A5011247051- Ocular Oncology and Treatments
- Renal and related cancers
- Thyroid and Parathyroid Surgery
- Renal cell carcinoma treatment
- Thyroid Cancer Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Congenital Diaphragmatic Hernia Studies
- Sarcoma Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Brain Metastases and Treatment
- Glioma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Pituitary Gland Disorders and Treatments
- Gastrointestinal disorders and treatments
- Dermatology and Skin Diseases
- Congenital heart defects research
- Glaucoma and retinal disorders
- Neuroendocrine Tumor Research Advances
- IgG4-Related and Inflammatory Diseases
- Urological Disorders and Treatments
- Intraocular Surgery and Lenses
- Cancer Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Ocular Infections and Treatments
- Acne and Rosacea Treatments and Effects
Ministry of Health of the Russian Federation
2020-2024
Russian Cancer Research Center NN Blokhin
2016-2017
Academy of Medical Sciences
2000
Genetically caused medullary thyroid cancer (MTC) is associated with unfavorable survival prognosis, so it makes necessary to develop new diagnostic techniques reveal pre-clinical stage of disease as well introduce into clinical practice the effective method tumor prevention. The article represents first in Russia summary experience prophylactic thyroidectomy have been executed period 1998 – 2015 yeas among ten bearers RET gene germlinemutation families hereditary including syndrome MEN2A...
Thyroid diseases in childhood occupy the second place after obesity structure of general pathology endocrine system, eating disorders and metabolic children Russian Federation. cancer makes up from 1.5 to 3 % all malignant tumors, 8 22 solid tumors head neck, younger child’s age, more aggressive disease proceeds. Familial forms thyroid may be associated with geographical features (living iodine-deficient regions), but also part hereditary syndromes, such as: multiple neoplasia syndromes...
Treatment intensification of acute lymphoblastic leukemia in children with L-asparaginase (L-ASP) improves therapy effectiveness and shows high survival rates. The unique biological properties this enzyme make it possible to suppress tumor blasts proliferation by reducing blood asparagine concentration. L-ASP use is limited toxicity hypersensitivity reactions observed 75 % cases. Although most complications during are mild/moderate manageable adequate accompanying therapy, the development...
L-asparaginase is one of the most effective drugs in pediatric and adult acute lymphoblastic leukemia treatment. But drug side effects are an important problem. pancreatitis pancreatic necrosis not common (2–18 %) complication, but high chance severe disease with fatal outcome make to bring careful attention oncologists-hematologists, surgeons, intensivists, radiologists. Recognizing multidisciplinary importance this problem, at June 21 st , 2023 Morozov Children’s Clinical hospital a Round...
Introduction. Retinoblastoma (Rb) is a rare intraocular tumor, which predominantly occurs in young children. The number of scientific studies and research, dedicated to extraocular Rb with extension on the optic nerve limited. There no uniform opinion how choose place method surgical phase treatment for patients tumor’s nerve. Description case report . article presents clinical patient at age 5years 1 month. After 3 courses polychemotherapy one-stage sequential operation was performed,...
Background . Undifferentiated embryonal sarcoma of the liver (UESL) is a rare malignant mes-enchymal tumor that occurs predominantly in children. Diagnosis delay often happens due to deficiency clinical symptoms, radiological findings, and serological markers. Objektive was describe imaging features undifferentiated Materials Six children with UESL (5 girls 1 boy) were observed treated at Research Center Pediatric Oncology between 2008 2016. The median age 6.5 years (from 4 months 11 years)....
Present study included 22 participants range in age from 1.5 to 16 years old with ultrasound features of an ectopic thymus thyroid gland. The lesion structure was typical for the each case. location and size normal. lesions gland had oval (89.7%) or irregular (10.3%) shape sharp (100%) (79.3%) regular (20.7%) contour, low echogenecity (100%), thin linear combination granular hyperechoic (31%) inclusions, avascularity (86.4%) hypovascularity (13.6%). In 5 larger than 10 mm diagnosis confirmed...
