A5055748578- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Autophagy in Disease and Therapy
- Memory and Neural Mechanisms
- Neonatal and fetal brain pathology
- Mitochondrial Function and Pathology
- Gastrointestinal motility and disorders
- Molecular Sensors and Ion Detection
- ATP Synthase and ATPases Research
- Ion channel regulation and function
- Antioxidants, Aging, Portulaca oleracea
- Cardiac electrophysiology and arrhythmias
- Electrospun Nanofibers in Biomedical Applications
- Coronary Interventions and Diagnostics
- Anesthesia and Neurotoxicity Research
- Parkinson's Disease Mechanisms and Treatments
- Neurological Disease Mechanisms and Treatments
- Olfactory and Sensory Function Studies
- Sleep and Wakefulness Research
- Stress Responses and Cortisol
- Dysphagia Assessment and Management
- Polymer Surface Interaction Studies
- Medicinal Plants and Bioactive Compounds
Guangzhou University of Chinese Medicine
2019-2023
Guangzhou University
2021
South China Normal University
2016-2019
China Association of Acupuncture-Moxibustion
2019
Alzheimer disease (AD) is the most prevalent neurodegenerative disorder leading to dementia in elderly. Unfortunately, no cure for AD available date. Increasing evidence has proved roles of misfolded protein aggregation due impairment macroautophagy/autophagy-lysosomal pathway (ALP) pathogenesis AD, and thus making TFEB (transcription factor EB), which orchestrates ALP, as a promising target treating AD. As complementary therapy, acupuncture or electroacupuncture (EA) been commonly used...
Amyloid precursor protein (APP) is enriched at the synapse, but its synaptic function still poorly understood. We previously showed that GABAergic short-term plasticity impaired in App knock-out (App-/-) animals, precise mechanism by which APP regulates transmission has remained elusive. Using electrophysiological, biochemical, moleculobiological, and pharmacological analysis, here we show can physically interact with KCC2, a neuron-specific K+-Cl- cotransporter essential for Cl- homeostasis...
Abstract Background Before the deposition of amyloid-beta plaques and onset learning memory deficits, patients with Alzheimer’s disease (AD) experience olfactory dysfunction, typified by a reduced ability to detect, discriminate, identify odors. Rodent models AD, such as Tg2576 APP/PS1 mice, also display impaired olfaction, accompanied aberrant in vivo or vitro gamma rhythms pathway. However, mechanistic relationships between electrophysiological, biochemical behavioral phenomena remain...
Neuroinflammation with excess microglial activation and synaptic dysfunction are early symptoms of most neurological diseases. However, how microglia-associated neuroinflammation regulates activity remains obscure. We report here that acute induced by intraperitoneal injection lipopolysaccharide (LPS) results in cell-type-specific increases inhibitory postsynaptic currents the glutamatergic, but not GABAergic, neurons medial prefrontal cortex (mPFC), coinciding excessive activation. LPS...
Abstract Background The impairment in the autophagy-lysosomal pathway (ALP) and activation of NLR family pyrin domain containing 3 (NLRP3) inflammasome represent two molecular events leading to neurodegeneration neuroinflammation Alzheimer’s disease (AD), a devastating neurodegenerative disorder without cure. Previously we demonstrated cognitive-enhancing effect combined electroacupuncture (EA) therapy termed TNEA transgenic mouse model AD, involving transcription factor EB (TFEB), master...
Alzheimer's disease (AD) is the most common neurodegenerative disorder worldwide. Mitochondrial dysfunction thought to be an early event in onset and progression of AD; however, precise underlying mechanisms remain unclear. In this study, we investigated mitochondrial proteins involved organelle dynamics, morphology energy production medial prefrontal cortex (mPFC) hippocampus (HIPP) young (1∼2 months), adult (4∼5 months) aged (9∼10, 12∼18 APP/PS1 mice. We observed increased levels fission...
Genetic and biochemical studies have focused on the role of amyloid β protein in pathogenesis Alzheimer's disease. In comparison, physiological roles its precursor protein, (APP), synaptic network activity is less well studied. Using an APP knockout (APP−/−) mouse model, we show that duration UP state, which a key feature cortical integration occurring predominantly during slow-wave sleep, significantly increased prefrontal cortex (PFC) absence APP. This was accompanied by specific reduction...
To investigate the effects on motor function, cortex blood flow perfusion, microglial cells, and contents of serum inflammatory factors, i.e. interleukin-1β (IL-1β), transforming growth factor-β (TGF-β), interleukin-10 (IL-10) after electroacupuncture (EA) preconditioning at "Baihui" (GV20) "Dazhui" (GV14) in mice with ischemic stroke, so as to explore mechanism EA for improving function stroke.C57BL/6 were randomly divided into sham-operation group, model group (EA group), 15 each group. A...
Vascular stent interventional therapy is the main method for clinical treatment of coronary artery diseases. However, due to insufficient biocompatibility cardiovascular materials, implantation stents often leads serious adverse cardiac events. Surface biofunctional modification improve vascular has been focus current research. In this study, based on structure and function extracellular matrix injury healing, a novel fibronectin-loaded poly-l-lysine/heparin nanoparticles was constructed...
Neonatal seizures are different from adult seizures, and many antiepileptic drugs that effective in adults often fail to treat neonates. Here, we report gluconate inhibits neonatal seizure by inhibiting CLC-3 chloride channels. We detect a voltage-dependent outward rectifying Cl− current mediated channels early developing brains but not mouse brains. Blocking activity both brain slices animals with vivo EEG recordings. Consistently, neurons of knockout mice lack the show reduced epileptiform...
Background: Neuropathological features of Alzheimer’s disease are characterized by the deposition amyloid-β (Aβ) plaques and impairments in synaptic activity memory. However, we know little about physiological role protein precursor (AβPP) from which Aβ derives. Objective: Evaluate APP deficiency induced alterations neuronal electrical mitochondrial expression. Methods: Utilizing electrophysiological, biochemical, pharmacological, behavioral tests, revealed aberrant local field potential...
Abstract Neuroinflammation and synaptic dysfunction are two early symptoms of most neurological diseases. However, the mechanisms underlying microglia-associated neuroinflammation in regulation activity remain obscure. We report here that acute induced by a single-dose proinflammatory cytokine inducer, lipopolysaccharide (LPS), results enhanced inhibitory postsynaptic currents (IPSCs) glutamatergic neurons, upregulated levels GABA A R subunits, glutamine synthetase (GS) vGAT, downregulated...
Constipation is the most predominant symptom of Parkinson disease (PD), preceding occurrence motor symptoms in some patients, leading to reduced quality life (QOL). The general approaches for treatment have side effects, but probiotics are live or attenuated microorganisms attributed ameliorating constipation effects. Moreover, as treatments generally well tolerated and effects scarce, there room further research. Therefore this work aims at investigating clinical effectiveness safety...
EEG is a useful method to detect electrical activity in the brain. Moreover, it widely used diagnostic tool for various neurological conditions, such as epilepsy and neurodegenerative disorders. However, technically difficult obtain recordings neonates requires specialized handling great care. Here, we present novel record neonatal rat pups (P8-P15). We designed simple reliable electrode using computer pin loci; can be easily implanted into skull of pup high-quality signals normal epileptic...
EEG is a useful method to detect electrical activity in the brain. Moreover, it widely used diagnostic tool for various neurological conditions, such as epilepsy and neurodegenerative disorders. However, technically difficult obtain recordings neonates requires specialized handling great care. Here, we present novel record neonatal rat pups (P8-P15). We designed simple reliable electrode using computer pin loci; can be easily implanted into skull of pup high-quality signals normal epileptic...