A5039885239- Colorectal Cancer Screening and Detection
- T-cell and B-cell Immunology
- Autophagy in Disease and Therapy
- Genetic factors in colorectal cancer
- Cannabis and Cannabinoid Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Gut microbiota and health
- Immune cells in cancer
- Calcium signaling and nucleotide metabolism
University of North Dakota
2022-2024
Colon cancer affects people of all ages. However, its frequency, as well the related morbidity and mortality, are high among older adults. The complex physiological changes in aging gut substantially limit development therapies. Here, we identify a unique intestinal microenvironment that is linked with an increased risk colon Our findings show markedly influences persistent fucosylation apical surfaces epithelial cells, which results favorable environment for tumor growth. Furthermore, our...
In this commentary, we highlight autophagy's important function, while identifying potential therapeutic targets for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the elderly. Autophagy's decline elderly causes increased cell senescence and a dysregulated immune system. As demographic often faces decreased vaccine-provided immunity, disease 2019 treatments must be developed. We discuss recent study by Acharya et al. (2022) that found SF2523 induced autophagy, reducing...
Abstract A decline in mitochondrial activity has been linked to T cell dysfunction and the progression of a variety diseases. It is unclear whether function regulatory cells (Tregs) determines effector fate decisions regulates steady-state inflammation. We show that loss Mitochondrial Transcription Factor Foxp3 + Tregs (TFAM cKO) affects cellular transcriptional dynamics CD4 cells, resulting disproportional heterogeneity prevalence pathogenic subsets. Failure modulate responses results...