A5054402021- Pediatric health and respiratory diseases
- Neonatal Respiratory Health Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Advanced Glycation End Products research
- Respiratory Support and Mechanisms
- Immune Response and Inflammation
- Lipid metabolism and disorders
- Inflammation biomarkers and pathways
- Congenital Diaphragmatic Hernia Studies
- Child Nutrition and Water Access
- Neonatal and Maternal Infections
- Inflammatory mediators and NSAID effects
- Angiogenesis and VEGF in Cancer
- Clinical Nutrition and Gastroenterology
- Infant Nutrition and Health
- Mast cells and histamine
- Streptococcal Infections and Treatments
- Proteoglycans and glycosaminoglycans research
- Respiratory viral infections research
- Infant Health and Development
- PI3K/AKT/mTOR signaling in cancer
- Fatty Acid Research and Health
- Nutrition and Health in Aging
- Respiratory and Cough-Related Research
Third Affiliated Hospital of Zhengzhou University
2008-2023
The mTOR pathway has been implicated in immune functions; however, its role asthma is not well understood. We found that patients experiencing an attack, when compared with remission, showed significantly elevated serum activation, increased Th17 cells and IL-4, decreased Treg IFN-γ. In asthma, activation was positively correlated the loss of Th17/Treg Th1/Th2 balance. further confirmed using ovalbumin-induced asthmatic mouse model. activated mice, demonstrated by levels p-PI3K, p-Akt,...
Objective To investigate myeloid-derived suppressor cell (MDSC) accumulation and interleukin 10 (IL-10) 12 (IL-12) levels during the onset of asthma in both pediatric patients mouse models, as well their possible roles development asthma. Methods Peripheral blood samples were gathered from children with attacks (attack group) alleviated (alleviated group), two control groups, pneumonia healthy children. The pathological characteristics asthmatic mice, budesonide-treated normal mice also...
To investigate the role of high mobility group box 1 (HMGB1) and receptor for advanced glycation end product (RAGE) in lungs hyperoxia-induced rats effect N--acetlycystein (NAC).A model hyperoxic lung injury was established, NAC intervention, control, hyperoxia were given nebulized aerosol, same volume saline once a day 7 consecutive days, respectively. Wet/dry ( W/ D) ratio determined to evaluate edema tissues. Conventional hematoxylin-eosin (HE) staining used observe pathological changes...
Objective To observe the incidence of malnutrition and nutritional risk in children with pneumonia on mechanical ventilation pediatric intensive care unit (PICU), to explore support effect short-peptide enteral nutrition formula. Methods A total 68 severe who were hospitalized PICU from October 2017 2018 required enrolled for a prospective randomized controlled study. The randomly divided into control group an experimental group. Through nasogastric feeding tube, received formula,...
Objective To investigate the changes in tidal breathing lung function of severe pneumonia recovery phase and correlation with condition prognosis infants young children. Methods Tidal 44 cases 50 mild their were measured by infantile spirometer made Germany.According to ratio exhaled volume at peak expi-ratory flow total expiratory volume(VPTEF/VE), divided into normal, mild, moderate groups.All these children followed up for frequency rehospitalization because lower respiratory tract...
Pulmonary function testing is essential for early detection, evaluation of severity and prognosis respiratory diseases, drugs other therapy effects, identification pathological changes breathing difficulties, assessment in surgery tolerance, etc.With the development children lung study various infectious non-infectious test will be gradually widely used pediatric clinical research practice.This review summarizes methods applications at home abroad. Key words: Children; Pulmonary...
Objective To study pathogen aetiology and distribution of drug resistance in neonatal septice-mia. Methods A retrospective positive organisms blood cultures the results antimicrobial suscep-tibility testing was conducted from January 2000 to December 2006 1293 cases septicemia;The were divided into three groups:the earlier group,the middle group later group. The strains identified by VITEK-AMS antibiotics susceptibility tested K-B method, interpreted according NCCLS. inant groups(76.3%...
Objective To explore the expression and significance of matrix metalloproteinases-9(MMP-9) tissue inhibitors metalloproteinase-1(TIMP-1) in serum at acute phase severe pneumonia infants. Methods A total 45 infants were selected divided into 20 cases group 25 mild according to severity disease, all also virus 24 non-virus 21 on basis etiology.Additionally, healthy children who accepted physical examination same time as control group.Serum levels MMP-9 TIMP-1 detected by using...
Objective To investigate the distribution and drug resistance of bacteria infection in children with pneumonia between pediatric intensive care ward respiratory , order to guide clinical treatment. Methods From 2010 January 2014 January, two-hundred sixty cases hospitalized were included severe group, 300 patients from into common group divided mechanical ventilation group(126 cases), non ventilation(134 invasive group(94 noninvasive group(32 cases). Conventional sputum specimens...
Objective To investigate the risk factors of severe community acquired pneumonia (CAP) in children. Methods One hundred and sixty cases CAP children were selected as case group, 160 non control group during same period. The clinical related with analyzed by univariate test Logistic multivariate regression analysis order to children. Results Univariate showed that age, residence, congenital heart disease, history recurrent infection, surgery, immunodeficiency, indoor environment,...