A5028137026- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipid metabolism and disorders
- Vitamin C and Antioxidants Research
- Biochemical Analysis and Sensing Techniques
- Vitamin D Research Studies
- Nutrition, Genetics, and Disease
- Cancer-related molecular mechanisms research
- Adipokines, Inflammation, and Metabolic Diseases
- Regulation of Appetite and Obesity
Dasman Diabetes Institute
2014-2016
Abstract Betatrophin/ANGPTL8 is a newly identified hormone produced in liver and adipose tissue that has been shown to be induced as result of insulin resistance regulates lipid metabolism. Little known about betatrophin level humans its association with T2D metabolic risk factors. Plasma was measured by ELISA 1603 subjects: 1047 non-diabetic 556 subjects associations factors both were also studied. Our data show significant difference levels between (731.3 (59.5–10625.0) pg/ml) (1710.5...
Background A number of genetic studies have reported an association between vitamin D related genes such as group-specific component gene (GC), Cytochrome P450, family 2, subfamily R, polypeptide 1 (CYP2R1) and 7-dehydrocholesterol reductase/nicotinamide-adenine dinucleotide synthetase (DHCR7/NADSYN1) serum levels the active form Vitamin D, 25 (OH) among African Americans, Caucasians, Chinese. Little is known about how variations associate with, or contribute to, 25(OH)D in Arabs...
ANGPTL8 also called betatrophin is a regulator of lipid metabolism through its interaction with ANGPTL3. It has been suggested to play role in insulin resistance and beta-cell proliferation. Based on function, we hypothesized that will Metabolic Syndrome (MetS). To test this hypothesis designed study measure level subjects MetS as well association high sensitivity C-reactive protein (HsCRP) humans. was measured using ELISA their controls, total 1735 were enrolled. HsCRP examined. higher...
Betatrophin has been suggested as an inducer of β-cell proliferation in mice addition to its function regulating triglyceride. Recent data showed that betatrophin was increased Type 2 Diabetes (T2D), however, ability induce insulin production questioned. We hypothesized the T2D is not affecting from β-cells. To test this hypothesis, we investigated association between and C-peptide level humans, which acts a measure endogenous β-cells.This study designed examine plasma 749...
Ghrelin is a stomach produced hormone that has been shown to have protective role against development of CVD which leading cause death in the Arab world. The objective this study examine gender difference association between traditional risk factors and plasma ghrelin among Arabs. 359 residents Kuwait participated cross-sectional survey (≥20 years old): 191 were females 168 males. Plasma level was assessed using Luminex-based assay. levels significantly higher (935 ± 78 pg/mL) than males...