A5035035559- Luminescence and Fluorescent Materials
- Molecular Sensors and Ion Detection
- Analytical Chemistry and Sensors
- Conducting polymers and applications
- Organic Light-Emitting Diodes Research
- Nanoplatforms for cancer theranostics
- X-ray Diffraction in Crystallography
- Wound Healing and Treatments
- Microbial bioremediation and biosurfactants
- Bacterial biofilms and quorum sensing
- Photochemistry and Electron Transfer Studies
- Liquid Crystal Research Advancements
- Crystallization and Solubility Studies
- biodegradable polymer synthesis and properties
- Carbon dioxide utilization in catalysis
- Material Dynamics and Properties
- Mass Spectrometry Techniques and Applications
- Photochromic and Fluorescence Chemistry
- Gas Sensing Nanomaterials and Sensors
- Jewish and Middle Eastern Studies
- Intelligence, Security, War Strategy
- Angiogenesis and VEGF in Cancer
- Boron and Carbon Nanomaterials Research
- Nonlinear Optical Materials Research
- Hemoglobin structure and function
University of Virginia
2014-2022
University of Minnesota
2020-2021
McCormick (United States)
2014-2020
Charlottesville Medical Research
2016-2020
Office of the Chief Medical Examiner
2020
University of Minnesota System
2020
West Virginia Wesleyan College
2018
Rutgers Sexual and Reproductive Health and Rights
2003
Dual emissive properties of solid-state difluoroboron β-diketonate-poly(lactic acid) (BF2bdk-PLA) materials have been utilized as biological oxygen sensors. Dyes with red-shifted absorption and emission are important for multiplexing in vivo imaging, thus hydroxyl-functionalized dinaphthoylmethane initiators dye-PLA conjugates BF2dnm(X)PLA (X = H, Br, I) extended conjugation were synthesized. The luminescent show absorbance (∼435 nm) fluorescence tunability by molecular weight. Fluorescence...
Difluoroboron β-diketonate poly(lactic acid) materials exhibit both fluorescence (F) and oxygen sensitive room-temperature phosphorescence (RTP). Introduction of halide heavy atoms (Br I) is an effective strategy to control the sensitivity in these materials. A series naphthyl-phenyl (nbm) dye derivatives with hydrogen, bromide, iodide substituents were prepared for comparison. As nanoparticles, hydrogen derivative was hypersensitive (0–0.3%), while bromide analogue suited hypoxia detection...
Capable of mediating efficient transfection and protein production without eliciting innate immune responses, chemically modified mRNA holds great potential to produce paracrine factors at a physiologically beneficial level, in spatiotemporally controlled manner, with low toxicity. Although highly promising cardiovascular medicine wound healing, effects this emerging therapeutic on the microvasculature its bioactivity disease settings remain poorly understood. Here, we longitudinally...
Luminescent materials are important for imaging and sensing. Aromatic difluoroboron β-diketonate complexes (BF2bdks) classic fluorescent molecules that have been explored as photochemical reagents, two-photon dyes, oxygen sensors. A series of BF2bdks with naphthyl phenyl groups was synthesized, photophysical properties were investigated in both methylene chloride poly(lactic acid) (PLA). Polymer molecular weight dye attachment site along bromide heavy atom placement varied to tune optical...
The dual-emissive properties of solid-state difluoroboron β-diketonate-poly(lactic acid) (BF2bdkPLA) materials have been utilized for biological oxygen sensing. In this work, BF2dbm(X)PLA were synthesized, where X = H, F, Cl, Br, and I. effects changing the halide substituent PLA polymer chain length on optical in dilute CH2Cl2 solutions films studied. These luminescent show fluorescence, phosphorescence, lifetime tunability basis molecular weight, as well modulation via substituent. Short...
Lifetime-based oxygen imaging is useful in many biological applications but instrumentation can be stationary, expensive, and complex. Herein, we present a portable, cost effective, simple alternative with high spatiotemporal resolution that uses complementary metal oxide silicon (CMOS) camera to measure sensitive lifetimes on the millisecond scale. We demonstrate its compatibility difluoroboron β-diketonate poly(lactic acid) (BF2bdkPLA) polymers which are nontoxic exhibit long-lived...
The optical properties of meta-alkoxy-substituted difluoroboron dibenzoylmethane dyes were investigated in solution and the solid state. Meta-alkoxy substitution induced strong intramolecular charge transfer (ICT) from oxygen-donating substituent to halide boron acceptors excited state, as compared π–π* transition that is observed with para-alkoxy substitution. para- meta-substituted alkoxy evaluated by calculations, dilute solution, solid-state films. When embedded amorphous matrixes (e.g.,...
Multi-stimuli responsive properties were found for azepane-substituted β-diketones and difluoroboron complexes, including solvatochromism, viscochromism, aggregation-induced emission, mechanochromic luminescence halochromism.
Difluoroboron β-diketonate compounds exhibit solid-state luminescence phenomena. Among these are reversible mechanochromic (ML), aggregation induced emission (AIE), and quenching (MLQ). These properties can be tuned by alterations to the molecular structure. Dyes with varying halide substituents tunable ML, MLQ, high quantum yields. A series of difluoroboron dibenzoylmethane (BF2dbm) dyes iodide alkoxyl (BF2dbm(I)OR) were synthesized where R = CH3 (C1), C5H11 (C5), C6H13 (C6), C12H25 (C12),...