The detection of an intraocular embryonic tumor – retinoblastoma (RB) in children and its differential diagnosis with diseases mimicking RB is important task imaging. Considering that the clinical radiological patterns it may be similar, choice a treatment strategy carried out without preliminary histological examination, primary decisive importance. A comprehensive diagnostic approach for suspected provides timely optimal tactics improves prognosis. article presents most demonstrative own...
Present study included 22 participants range in age from 1.5 to 16 years old with ultrasound features of an ectopic thymus thyroid gland. The lesion structure was typical for the each case. location and size normal. lesions gland had oval (89.7%) or irregular (10.3%) shape sharp (100%) (79.3%) regular (20.7%) contour, low echogenecity (100%), thin linear combination granular hyperechoic (31%) inclusions, avascularity (86.4%) hypovascularity (13.6%). In 5 larger than 10 mm diagnosis confirmed...
Some nontumor processes can resemble renal tumors both clinically and morphologically. Malformations in the kidneys lead to that latter preserve primitive tissue elements be mistaken for nephroblastic tumors. In their clinical practice, pediatric oncologists most frequently come across, among tumor-like simulating nephroblastoma (NB), a massive blastema is also known as nephroblastomatosis (NBM). The paper demonstrates there no unified notion of NBM children need options treatment. It...
Tumor lesion of the orbit is found in clinic various oncohematological diseases children. Untimely referral such patients to an oncologist delays timing necessary treatment, thereby worsening prognosis disease. The literature review presents features clinical manifestations orbital pathology children at onset acute myeloid leukemia, sarcoma, lymphoma, Langerhans cell and non-Langerhans histiocytosis. article our own observations identifies factors that negatively affect timely diagnosis this...
Introduction. Regional blockades in children ophthalmology operations are used not only for analgesia the intra- and postoperative period, but also prevention of oculocardial reflex (OCR), nausea vomiting (PONV). But there is still no convincing data on advantages methods retrobulbar blockade (RBB) performed under ultrasound guidance parabulbar (PBB) guidance. Aim. In present study, we investigated efficacy safety RBB with ropivacaine 0.5 % OCR pain, as well PONV when detected PBB upon...
The aim of this work is to evaluate the informativity ultrasound (US) in detecting retinoblastoma (RB) and local invasion tumor children using modern multi-purpose scanners. Materials methods. This study included 108 patients (216 eyes) examined for suspected RB. RB was diagnosed 91 patients, 60 had unilateral tumor, 31 – bilateral (122 eyes). In remaining 17 (20 eyes damaged), different non-tumor pathology eye revealed. Among 122 affected by RB, 51 were removed with subsequent histological...
Introduction . Liver tumors account for 1.1 % of all newly diagnosed neoplasms in children. The rarity this pathology causes difficulties differential diagnosis. Currently, magnetic resonance imaging (MRI) is the main and most promising method diagnosing liver diseases. In our work, we decided to quantify data from study. Purpose study – determination possibilities quantitative assessment multiparametric MRI diagnosis benign malignant Material methods 133 patients with 307 lesions aged 5...
Ewing’s sarcoma (ES) of the kidney is an extremely rare malignant tumor characterized by aggressive course, and therefore disease has unfavorable prognosis. Due to occurrence, standards for treatment ES have not been developed; integrated approach often used in therapy. In this article, we present a description two clinical cases damage with patients aged 10 16 who were treated at Research Institute Pediatric Oncology Hematology named after Academician Russian Academy Medical Sciences L.A....
For the first time, a clinical observation of rare case mature teratoma kidney in child aged 5 months is presented domestic literature. A literature review given on this topic. The picture, characteristic signs tumor during ultrasound and X-ray computed tomography, results surgical procedure receive full coverage. Special attention paid to morphological characteristics teratoma.