacting protein 1-like (FILIP1L) a driver LUAD progression. Cigarette causes by promoter methylation LUAD. Loss FILIP1L increases xenograft growth, and, lung-specific knockout mice, induces adenoma formation mucin secretion. In syngeneic allograft tumors, reduction subsequent increase binding partner, prefoldin 1 (PFDN1)...
Cloud computing has emerged as a new paradigm for the delivery of resources. It brings great opportunities to software testing, especially load testing. In this paper, we focus on migrating conventional testing tools cloud, which two significant issues are about multi-tenancy and simulating resource management. We propose four layer model cloud-based along with approach test request admission control scheduling solve these issues. carried out concrete case study our proposed made efficiency...
Two cases of adrenocortical heterotopia are reported. One is in a full-term placenta. The other adjacent to the ovarian hilum an adult. Both incidental findings. Despite sharing similar histological and immunological features, they show different growth patterns. literature reviewed heterotopias locations compared. New hypotheses its histogenesis discussed.
Abstract Hypoxia‐inducible factor 1 α ( HIF ‐1 ) is the regulatory subunit of heterodimeric that plays a critical role in transcriptional regulation genes angiogenesis and hypoxic adaptation, while fatty acid metabolism mediated by lipoxygenases has been implicated variety pathogeneses, including cancers. In this study, we report 15‐lipoxygenase (15‐ LO 1), key member lipoxygenase family, promotes ubiquitination degradation. Altering level 15‐ yields inverse changes activity, under both...