Difluoroboron β-diketonates (BF2 bdks) show both fluorescence (F) and room-temperature phosphorescence (RTP) when confined to a rigid matrix, such as poly(lactic acid). These materials have been utilized optical oxygen sensors (e.g., in tumors, wounds, cells). Spectral features include charge transfer (CT) from the major aromatic donor dioxaborine acceptor. A series of naphthyl-phenyl dyes nbm) (1-6) were prepared test heavy-atom placement effects. The BF2 nbm dye (1) was substituted with Br...
Optical properties of biphenyl difluoroboron β-diketonates were studied in poly(lactic acid) (PLA) blends.
Luminescent difluoroboron β-diketonate poly(lactic acid) (BF2bdkPLA) materials serve as biological imaging agents. In this study, dye structures were modified to achieve emission colors that span the visible region with potential for multiplexing applications. Four dyes varying π-conjugation (phenyl, naphthyl) and donor groups (−OMe, −NMe2) coupled PLLA–PEG block copolymers (∼11 kDa) by a postpolymerization Mitsunobu reaction. The resulting dye–polymer conjugates fabricated nanoparticles...
Difluoroboron β-diketonate-polylactides are versatile oxygen-sensing materials. These materials have both fluorescence (F) and oxygen-sensitive, room-temperature phosphorescence (RTP). The fluorescence, being insensitive to oxygen, can act as an internal standard the changing phosphorescence, ratiometric sensing of oxygen be achieved with these simple, single-component To expand range colors for this family fluorophores, a series thienyl-phenyl-substituted dyes were synthesized initiator...
Difluoroboron β-diketonate materials are used for biomedical oxygen-sensing applications. These fluorophores show both fluorescence (F) and phosphorescence (P) when the dye is embedded in a polymer matrix. The insensitive to oxygen quenching, while changes intensity depending on concentration. This enables quantification by ratiometric methods with good spatial temporal resolution. Here, we produce ratiometric-capable sensors without need of heavy atom. achieved substituting methoxyl groups...
Difluoroboron β-diketonates have impressive optical properties in both solution and the solid state. In particular, fluorescence room-temperature phosphorescence are present when dyes confined to a rigid matrix, such as poly(lactic acid) (PLA). To expand current knowledge color range capabilities of this unique type multi-emitting chromophore, series thienyl-substituted BF2bdk complexes been synthesized. The photophysical were investigated methylene chloride state dye/PLA blends. By varying...
Oxygen is essential to wound healing; therefore, accurate monitoring can guide clinical decisions. Clinical assessment often subjective, and tools monitor oxygen are typically expensive, indirect, highly variable. This study demonstrates the utility of a novel, low-cost oxygen-sensing thin film for serial oxygenation.Dual-layer films were fabricated with boron nanoparticles (BNPs) impregnated into chitosan-polycaprolactone layer direct bed contact relatively impermeable calcium alginate...
Shear-induced crystallization of dyes in the amorphous state is an effective strategy for generating higher energy emission after mechanical perturbation—a rare phenomenon mechanoresponsive materials. Recently, we reported that a β-diketone with 3,4,5-trimethoxy-substituted phenyl ring formed stable supercooled liquid (SCL) phase melting and cooling air. To tune lifetime β-diketones SCL phase, series rings were synthesized. Derivatives naphthyl prepared order to modulate through arene...
We present the synthesis and characterization of polymers containing 1,3-butanediol, also known as butylene glycol. Butylene glycol (BG) can be prepared from petroleum or sugar-based feedstocks. Petrol-based BG (petrol-BG) is isolated a racemic mixture, whereas biobased sugar that we utilized (bio-BG) enantiopure upon purification (>99.7%). In presence titanium catalyst, polyesters were by transesterification polymerization between petrol- bio-BG various aliphatic aromatic diacid...
We present (R)-1,3-butylene carbonate (R-BC) as a biorenewable monomer for the preparation of semicrystalline aliphatic polycarbonates. This conversion is achieved by using enantiomerically pure, biobased (R)-(−)-1,3-butanediol (bio-BG) renewable feedstock. Ring-opening polymerization from select catalysts at low temperatures can yield regioregular poly((R)-1,3-butylene carbonate) (R-PBC) with properties (Xreg = > 0.99; Tm 72 °C). Along R-enantiomeric polymer, alternate stereochemical...
Abstract Difluoroboron β‐diketonates (BF 2 bdks) exhibit fluorescence (F) and room‐temperature phosphorescence (RTP) in a poly(lactic acid) (PLA) matrix. Fluorescence color tuning has been achieved by dye loading or bdk ligand modification, namely substituent effects extended conjugation. In this study, color‐tunable RTP (450–570 nm) is with 1‐benzoylacetonate derivatives varying the number position of methoxy groups on benzene ring. The can be used to alter energy levels induce geometry...
Using nanoparticles with a bright boron-based fluorescent dye in the core allows for cell tracking across multiple short wavelength excitation sources.
Significance: Decreasing the oxygen consumption rate (OCR) of tumor cells is a powerful method for ameliorating hypoxia. However, quantifying change in OCR challenging complex experimental systems. Aim: We present two cell lines using oxygen-sensitive dual-emissive boron nanoparticles (BNPs). hypothesize that our BNP results are equivalent to standard Seahorse assay. Approach: quantified spectral emissions and accounted external diffusion quantify over 24 h. The BNP-computed breast cancer...
Luminescent β-diketones (bdks) and difluoroboron coordinated complexes (BF2bdks) exhibit many environment-sensitive properties, such as solvatochromism, viscochromism, aggregation-induced emission (AIE), thermal mechanochromic luminescence (ML). In a previous study, an azepane-substituted bdk ligand (L1) boron dye (D1) showed noteworthy properties but low quantum yields (Φ, L1: 0.26; D1: 0.02) due to free intramolecular bond rotation twisted charge transfer state formation with associated...