Design of dual mode or multimode contrast agents nanoplatforms with antifouling properties is crucial for improved cancer diagnosis since the materials are able to escape clearance reticuloendothelial system pharmacokinetics. Herein, we present creation zwitterionic gadolinium(III) (Gd(III))-complexed dendrimer-entrapped gold nanoparticles (Au DEN) enhanced computed tomography (CT)/magnetic resonance (MR) imaging lung metastasis. In work, poly(amidoamine) (PAMAM) dendrimers generation 5 were...

Chlorotoxin-conjugated multifunctional dendrimers labeled with radionuclide 131I were synthesized and utilized for targeted single photon emission computed tomography (SPECT) imaging radiotherapy of cancer. In this study, generation five amine-terminated poly(amidoamine) used as a platform to be sequentially conjugated polyethylene glycol (PEG), targeting agent chlorotoxin (CTX), 3-(4'-hydroxyphenyl)propionic acid-OSu (HPAO). This was followed by acetylation the remaining dendrimer terminal...

Novel theranostic nanocarriers exhibit a desirable potential to treat diseases based on their ability achieve targeted therapy while allowing for real-time imaging of the disease site. Development such platforms is still quite challenging. Herein, we present construction multifunctional dendrimer-based nanosystem cancer cell chemotherapy and computed tomography (CT) with targeting specificity. Doxorubicin (DOX), model anticancer drug, was first covalently linked onto partially acetylated...

The lack of sensitivity and poor matrix tolerance are the main bottlenecks lateral flow immunoassay (LFIA). Here, a sensitive matrix-tolerant method that integrated immunomagnetic separation fluorescent (IMS–FLFIA) based on magnetic nanobeads was developed to detect clenbuterol (CLE) residue in swine urine. limit detection (LOD) IMS–FLFIA is 4 times lower than traditional colloidal gold LFIA. This method, which exhibits similar LOD linearity range both phosphate-buffered saline urine swine,...

A Mn3O4 nanoparticle (NP)-based dual-modality probe has been developed for tumor positron emission tomography (PET)/magnetic resonance (MR) imaging. The imaging was constructed by modifying multifunctional polyethyleneimine (PEI)-coated NPs with folic acid (FA), followed the radiolabeling 64Cu. formed utilized PET/MR of human cervical cancer mouse xenografts, which overexpress folate receptor (FR). PEI-coated were synthesized using a solvothermal approach via decomposition acetylacetone...

Multifunctional gadolinium-loaded dendrimer nanocomplexes can be used to encapsulate doxorubicin for targeted magnetic resonance imaging and chemotherapy of cancer cells.

The combination of photothermal therapy (PTT) and photodynamic (PDT) in cancer treatment has attracted much attention recent years. However, developing highly efficient targeted therapeutic nanoagents for amplifying PTT PDT treatments remains challenging. In this work, we developed a novel nanoplatform cells overexpressing integrin αvβ3 through the coating polydopamine (PDA) on indocyanine green (ICG)-loaded laponite (LAP) then further conjugating polyethylene...

The development of functional intelligent theranostic nanoplatform for imaging-directed synchronous inhibition primary tumor and metastasis is still a challenging task. We present here the creation dendrimer-entrapped CuS nanoparticles (CuS DENPs) complexed with plasmid DNA-encoding hypermethylation in cancer 1 (pDNA-HIC1) photoacoustic (PA) simultaneous tumors metastasis. Poly(amidoamine) dendrimers generation 5 were covalently attached 1,3-propane sultone arginine-glycine-aspartic acid...

Background Helicobacter pylori ( H. ) eradication has been reported to cause short-term disruption of gut microbiota. It is acknowledged that probiotics supplementation mitigates side effects induced by eradication, yet its role on alleviating dysbiosis microbiota obscure. Objectives To evaluate the impact gastrointestinal after therapy. Methods This was a multicenter, double-blinded, randomized trial done at seven centers in China. A total 276 treatment-naïve -positive patients were...

Multifunctional folic acid-modified dendrimers can be labeled with radioactive ¹³¹I for targeted SPECT imaging and radiotherapy of tumors.

Zwitterion-modified dendrimer-entrapped gold nanoparticles having improved antifouling properties can be used for enhanced blood pool, lymph node, and tumor CT imaging.

Non-invasive imaging of apoptosis in tumors induced by chemotherapy is great value the evaluation therapeutic efficiency. In this study, we report synthesis, characterization, and utilization radionuclide technetium-99m (99mTc)-labeled dendrimer-entrapped gold nanoparticles (Au DENPs) for targeted SPECT/CT chemotherapy-induced tumor apoptosis. Generation five poly(amidoamine) (PAMAM) dendrimers (G5.NH2) were sequentially conjugated with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic...

The poly(amidoamine) dendrimers modified with Buthus martensii Karsch chlorotoxin (BmK CT) were developed as a (131)I delivery system for glioma-targeted imaging and therapy.Dendrimers before after labeling synthetized their physicochemical properties tested. targeting therapeutic efficacy of (131)I-G5.NHAc-HPAO-(PEG-BmK CT)-(mPEG) dendrimer against glioma was evaluated in vitro vivo.All the stable under different conditions. BmK CT modification increased cellular uptake C6 cells, but not...

Silver nanoprism-based plasmonic ELISA for qualitative and quantitative detection of fluoroquinolones.

Abstract Design of stimuli‐responsive nanomedicine with enhanced tumor delivery for combination therapy still remains a great challenge. Here, unique design an antifouling‐dendrimer‐based nanoplatform dual pH‐ and redox‐responsiveness is reported to meet this First, generation 5 (G5) poly(amidoamine) dendrimers are modified targeting ligand cyclic arginine–glycine–aspartic acid (RGD) peptide through polyethylene glycol (PEG) spacer zwitterion thiolated N , ‐dimethyl‐cysteamine‐carboxybetaine...

We report the design of fourth generation poly(propylene imine) (PPI) glycodendrimers for magnetic resonance (MR) imaging applications. The were designed to have a densely organized maltose shell (MAL DS) and several tetraazacyclododecane tetraacetic acid (DOTA) ligands that attached periphery PPI dendrimers Gd(iii) chelation. show formed MAL DS-modified possess good cytocompatibility hemocompatibility in studied concentration range. With longitudinal relaxivity (r1) PPI-MAL DS-DOTA(Gd)...

The development of gene vectors is the vital step in therapy. cationic polymer polyethylenimine (PEI) widely applied as an efficient and low cost nonviral vehicle. However, its further practical applications therapy are limited due to high cytotoxicity. To obtain safe vectors, hydrophilic polyethylene glycol (PEG) has been conjugated onto surface good biocompatibility, PEGylated PEI was used a template entrap gold nanoparticles (Au NPs) with different Au atom/PEI molar ratios (25:1, 50:1,...

Abstract Background & Aims The eradication rate of Helicobacter pylori ( H ) has decreased largely because the antibiotic resistance. We aimed to evaluate effectiveness and safety furazolidone‐containing quadruple regimens for eradication. Methods This was an observational study infection in real‐world settings. Data sets were collected from medical records telephone interviews patients referred a specialist clinic suspected reinfection January 1, 2015, 2018, at First Affiliated Hospital...

Infection caused by carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) has become a tricky health care threat in China and KPC-2 enzyme is main factor mediating resistance to carbapenems of K. . Here, we report the characterization genetic environment blaKPC-2 gene CR-hvKP clinical isolates from South China. Forty-five non-duplicated collected Jiangxi Province 2018 2019 were analyzed. Each them multidrug-resistant due presence not only but also other determinants, including...