A5018654342- Asthma and respiratory diseases
- Pediatric health and respiratory diseases
- Neonatal and fetal brain pathology
- Inflammatory mediators and NSAID effects
- Inflammation biomarkers and pathways
- Respiratory viral infections research
- Immune cells in cancer
- Advanced Glycation End Products research
- Immune Response and Inflammation
- Fibroblast Growth Factor Research
- Anesthesia and Neurotoxicity Research
- Neonatal and Maternal Infections
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer, Hypoxia, and Metabolism
- Metabolism and Genetic Disorders
- Neonatal Respiratory Health Research
- Pulmonary Hypertension Research and Treatments
- Bioinformatics and Genomic Networks
- Traumatic Brain Injury and Neurovascular Disturbances
- Galectins and Cancer Biology
- Renin-Angiotensin System Studies
- T-cell and B-cell Immunology
- Mast cells and histamine
- Educational Reforms and Innovations
- Computational Drug Discovery Methods
Third Affiliated Hospital of Zhengzhou University
2009-2022
Zhengzhou University
2004-2022
Liaocheng People's Hospital
2016-2017
University of Benin
2015
Yantaishan Hospital
2015
The mTOR pathway has been implicated in immune functions; however, its role asthma is not well understood. We found that patients experiencing an attack, when compared with remission, showed significantly elevated serum activation, increased Th17 cells and IL-4, decreased Treg IFN-γ. In asthma, activation was positively correlated the loss of Th17/Treg Th1/Th2 balance. further confirmed using ovalbumin-induced asthmatic mouse model. activated mice, demonstrated by levels p-PI3K, p-Akt,...
Exosomes, membranous nanovesicles, naturally bringing proteins, mRNAs, and microRNAs (miRNAs), play crucial roles in tumor pathogenesis. This study was to investigate the role of miR-155-3p from M2 macrophages-derived exosomes (M2-Exo) promoting medulloblastoma (MB) progression by mediating WD repeat domain 82 (WDR82).miR-155-3p expression detected RT-qPCR. The relationship with clinicopathological features MB patients analyzed. M2-Exo were isolated identified TEM, NTA Western blot. CCK-8...
Objective To investigate myeloid-derived suppressor cell (MDSC) accumulation and interleukin 10 (IL-10) 12 (IL-12) levels during the onset of asthma in both pediatric patients mouse models, as well their possible roles development asthma. Methods Peripheral blood samples were gathered from children with attacks (attack group) alleviated (alleviated group), two control groups, pneumonia healthy children. The pathological characteristics asthmatic mice, budesonide-treated normal mice also...
To evaluate the changes of rectus abdominis thickness and inter-rectus distance before after delivery with high-frequency ultrasound.A total 148 pregnant women at 12 weeks gestation who underwent prenatal examination in our hospital from January 2019 to March 2020 were selected, 140 them cooperated examination. According results 42 days delivery, 97 patients divided into DRA group isolated 43 normal not isolated. At weeks, 24 37 pregnancy, 3 spacing left right muscle measured by ultrasound...
Purpose: To investigate the effect of dimedone pyrone (DP) on podocytes in rats with diabetic nephropathy (DN).Methods: The were randomly assigned into 5 experimental groups (n = 10), viz, non-diabetic control no treatment (ND/NT), (DG/NT), treated mg/kg (DG/DP 5), 10 10) and 20 mg/kk 20) group. Clinical parameters, including 24 h urinary protein, blood urea nitrogen (BUN), serum creatinine (SCR), glucose (GLU), kidney weight (KW)/body (BW) determined after 12 weeks treatment. Hematoxylin...
Objective To discuss the frequency distribution of single nucleotide polymorphisms (SNP) four asthma-related gene loci in asthmatic children Henan,and to investigate its association with genetic susceptibility childhood asthma and some clinical phenotypes Methods Fluorogenic quantitative PCR sequencing technique were employed detect distributions SNP 135 98 healthy controls.Results The genotype DD angiotensin-converting enzyme (ACE)had a significantly higher than controls (x2 =26.475,P ＜...