A5013992714- Diabetes Treatment and Management
- Pharmacovigilance and Adverse Drug Reactions
- Diabetes Management and Research
- Diet and metabolism studies
- Hepatitis C virus research
- Hip disorders and treatments
- Bone and Joint Diseases
- Gastroesophageal reflux and treatments
- Systemic Lupus Erythematosus Research
- Multiple Myeloma Research and Treatments
- Medical Device Sterilization and Disinfection
- Pathogenesis and Treatment of Hiccups
- Viral gastroenteritis research and epidemiology
- Thyroid Cancer Diagnosis and Treatment
- Pharmacy and Medical Practices
- Medication Adherence and Compliance
- Thyroid and Parathyroid Surgery
- Colorectal Cancer Treatments and Studies
- Gastrointestinal motility and disorders
- HIV/AIDS drug development and treatment
- Pediatric Pain Management Techniques
- Pharmaceutical Practices and Patient Outcomes
- vaccines and immunoinformatics approaches
- Hepatitis B Virus Studies
- Pharmaceutical studies and practices
Takeda (Japan)
2007-2024
Osaka City University Hospital
2013
Osaka City University
2010
Marymount University
2009
The systemic use of steroids and habitual alcohol intake are two major causative factors in the development idiopathic osteonecrosis femoral head (ONFH). To examine any interaction between oral corticosteroid on risk ONFH, we conducted a hospital-based case-control study 71 cases with ONFH (mean age 45 years (20 to 79)) 227 matched controls 47 (18 79)). Alcohol was positively associated among all subjects: adjusted odds ratio (OR) subjects ≥ 3032 drink-years 3.93 (95% confidence interval...
Abstract Purpose To estimate the incidence of lactic acidosis (LA) and role metformin in Japanese patients with type 2 diabetes mellitus (T2DM) treated anti‐diabetes drugs. Methods This retrospective propensity score matched cohort study was conducted using Medical Data Vision claims database. T2DM aged 18 or above who received drugs during January 2010 through August 2014 were identified. Cases LA identified based on reimbursement codes confirmed by acid test subsequent treatment...
After the launch of dipeptidyl peptidase-4 (DPP-4), a new oral hypoglycemic drug (OHD), in December 2009, severe hypoglycemia cases were reported Japan. Although definite cause was unknown, co-administration with sulfonylureas (SU) suspected as one potential risk factors. The Japan Association for Diabetes Education and Care (JADEC) released recommendation April 2010 to lower dose three major SUs (glimepiride, glibenclamide, gliclazide) when adding DPP-4 inhibitor. To evaluate effectiveness...
Cyclic vomiting syndrome (CVS) is a gastrointestinal disorder that characterized by recurrent episodes of vomiting. Previous studies have provided reliable data on the prevalence CVS among children in Japan; however, neither nor incidence available for adults. Hence, we obtained detailed and estimated total number cases Japan. This retrospective cross-sectional study was conducted using JMDC (JMDC, Inc.; formerly known as Japan Medical Data Center Co., Ltd.,) database, which de-identified...
Background The burden of medically-attended acute gastro-enteritis (MA-AGE) that can be attributed to norovirus is not well established in Japan. Using a nationwide database medical care insurance claims, we estimated the incidence norovirus-attributable gastroenteritis (MA-NGE) Methods incidences MA-NGE outpatient consultations or hospitalization Japan were modelled on seasonal patterns MA-AGE for unspecified causes derived from Medical Data Center (JMDC) period July 2007 June 2015. Results...
Ixazomib citrate (IXA) in combination with lenalidomide and dexamethasone (IRD therapy) has been approved for the treatment of relapsed or refractory multiple myeloma. In Japan, as these three drugs have different dosing schedules, instructions patients prepared distributed to via healthcare professionals promote an understanding appropriate regimen, additional risk minimization measure (aRMM).
Hypoparathyroidism is a rare endocrine disorder characterized by low serum calcium and elevated phosphorus levels. Patients who do not recover parathyroid function after surgeries or have nonsurgical causes involving congenital metabolic diseases, require long-term use of active vitamin D supplementation as conventional therapy in Japan. This study aimed to estimate prevalence chronic hypoparathyroidism investigate its disease etiology, patient characteristics, treatment Japan, using health...
2012年4月，医薬品のリスクを開発段階から製造販売後まで適正に管理するため，厚生労働省から医薬品リスク管理計画指針が発出された．本指針では，ICH の E2E ガイドラインに準拠して安全性検討事項，安全性監視計画を設定し，リスク最小化策を策定することが要求されている．しかし，2014年8月時点で公開されている医薬品リスク管理計画（RMP）の中には，リスクの大きさ，重大性，特性にかかわらず，従来の使用成績調査，特定使用成績調査を安全性検討事項共通の安全性監視活動として計画している事例も存在していると考えられる．...
教室で経験したCrohn病13例の外科的治療および遠隔成績について検討した.性別では,男10例,女3例と,男性が優位であった.初発時年齢は平均21.0歳であり,診断時の年齢は平均26.6歳と,5年のずれがあった.肛門病変が62%に合併しており,その半数が初発症状であったこと,虫垂切除の既往が39%に認められたことが,早期診断のために重要であると思われた。病変部位は,小腸型2例,小腸・大腸型8例,大腸型3例であり,手術は9例69%に施行した.手術適応は,瘻孔の合併が7例と,大多数を占めていた.手術の術式は,すべてに病変部位を含めた腸切除を行った.術後再発は6例に認められ,67%という高い再発率を示した.そのうち3例に再手術を行った.このことは,Crohn病に対する外科的治療の困難さを示している.