A5104706685- Neurobiology and Insect Physiology Research
- Insect and Arachnid Ecology and Behavior
- Physiological and biochemical adaptations
- Neurogenesis and neuroplasticity mechanisms
- Spinal Cord Injury Research
- Nerve injury and regeneration
- Pharmacological Effects of Natural Compounds
- Traumatic Brain Injury and Neurovascular Disturbances
- Insect Utilization and Effects
- Insect symbiosis and bacterial influences
- Robotic Locomotion and Control
- Pain Mechanisms and Treatments
- Spine and Intervertebral Disc Pathology
- Acute Ischemic Stroke Management
- Neurogenetic and Muscular Disorders Research
- Hemoglobin structure and function
- Protease and Inhibitor Mechanisms
- Wound Healing and Treatments
- Adhesion, Friction, and Surface Interactions
- Stress Responses and Cortisol
- Antioxidant Activity and Oxidative Stress
- Vector-borne infectious diseases
- Circadian rhythm and melatonin
- Spinal Dysraphism and Malformations
- Periodontal Regeneration and Treatments
University of Lausanne
2015-2019
University of Louisville
2006-2011
University of Oklahoma Health Sciences Center
1995-2011
Neurological Surgery
2006
Abstract Ticks transmit more pathogens to humans and animals than any other arthropod. We describe the 2.1 Gbp nuclear genome of tick, Ixodes scapularis (Say), which vectors that cause Lyme disease, human granulocytic anaplasmosis, babesiosis diseases. The large reflects accumulation repetitive DNA, new lineages retro-transposons, gene architecture patterns resembling ancient metazoans rather pancrustaceans. Annotation scaffolds representing ∼57% genome, reveals 20,486 protein-coding genes...
Ionotropic Receptors (IRs) are a large subfamily of variant ionotropic glutamate receptors present across Protostomia. While these most extensively studied for their roles in chemosensory detection, recent work has implicated two family members, IR21a and IR25a, thermosensation Drosophila. Here we characterize one the evolutionarily deeply conserved receptors, IR93a, show that it is co-expressed functions with IR25a to mediate physiological behavioral responses cool temperatures. IR93a also...
Animals rely on highly sensitive thermoreceptors to seek out optimal temperatures, but the molecular mechanisms of thermosensing are not well understood. The Dorsal Organ Cool Cells (DOCCs) Drosophila larva a set exceptionally thermosensitive neurons critical for larval cool avoidance. Here, we show that DOCC cool-sensing is mediated by Ionotropic Receptors (IRs), family sensory receptors widely studied in invertebrate chemical sensing. We find two IRs, IR21a and IR25a, required mediate...
To escape danger or catch prey, running vertebrates rely on dynamic gaits with minimal ground contact. By contrast, most insects use a tripod gait that maintains at least three legs the any given time. One prevailing hypothesis for this difference in fast locomotor strategies is locomotion allows to rapidly navigate three-dimensional terrain. test this, we computationally discovered model based Drosophila melanogaster. Indeed, emerges exclusion of many other possible when optimizing upward...
Abstract The development of remyelinating strategies designed to enhance recruitment and differentiation endogenous precursor cells available a site demyelination in the adult spinal cord will require fundamental understanding potential for remyelinate as well an insight into epigenetic cues that regulate their mobilization differentiation. ability embryonic postnatal neural cell transplants central nervous system is documented, while no transplantation studies date have examined...
Abstract Functional impairment after spinal cord injury (SCI) is partially attributed to neuronal cell death, with further degeneration caused by the accompanying apoptosis of myelin‐forming oligodendrocytes. The Eph receptor protein tyrosine kinase family and its cognate ligands, ephrins, have been identified be involved in axonal outgrowth, synapse formation, target recognition, mainly mediated repulsive activity. Recent reports suggest that ephrin/Eph signaling might also play a role as...
Following inflammation, primary sensory neurons in the dorsal root ganglion (DRG) alter production of several proteins. Most DRG are glutamatergic, using glutaminase as enzyme for glutamate production, but little is known about following inflammation. In present study, adjuvant-induced arthritis (AIA) was produced rats with complete Freund's adjuvant into hindpaw. At 7 days AIA, were examined immunohistochemistry, Western blot immunoreactivity, and activity. Image analysis revealed that...
Abstract Ionotropic Receptors (IRs) are a large subfamily of variant ionotropic glutamate receptors present across Protostomia. While these most extensively studied for their roles in chemosensory detection insects, recent work has implicated two family members, IR21a and IR25a, thermosensation Drosophila . Here we characterize one the deeply conserved receptors, IR93a, show that it is co-expressed functions with IR25a to mediate physiological behavioral responses cool temperatures. IR93a...
Abstract Animals rely on highly sensitive thermoreceptors to seek out optimal temperatures, but the molecular mechanisms of thermosensing are not well understood. The Dorsal Organ Cool Cells (DOCCs) Drosophila larva a set exceptionally thermosensitive neurons critical for larval cool avoidance. Here we show that DOCC cool-sensing is mediated by Ionotropic Receptors (IRs), family sensory receptors widely studied in invertebrate chemical sensing. We find two IRs, IR21a and IR25a, required...