The purpose of this study was to identify the functional anatomy mechanisms involved in visually guided prehension and object recognition humans. cerebral blood flow seven subjects investigated by positron emission tomography. Three conditions were performed using same set stimuli. In 'grasping' condition, instructed accurately grasp objects. 'matching' requested compare shape presented with that previous one. 'pointing' condition (control), pointed towards comparison between grasping...

<b><i>Objective:</i></b> To investigate cerebral activity associated with allodynia in patients neuropathic pain. <b><i>Methods:</i></b> The brain responses of 27 peripheral (5), spinal (3), brainstem (4), thalamic lenticular or cortical (5) lesions were studied fMRI as innocuous mechanical stimuli addressed to either the allodynic territory homologous contralateral region. <b><i>Results:</i></b> When applied normal side, brush and cold rubbing did not evoke pain activated a somatosensory...

The human insula is implicated in numerous functions. More and more neuroimaging studies focus on this region, however no atlas offers a complete subdivision of the reference space. aims study were to define protocol subdivide insula, create probability maps MNI152 stereotaxic space, provide normative volume measurements for these subdivisions. Six regions manually delineated bilaterally 3D T1 MR images 30 healthy subjects: three short gyri, anterior inferior cortex, two long gyri. insular...

Previous brain imaging studies have shown robust activations in the insula during nociceptive stimulation. Most involve posterior insular cortex but they can cover all gyri some fMRI studies. However, little is known about timing of across different sub-regions. We report on distribution intracerebrally recorded laser evoked potentials (LEPs) acquired from full extent 44 epileptic patients. Our study shows that both and anterior subdivisions respond to a heat stimulus within 200-400 ms...

The thalamic medial pulvinar nucleus (PuM) is fully developed only in primates and reaches its greatest extent humans. To assess the reciprocal functional connectivity between PuM cortex, we studied intracerebral-evoked responses obtained after cortical electrical stimulation 7 epileptic patients undergoing depth electroencephalographic recordings. Cortical-evoked potentials (CEPs) to were recorded from all explored regions, except striate anterior cingulated, postcentral gyrus. Percentages...

The present study provides a functional mapping of vestibular responses in the human insular cortex.A total 642 electrical stimulations insula were performed 219 patients, using stereotactically implanted depth electrodes, during presurgical evaluation drug-refractory partial epilepsy. We retrospectively identified 41 contacts where stimulation elicited sensations (VSs) and analyzed their location with respect to (1) stereotactic coordinates (for all contacts), (2) anatomy gyri 20 sites),...

Objective: To test the influence of functional cerebral reorganization in amyotrophic lateral sclerosis (ALS) on disease progression.Methods: Nineteen predominantly right-handed ALS patients and 21 controls underwent clinical evaluation, Magnetic Resonance Imaging (fMRI), diffusion tensor imaging.Patients were clinically re-evaluated 1 year later followed until death.For fMRI, subjects executed imagined a simple hand-motor task.Between-group comparisons performed, correlations searched with...

Abstract Observing other people's pain increases our own reports to painful stimuli, a phenomenon that can be defined as ‘compassional hyperalgesia’ ( CH ). This functional magnetic resonance imaging study examined the neural correlates of , and whether could emerge when exposure driving stimulus was subliminal. Subjects received electric somatosensory stimuli while observing images people undergoing or enjoyable somatic sensations, presented during period allowing not conscious perception....

Abstract Background Brain areas involved in nociception have been repeatedly investigated. Therefore, brain responses to physiological pain conditions are well identified. The same is not true for allodynic patients with neuropathic since the cortical reorganizations that conversion of non‐noxious stimuli into painful sensations still remain unknown. Methods present positron emission tomography ( PET ) study enrolled 19 dynamic mechanical allodynia brushing or cold rubbing skin. activations...

Abstract We used functional magnetic resonance imaging to compare the human brain regions involved in orientation discrimination of two‐dimensional (2D) objects and gratings. The tasks, identification successive discrimination, were contrasted a dimming detection control condition with identical retinal input. Regions very similar for two types tasks stimuli both belonged dorsal ventral visual pathways. They included posterior occipital, lingual, fusiform, inferior temporal, intraparietal...

<h3>BACKGROUND AND PURPOSE:</h3> The functional characterization of the motor cortex is an important issue in presurgical evaluation brain lesions. fMRI noninvasively identifies areas while patients are asked to move different body parts. This task-based approach has some drawbacks clinical settings: long scanning times and exclusion with severe or neurologic disabilities children. Resting-state can avoid these difficulties because do not perform any goal-directed tasks. <h3>MATERIALS...

The physiological and behavioural effects of empathy for other's pain have been widely investigated, while the opposite situation, i.e. influence on one's empathetic feedback from others, remains largely unexplored. Here, we assessed whether how unempathetic comments observers modulate associated vegetative reactions. In Study 1, conversations between a study were recorded by professional actors. Comments prepared to be perceived as empathetic, or neutral, validated in 40 subjects....

Sleep-related breathing disorders (SRBDs) affect as many 40% of elderly people. The association SRBDs with structural brain abnormalities remains unclear. In this observational study, we evaluated gray matter changes in the associated sleep volunteers and their relationship severity SRBDs.One hundred fifty two healthy subjects aged 66.0 +/- 0.6 years-old underwent tridimensional MRI nocturnal polygraphic recording during which apnea/hypopnea index (AHI) oxyhemoglobin desaturation (ODI) were...

Healthy subjects remember emotional stimuli better than neutral, as well embedded in an context. This memory of messages is linked to amygdalo-hippocampal cooperation taking place a larger fronto-temporal network particularly sensitive pathological aging. Amygdala mainly involved gist messages. Whether content or context enhances mild Alzheimer's disease (AD) patients still debated. The aim the present study examine influence and on AD, whether this amygdala volume. Fifteen affected by AD 15...

Abstract Empathetic verbal feedback from others has been shown to alleviate the intensity of experimental pain. To investigate brain changes associated with this effect, we conducted 3T-fMRI measurements in 30 healthy subjects who received painful thermal stimuli on their left hand while overhearing empathetic, neutral or unempathetic comments, supposedly made by experimenters, via headsets. Only empathetic comments significantly reduced pain ratings. A whole-brain BOLD analysis revealed...

We report here the case of a female patient who developed following behavioural changes after brain lesion involving left posterior insula and SII cortices. She discovered de novo artistic capabilities for painting, with an episodic compulsive need to paint ("hyperpainting"), but also exhibited in her ability feel emotions. In addition, she had typical neuropathic pain syndrome, including provoked spontaneous pain, whose intensity was worsened when painted cold colours. This case-report...