A5089617727- Ultrasound and Hyperthermia Applications
- 3D Printing in Biomedical Research
- Thermal Regulation in Medicine
- Head and Neck Cancer Studies
- Cervical Cancer and HPV Research
- Cancer Research and Treatments
- Virus-based gene therapy research
- Cancer, Hypoxia, and Metabolism
- Infrared Thermography in Medicine
- Cleft Lip and Palate Research
- Legionella and Acanthamoeba research
- Effects of Radiation Exposure
- Nanoplatforms for cancer theranostics
- Innovative Microfluidic and Catalytic Techniques Innovation
- Vibrio bacteria research studies
- Vector-borne infectious diseases
- Veterinary Oncology Research
- Cancer-related molecular mechanisms research
University of Antwerp
2021-2024
Antwerp University Hospital
2024
Rode Kruis-Vlaanderen
2021
Texas A&M Health Science Center
2010
Coxiella burnetii is an obligate intracellular bacterial pathogen responsible for acute and chronic Q fever. This bacterium harbors a type IV secretion system (T4SS) highly similar to the Dot/Icm of Legionella pneumophila that believed be essential its infectivity. Protein substrates T4SS are predicted facilitate biogenesis phagosome permissive growth. However, due lack genetic systems, protein transfer by C. has not been demonstrated. In this study, we report identification 32 using...
Abstract Background The incidence of high-risk human papillomavirus (hrHPV)-driven head and neck squamous cell carcinoma, in particular oropharyngeal cancers (OPC), is increasing high-resource countries. Patients with HPV-induced cancer respond better to treatment consequently have lower case-fatality rates than patients HPV-unrelated OPC. These considerations highlight the importance reliable accurate markers diagnose truly Methods accuracy three possible test strategies, i.e. (a) hrHPV DNA...
Objective: Thermal treatment (TT), defined as using supra-physiological body temperatures (39–45 C), somewhat resembles fever in terms of temperature range, one the first natural barriers for to fight exposure external pathogens.Methods: Whole-body thermal (WBTT) consists heating up complete a range 39 45 C. Despite recognized therapeutic potential hyperthermia, broad clinical use WBTT has been limited by safety issues related medical devices and procedures used achieve WBTT, particular...
Aim: In oncology, thermal therapy is the application of external heat to fight cancer cells. The goal whole-body treatment (WBTT) raise patient's core temperature 39-42 °C, and represents only modality that can act on both primary tumor distant metastases. However, WBTT carries potential risks for toxicity when applied without accurate thermometry monitoring.Methods: ElmediX has developed a medical device, HyperTherm, deliver long-term controlled (41.5 up 8 h). safety device protocol was...
Abstract BACKGROUNDThe incidence of high-risk human papillomavirus (hrHPV)-driven head and neck squamous cell carcinoma, in particular oropharyngeal cancers (OPC), is increasing high-resource countries. Patients with HPV-induced cancer respond better to treatment consequently have lower case-fatality rates than patients HPV-unrelated OPC. These considerations highlight the importance reliable accurate markers diagnose truly METHODSThe accuracy three possible test strategies, i.e. a) hrHPV...
TPS625 Background: Whole-Body Hyperthermia (WBHT) represents the only hyperthermia modality available for patients with disseminated malignancies. The rationale treatment of malignant disease by heat is based on a direct cell-killing effect at temperatures in range 41– 42°C and driven number reasons. Phase-I mining phase-I veterinary (dog) clinical study proved safety WBHT alone combination standard care therapy dogs cancer. A systematic review addressed trials that used pancreatic cancer...
An in silico model of a theoretical local hyperthermia device was created COMSOL®. In this the is placed around pancreas with aim treating pancreatic cancer. The would be through surgical access. It then used as means to treat cancer mild hyperthermia, conjunction standard care treatment. paper steps building COMSOL® are discussed. These include geometry, allocation material properties, implementation physics modules, meshing geometry and, finally, setup studies order run simulations. This...
Abstract Hyperthermia, the procedure of raising temperature a part entire body above normal for defined period time, is applied alone or as an adjunctive treatment to various established cancer modalities such radiotherapy and chemotherapy. Whole-Body Hyperthermia (WBHT), in contrast local regional hyperthermia, represents only hyperthermia modality available patients with disseminated malignancies. The biological rationale malignant disease by heat driven number reasons; a) survival cells...
Abstract In recent years, hyperthermia (HT) is gaining popularity as a therapeutic modality that could potentiate other treatments such chemotherapy. Although pre-clinical and clinical research do suggest beneficial effect of moderate HT (41.5°C), more knowledge on the molecular mechanisms required before it can be routinely implemented in clinic. brief, several commercially available PDAC cell lines were subjected exposed to increasing durations at 41.5°C, ranging from for 6, 12, 24 hours....